Abstract: Disclosed are compounds of Formula (I): or a pharmaceutically acceptable salt, a tautomer, a stereoisomer, or a deuterated analog thereof, wherein R1, R2, R3, R4, L and X are as described in any of the embodiments described in this disclosure; compositions thereof, and uses thereof.

Abstract: The present disclosure provides systems and methods that provide feedback to a user of an image capture device that includes an artificial intelligence system that analyzes incoming image frames to, for example, determine whether to automatically capture and store the incoming frames. An example system can also, in the viewfinder portion of a user interface presented on a display, a graphical intelligence feedback indicator in association with a live video stream. The graphical intelligence feedback indicator can graphically indicate, for each of a plurality of image frames as such image frame is presented within the viewfinder portion of the user interface, a respective measure of one or more attributes of the respective scene depicted by the image frame output by the artificial intelligence system.

Abstract: Techniques are disclosed relating to monitoring network traffic of an embeddable browser displayed by an application executing on a mobile computing device. In some embodiments, a first layer of the application manipulates one or more user interface elements displayed in the embeddable browser. The first layer of the application then detects network requests made by one or more application programming interfaces (APIs) executed by the embeddable browser in response to the manipulating. In some embodiments, the first layer sends to a second layer of the application results of observing network requests. In some embodiments, the second layer of the application displays, in real-time, information corresponding to the results of observing network requests.

Abstract: The present disclosure provides tissue-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in targeted tissues.

Abstract: The disclosed computer-implemented method may include systems for generating personalized avatar reactions during live video broadcasts. For example, the systems and methods described herein can access a social networking system user's profile to identify an avatar associated with the social networking system user. The systems and methods can generate an avatar reaction by modifying one or more features of the avatar based on a corresponding emoticon reaction. Once generated, the social networking system user can select the avatar reaction for addition to an ephemeral reaction stream associated with a live video broadcast. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A drain assembly includes a drain body, barrel, plug, and gasket. The drain body has an interior surface defining a channel along an axis and having interior threads thereon. The barrel has a central body having an upper end, with a flange extending radially outward therefrom and defining a landing surface. The central body has opposed exterior and interior barrel surfaces having exterior and interior threads, respectively. The interior barrel surface defines a channel alignable with the axis. The exterior threads are engageable with the drain body interior threads for axially adjusting the barrel relative to the drain body. The plug has a top wall and an outer body extending axially downward therefrom to a stop surface. A portion of the outer body extends axially below the stop surface and has external threads engageable with the barrel interior threads. The gasket is sealingly receivable between the stop and landing surfaces.

Abstract: A liquid desiccant regenerator configured to produce a first output stream with a higher concentration of a liquid desiccant than a first input stream. The regenerator also produces a second output stream with a lower concentration of the liquid desiccant than a second input stream. Regeneration of the liquid desiccant in the liquid desiccant regenerator decreases a temperature of the liquid desiccant regenerator. The system includes an air contactor coupled to the first output stream and exposing an input air stream to the first output stream. The first output stream absorbs water from the input air stream to form at least one diluted output desiccant stream. A heat pump of the system is thermally coupled to move the heat from the first output stream to the liquid desiccant regenerator. The heat moved to the liquid desiccant regenerator increases an efficiency of the liquid desiccant regenerator.

Abstract: In accordance with one or more embodiments herein, an integrated process for upgrading a hydrocarbon oil feed stream utilizing a delayed coker, steam enhanced catalytic cracker, and an aromatics complex includes solvent deasphalting the hydrocarbon oil stream; delayed coking the heavy residual hydrocarbons; hydrotreating the delayed coker product stream and the deasphalted oil stream to form a light C5+ hydrocarbon stream and a heavy C5+ hydrocarbon stream; steam enhanced catalytically cracking the light C5+ hydrocarbon stream; steam enhanced catalytically cracking the heavy C5+ hydrocarbon stream; passing at least a portion of the light steam enhanced catalytically cracked stream, the heavy steam enhanced catalytically cracked stream, or both to a product separator to produce a olefin product stream, a naphtha product stream, and a BTX product stream; and processing the naphtha product stream in the aromatics complex to produce benzene and xylenes.

Abstract: This disclosure describes, in part, systems for enabling facilities to implement techniques to determine when users are in possession of items when located within and/or exiting the facilities. For instance, a system may use one or more sensors to determine locations of a user that navigated through a facility. Additionally, the system may use one or more sensors to determine locations of an item while the item was located within the facility. The system may then determine a probability that the user was in possession of the item when in the facility and/or when exiting the facility based at least in part on the locations of the user and the locations of the item. If the system determines that the user was in possession of the item when exiting the facility, the system may charge a payment instrument of the user for a price of the item.

Abstract: Catalyst systems are provided, along with corresponding methods, for single stage conversion of synthesis gas to fuel boiling range products with increased selectivity for either naphtha production (C5-C9) or distillate production (C10-C20). The increased selectivity for naphtha production or distillate production is provided in conjunction with a reduced selectivity for higher boiling range components (C21+).

Abstract: Embodiments disclosed are directed to an immutable database in a data processing system for tracking a data state of the data processing system using multiple timelines or temporal sequences representing events occurring in the data processing system. The immutable database may maintain a current temporal sequence representing an existing data state of the data processing system and generate alternate temporal sequences representing an alternate data state of the data processing system. The alternate temporal sequence may be used to test retroactive events that are intended to replace or correct events that occurred in the current temporal sequence.

Abstract: The present disclosure relates to extracellular vesicles (EVs), e.g., exosomes, which can be rapidly modified to comprise an antigen of interest, and the uses of such EVs as vaccines for the treatment of wide range of diseases or disorders. Also provided herein are methods for preparing and manufacturing such EVs for use as vaccines.

Abstract: A battery electrode includes a first metal foil, a second metal foil, and a thermoplastic polymer layer between the first metal foil and the second metal foil. The battery electrode also includes a first coating adjacent to the first metal foil such that the first metal foil is between the thermoplastic polymer layer and the first coating. The battery electrode also includes a second coating adjacent to the second metal foil such that the second metal foil is between the thermoplastic polymer layer and the second coating.

Abstract: A method for data-driven professional network expansion techniques is implemented via a computing system including a processor. The method includes executing, via a network, an enterprise application on a remote computing system operated by a user associated with an enterprise and surfacing a professional networking UI on a display of the remote computing system during execution of the enterprise application. The method includes accessing enterprise-level data corresponding to the user and the enterprise, extracting parameters associated with the user and the enterprise from the enterprise-level data, and automatically generating, based on the extracted parameters, the user's professional network and a list of suggested professional contacts.

Abstract: Embodiments disclosed are directed to an immutable database with a bitemporal ledger for storing transactions in timelines for maintaining a record of all events and resources within the system. The bitemporal ledger may store a sequence of transactions which include a plurality of transactions previously received by the data processing system in a temporal sequence up to a current time. A new transaction is received and may be appended to the sequence of transactions based on temporal metadata associated with the transaction are received, The temporal metadata may include a valid-from time and a created-at time.

Abstract: A request may be received to transform records in a data lake that match one or more query criteria. Data lake records that match the criteria may be retrieved. The retrieved records may include two data lake records associated with the same data lake record identifier. A transformed record may be generated based on time stamps associated with the retrieved records.

Abstract: A cargo loading/unloading device for an aircraft includes a base, two arms pivotally movable on top of the base and a push rod pivotally connected to the base and sandwiched between the two arms. A cable extends through the push rod and forms into a loop after passing through a bottom end of the push rod so that a package is able to be securely transported with the cooperation of the push rod and the two arms and be released onto the arms when the package weight is not functioning.

Abstract: Embodiments disclosed are directed to implementing an immutable database. Several embodiments are directed to an architecture for implementing the immutable database as a data processing system with a real-time interface for buffering a plurality of transactions and a bitemporal ledger for storing the plurality of transactions and a processor. New transactions may be appended to the transaction to the plurality of transactions and processed in a temporal order which includes identifying a sequence of transactions in the bitemporal ledger associated with the transaction and incorporating the transaction into the sequence of transactions in the bitemporal ledger according to temporal metadata associated with the transaction to form an updated sequence of transactions.

Abstract: Embodiments disclosed are directed to an immutable database in a data processing system for tracking a data state of the data processing system using multiple timelines or temporal sequences representing events occurring in the data processing system. The immutable database may maintain a current temporal sequence representing an existing data state of the data processing system and generate alternate temporal sequences representing an alternate data state of the data processing system. The alternate temporal sequence may be used to test retroactive events that are intended to replace or correct events that occurred in the current temporal sequence.

Abstract: Embodiments disclosed are directed to an immutable database with a bitemporal ledger for storing transactions in timelines for maintaining a record of all events and resources within the system. The bitemporal ledger may store a sequence of transactions which include a plurality of transactions previously received by the data processing system in a temporal sequence up to a current time. A new transaction is received and may be appended to the sequence of transactions based on temporal metadata associated with the transaction are received, The temporal metadata may include a valid-from time and a created-at time.