Patents by Inventor Aarthi Chandrasekaran
Aarthi Chandrasekaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10131903Abstract: This invention provides methods and compositions for assembling biological constructs (e.g., plasmids, transformed cells, etc.). In certain embodiments the methods involve encapsulating separate components of the biological construct each in a fluid droplet confined in a fluid channel; optionally mixing droplets from different fluid channels to form a sequenced order of droplets carrying different components of the biological construct in a channel or chamber; and optionally combining two or more droplets each containing different components of the biological construct to permit the components to react with each other in one or more reactions contributing to the assembly of the biological construct.Type: GrantFiled: April 2, 2012Date of Patent: November 20, 2018Assignees: The Regents of the University of California, Sandia CorporationInventors: Chieh Chang, Rajiv Bharadwaj, Anup K. Singh, Aarthi Chandrasekaran, Nathan J. Hillson
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Publication number: 20180009850Abstract: The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.Type: ApplicationFiled: July 13, 2017Publication date: January 11, 2018Inventors: Rahul Raman, Xiaoying Koh, Karthik Viswanathan, Ram Sasisekharan, Aarthi Chandrasekaran
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Patent number: 9745352Abstract: The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.Type: GrantFiled: July 25, 2014Date of Patent: August 29, 2017Assignee: Massachusetts Institute of TechnologyInventors: Rahul Raman, Xiaoying Koh, Karthik Viswanathan, Ram Sasisekharan, Aarthi Chandrasekaran
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Publication number: 20150147329Abstract: The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.Type: ApplicationFiled: July 25, 2014Publication date: May 28, 2015Inventors: Rahul Raman, Xiaoying Koh, Karthik Viswanathan, Ram Sasisekharan, Aarthi Chandrasekaran
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Patent number: 8815522Abstract: The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.Type: GrantFiled: January 2, 2009Date of Patent: August 26, 2014Assignee: Massachusetts Institute of TechnologyInventors: Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan
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Patent number: 8802110Abstract: The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.Type: GrantFiled: September 21, 2011Date of Patent: August 12, 2014Assignee: Massachusetts Institute of TechnologyInventors: Rahul Raman, Xiaoying Koh, Karthik Viswanathan, Ram Sasisekharan, Aarthi Chandrasekaran
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Patent number: 8529889Abstract: The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.Type: GrantFiled: June 29, 2005Date of Patent: September 10, 2013Assignee: Massachusetts Institute of TechnologyInventors: Aarthi Chandrasekaran, Shiladitya Sengupta, David A. Berry, Kristine Holley, Ganlin Zhao, Ram Sasisekharan
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Publication number: 20120258487Abstract: This invention provides methods and compositions for assembling biological constructs (e.g., plasmids, transformed cells, etc.). In certain embodiments the methods involve encapsulating separate components of said biological construct each in a fluid droplet confined in a fluid channel; optionally mixing droplets from different fluid channels to for a sequenced order of droplets carrying different components of said biological construct in a channel or chamber; and optionally combining two or more droplets each containing different components of said biological construct to permit said components to react with each other in one or more reactions contributing to the assembly of said biological construct.Type: ApplicationFiled: April 2, 2012Publication date: October 11, 2012Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SANDIA CORPORATIONInventors: Chieh Chang, Rajiv Bharadwaj, Anup K. Singh, Aarthi Chandrasekaran, Nathan J. Hillson
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Publication number: 20120219585Abstract: The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.Type: ApplicationFiled: September 21, 2011Publication date: August 30, 2012Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Rahul Raman, Xiaoying Koh, Karthik Viswanathan, Ram Sasisekharan, Aarthi Chandrasekaran
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Publication number: 20100119494Abstract: This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Therefore, methods and compositions are provided for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided. Furthermore, the invention relates, in part, to tissues, and uses thereof, formed by the methods and compositions provided. Moreover, the invention also relates, in part, to methods of treatment using the methods and compositions provided.Type: ApplicationFiled: January 19, 2010Publication date: May 13, 2010Applicant: Massachusetts Institute of TechnologyInventors: SHILADITYA SENGUPTA, RAM SASISEKHARAN, NISHLA KEISER, DAVID EAVARONE, TANYEL KIZILTEPE BILGICER, AARTHI CHANDRASEKARAN, DAVID A. BERRY, KRISTINE HOLLEY
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Publication number: 20100061990Abstract: The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.Type: ApplicationFiled: August 14, 2007Publication date: March 11, 2010Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan
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Publication number: 20100004195Abstract: The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.Type: ApplicationFiled: January 2, 2009Publication date: January 7, 2010Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan
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Publication number: 20090269342Abstract: The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.Type: ApplicationFiled: January 2, 2009Publication date: October 29, 2009Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan
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Publication number: 20090081193Abstract: The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.Type: ApplicationFiled: January 3, 2008Publication date: March 26, 2009Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan
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Publication number: 20080241918Abstract: The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.Type: ApplicationFiled: August 14, 2007Publication date: October 2, 2008Inventors: Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan
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Publication number: 20070212786Abstract: In one aspect, the present invention provides a device and method for real-time, direct detection of heparin in buffer and in serum comprising a microfluidic field-effect device as an affinity biosensor. The sensor is based on an electrolyte-insulator-silicon structure, and is manufactured by a standard high-yield silicon microfabrication process. The binding of heparin to the sensor surface induces a change in the insulator-electrolyte surface potential, which is measured as a change in sensor capacitance. To ensure the binding selectivity, protamine and antithrombin III are used as affinity probes.Type: ApplicationFiled: September 29, 2006Publication date: September 13, 2007Inventors: Scott Manalis, Tzu Loh, Michel Godin, Nebojsa Milovic, Jonathan Behr, Aarthi Chandrasekaran, Ram Sasisekharan
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Publication number: 20070020243Abstract: This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Such modulation, in some aspects of the invention, is accomplished by agents that modulate glycosaminoglycans in the stem cell microenvironment (i.e., at or on the cell surface and/or in the extracellular matrix). Therefore, methods and compositions are provide for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided.Type: ApplicationFiled: January 12, 2006Publication date: January 25, 2007Applicant: Massachusetts Institute of TechnologyInventors: Shiladitya Sengupta, Ram Sasisekharan, Nishla Keiser, David Eavarone, Tanyel Kiziltepe Bilgicer, Aarthi Chandrasekaran, David Berry, Kristine Holley
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Publication number: 20060067927Abstract: The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.Type: ApplicationFiled: June 29, 2005Publication date: March 30, 2006Applicant: Massachusetts Institute of TechnologyInventors: Aarthi Chandrasekaran, Shiladitya Sengupta, David Berry, Kristine Holley, Ganlin Zhao, Ram Sasisekharan