Patents by Inventor Abdelhamid Elaissari
Abdelhamid Elaissari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8999362Abstract: The present invention relates to novel nanoencapsulated compositions, methods for making such compositions, and methods of repelling insects and other arthropod pests away from animals, including humans. The present invention has particular, though not sole, application to repelling insects including flies and mosquitoes. The inventive compositions may be used to repel arthropods from animals, humans, plants, soil, or building structures. The formulations also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents.Type: GrantFiled: January 28, 2013Date of Patent: April 7, 2015Assignee: Merial, Inc.Inventors: Jean Delaveau, Audrey Minost, Hatem Fessi, Marie-Alexandrine Bolzinger, Abdelhamid Elaissari
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Publication number: 20140213643Abstract: The present invention relates to novel nanoencapsulated compositions, methods for making such compositions, and methods of repelling insects and other arthropod pests away from animals, including humans. The present invention has particular, though not sole, application to repelling insects including flies and mosquitoes. The inventive compositions may be used to repel arthropods from animals, humans, plants, soil, or building structures. The formulations also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents.Type: ApplicationFiled: January 28, 2013Publication date: July 31, 2014Applicant: MERIAL LIMITEDInventors: Jean Delaveau, Audrey Minost, Hatem FESSI, Marie-Alexandrine BOLZINGER, Abdelhamid Elaissari
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Patent number: 8093026Abstract: The magnetic colloidal particles comprise a core and an envelope in which the core is magnetic and is coated with at least one polymer comprising functional groups X chosen from amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups, or mixtures thereof, at least one fraction of which has reacted with other functional groups of the envelope, and the envelope comprises a polymer bearing ionizable functional groups, Z and Z?, which may be identical or different, chosen from amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulfide, ?-halocarbonyl, sulfonic acid, maleimide, isocyanate and isothiocyanate groups, which have partially reacted with the functional groups X of the core. These magnetic colloidal particles can be used to isolate biological material.Type: GrantFiled: February 17, 2010Date of Patent: January 10, 2012Assignee: BiomerieuxInventors: Abdelhamid Elaissari, Bernard Mandrand, Thierry Delair, Doran Spencer, Ahmed Arkis
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Publication number: 20100209987Abstract: The magnetic colloidal particles comprise a core and an envelope in which the core is magnetic and is coated with at least one polymer comprising functional groups X chosen from amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups, or mixtures thereof, at least one fraction of which has reacted with other functional groups of the envelope, and the envelope comprises a polymer bearing ionizable functional groups, Z and Z?, which may be identical or different, chosen from amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulfide, ?-halocarbonyl, sulfonic acid, maleimide, isocyanate and isothiocyanate groups, which have partially reacted with the functional groups X of the core. These magnetic colloidal particles can be used to isolate biological material.Type: ApplicationFiled: February 17, 2010Publication date: August 19, 2010Applicant: BIOMERIEUXInventors: Abdelhamid Elaissari, Bernard Mandrand, Thierry Delair, Doran Spencer, Ahmed Arkis
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Patent number: 7700744Abstract: The magnetic colloidal particles comprise a core and an envelope in which the core is magnetic and is coated with at least one polymer comprising functional groups X chosen from amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups, or mixtures thereof, at least one fraction of which has reacted with other functional groups of the envelope, and the envelope comprises a polymer bearing ionizable functional groups, Z and Z?, which may be identical or different, chosen from amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulfide, ?-halocarbonyl, sulfonic acid, maleimide, isocyanate and isothiocyanate groups, which have partially reacted with the functional groups X of the core. These magnetic colloidal particles can be used to isolate biological material.Type: GrantFiled: December 30, 2005Date of Patent: April 20, 2010Assignee: BiomerieuxInventors: Abdelhamid Elaissari, Bernard Mandrand, Thierry Delair, Doran Spencer, Ahmed Arkis
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Publication number: 20090099342Abstract: The invention relates to a process for preparing composite particles by encapsulation of an organic-phase-depleted emulsion by polymerization, said emulsion consisting of droplets of inorganic emulsion comprising an organic phase and inorganic nanoparticles distributed in said organic phase, characterized in that the polymerization is carried out using, as the polymerization monomer, from 60% to 100% of at least one crosslinking agent and from 0% to 40% of at least one hydrophobic monomer, it being understood that at least 95% of the crosslinking agent(s) are hydrophobic. The invention further relates to the particles thus obtained, and their use in diagnostics.Type: ApplicationFiled: December 14, 2006Publication date: April 16, 2009Applicants: BIOMERIEUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Sebastien Braconnot, Abdelhamid Elaissari, Hanna Mouaziz
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Patent number: 7217457Abstract: The invention relates to composite particles comprising a hydrophobic polymer core and inorganic nanoparticles. Said hydrophobic polymer forms a polymer matrix inside which the inorganic nanoparticles are stabilized and distributed in a relatively homogenous manner. Said particles are at least partially surrounded by an amphophilic copolymer comprising a hydrophobic part and a hydrophilic part, said hydrophobic part being at least partially immobilized in the polymer matrix. The inventor also relates to the preparation method thereof, the conjugates comprising such particles and a ligand and the use of same in reactants and therapeutic compositions.Type: GrantFiled: May 6, 2002Date of Patent: May 15, 2007Assignees: Bio Merieux, Centre National de la Recherche ScientifiqueInventors: Abdelhamid Elaissari, Franck Montagne, Eric Bosc, Christian Pichot, Bernard Mandrand, Jérôme Bibette, Olivier Mondain-Monval
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Patent number: 7060804Abstract: The invention concerns a method for isolating proteins and/or protein and nucleic acid associations in a sample, comprising steps which consist in: contacting said sample and magnetic colloidal particles comprising a core and a coat wherein: the core is magnetic and is coated with at least a polymer comprising functional groups X selected among amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups or mixtures thereof, whereof at least one fraction has reacted with other functional groups of the coat, and the coat consists of a polymer bearing functional groups Z and Z?, capable of ionisation, identical or different, selected among amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulphide, ?-halogenocarbonyl, sulphonic acid, maleimide, isocyanate and isothiocyanate groups to form a mixture; incubating said mixture in predetermined conditions; and separating from the mixture the protein and/or protein and nucleic acid associatioType: GrantFiled: January 22, 2001Date of Patent: June 13, 2006Assignee: BiomerieuxInventors: Abdelhamid Elaissari, Bernard Mandrand, Thierry Delair, Doran Spencer, Ahmed Arkis
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Publication number: 20060105326Abstract: The magnetic colloidal particles comprise a core and an envelope in which the core is magnetic and is coated with at least one polymer comprising functional groups X chosen from amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups, or mixtures thereof, at least one fraction of which has reacted with other functional groups of the envelope, and the envelope comprises a polymer bearing ionizable functional groups, Z and Z?, which may be identical or different, chosen from amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulfide, ?-halocarbonyl, sulfonic acid, maleimide, isocyanate and isothiocyanate groups, which have partially reacted with the functional groups X of the core. These magnetic colloidal particles can be used to isolate biological material.Type: ApplicationFiled: December 30, 2005Publication date: May 18, 2006Applicant: BIOMERIEUXInventors: Abdelhamid Elaissari, Bernard Mandrand, Thierry Delair, Doran Spencer, Ahmed Arkis
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Patent number: 7001589Abstract: The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.Type: GrantFiled: December 28, 2004Date of Patent: February 21, 2006Assignees: Bio Merieux, Centre National de la Recherche ScientifiqueInventors: Olivier Mondain-Monval, Abdelhamid Elaissari, Eric Bosc, Christian Pichot, Bernard Mandrand, Jérôme Bibette
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Publication number: 20050137334Abstract: The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.Type: ApplicationFiled: December 28, 2004Publication date: June 23, 2005Applicants: Bio Merieux, Centre National De La Recherche ScientifiqueInventors: Olivier Mondain-Monval, Abdelhamid Elaissari, Eric Bosc, Christian Pichot, Bernard Mandrand, Jerome Bibette
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Patent number: 6866838Abstract: The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N—N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.Type: GrantFiled: November 6, 2000Date of Patent: March 15, 2005Assignees: Bio Merieux, Centre National de la Recherche ScientifiqueInventors: Olivier Mondain-Monval, Abdelhamid Elaissari, Eric Bosc, Christian Pichot, Bernard Mandrand, Jérôme Bibette
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Publication number: 20040115433Abstract: The invention relates to composite particles comprising a hydrophobic polymer core and inorganic nanoparticles. Said hydrophobic polymer forms a polymer matrix inside which the inorganic nanoparticles are stabilised and distributed in a relatively homogenous manner. Said particles are at least partially surrounded by an amphiphilic copolymer comprising a hydrophobic part and a hydrophilic part, said hydrophobic part being at least partially immobilised in the polymer matrix. The invention also relates to the preparation method thereof, the conjugates comprising such particles and a ligand and the use of same in reactants and therapeutic compositions.Type: ApplicationFiled: February 4, 2004Publication date: June 17, 2004Inventors: Abdelhamid Elaissari, Franck Montagne, Eric Bosc, Christian Pichot, Berbard Mandrand, Jerome Bibette, Olivier Mondain-Monval
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Patent number: 6737235Abstract: A method for aqueous phase nucleic acid isolation from a sample, comprising a step of nucleic acid adsorption on a particulate substrate, is disclosed. The method comprises an adsorption reagent preparation step (a) that includes a sol consisting of a aqueous continuous phase and a dispersed particulate substrate phase including a functionalized particulate polymer prepared by polymerizing (1) a first water-soluble acrylamide or acrylamide derivative monomer, (2) at least one cross-linking agent and (3) at least one second water-soluble, cationic and functional monomer, said polymer having a predetermined lower critical solubility temperature (LCST) of 25-45° C.Type: GrantFiled: November 10, 1997Date of Patent: May 18, 2004Assignee: Bio MerieuxInventors: Philippe Cros, Abdelhamid Elaissari, Claude Mabilat, Christian Pichot, Marc Rodrigue, Lise Santoro
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Publication number: 20030175691Abstract: The invention concerns a method for isolating proteins and/or protein and nucleic acid associations in a sample, comprising steps which consist in: contacting said sample and magnetic colloidal particles comprising a core and a coat wherein: the core is magnetic and is coated with at least a polymer comprising functional groups X selected among amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups or mixtures thereof, whereof at least one fraction has reacted with other functional groups of the coat, and the coat consists of a polymer bearing functional groups Z and Z′, capable of ionisation, identical or different, selected among amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulphide, &agr;-halogenocarbonyl, sulphonic acid, maleimide, isocyanate and isothiocyanate groups to form a mixture; incubating said mixture in predetermined conditions; and separating from the mixture the protein and/or protein and nucleic acidType: ApplicationFiled: January 13, 2003Publication date: September 18, 2003Inventors: Abdelhamid Elaissari, Bernard Mandrand, Thierry Delair, Doran Spencer, Ahmed Arkis
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Patent number: 6521341Abstract: The invention concerns magnetic and heat-sensitive particles having a predetermined size between 0.05 and 10 &mgr;m, each particle comprising: an inner composite core consisting of a solid organic or inorganic particle, containing within it a magnetic filler; an outer coati based on a polymer capable of interacting with at least a biological molecule, the outer polymer is heat-sensitive and has a predetermined low critical solubility temperature (LCST) ranging between 10 and 100° C. and preferably between 20 and 60° C. The invention also concerns methods for obtaining said particles and their uses. The particles are characterized in that there is an intermediate layer between the inner core and the outer layer isolating said inner core magnetic filler with respect to said functionalized outer layer. Said invention is particularly useful for separating proteins and/or nucleic acids.Type: GrantFiled: September 21, 2000Date of Patent: February 18, 2003Assignee: Bio MerieuxInventors: Abdelhamid Elaissari, Christian Pichot, Bernard Mandrand
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Publication number: 20020160526Abstract: The invention concerns a method for isolating a target biological material contained in a sample, consisting in the following steps: providing a capture phase, in microparticulate or linear form, consisting of at least a first particulate or linear polymer, with apparent hydrophile character and first complexing groups, the latter being bound by co-ordination to a first transition metal, which is itself bound to a frist biological entity capable of specifically recongnising the target biological material; contacting said target biological material with at least the capture phase; and detecting the capture phase-target biological material complex, optionally with a detection phase, in microparticulate or linear form, and consisting of at least a second particulate or linear polymer, with apparent hydrophile character and second complexing groups, the latter being bound by co-ordination to a second transition metal, which is itself bound to a second biological entity capable of specifically recognizing the targType: ApplicationFiled: January 7, 2000Publication date: October 31, 2002Inventors: ABDELHAMID ELAISSARI, DAVID DURACHER, CHRISTIAN PICHOT, FRANCOIS MALLET, ARMELLE NOVELLI-ROUSSEAU
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Patent number: 6133047Abstract: The superparamagnetic monodispersed particles comprise a core of a first polymer, an internal layer of a second polymer coating the core and in which a magnetic material is distributed, and an external layer of a third polymer coating the magnetic layer and capable of interacting with at least one biological molecule. At least the second polymer is heat sensitive and has a predetermined lower critical solubility temperature (LCST) of 15-65.degree. C. These particles may be used to isolate at least one biological molecule from a liquid specimen.Type: GrantFiled: January 15, 1998Date of Patent: October 17, 2000Assignee: Bio MerieuxInventors: Abdelhamid Elaissari, Christian Pichot, Bernard Mandrand, Florence Sauzedde
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Patent number: 6033853Abstract: Kit for detecting a specific target nucleic acid sequence using a labeled probe with signal amplification, which comprises in containers (i) a probe labeled with a tracer (ii) a suspension of insoluble particles on which are immobilized at least one series of oligonucleotide units all of which are identical and contain at least one sequence that specifically hybridize with the target nucleic acid sequence and at one sequence that specifically hybridize with tracer labeled probe. A method using the kit is also described.Type: GrantFiled: January 8, 1997Date of Patent: March 7, 2000Assignee: Bio MerieuxInventors: Thierry Delair, Abdelhamid Elaissari, Marie-Helene Charles, Bernard Mandrand