Patents by Inventor Abdelsattar Omar

Abdelsattar Omar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZALDEHYDE COMPOUNDS WITH DIRECT POLYMER DESTABILIZING EFFECTS TO TREAT SICKLE CELL DISEASE
    Publication number: 20240174612
    Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).
    Type: Application
    Filed: November 3, 2023
    Publication date: May 30, 2024
    Inventors: Martin SAFO, Yan ZHANG, Andrew FLEISCHMAN, David LIGHT, Moustafa EL-ARABY, Abdelsattar OMAR, Osheiza ABDULMALIK
  • BENZALDEHYDE COMPOUNDS WITH DIRECT POLYMER DESTABILIZING EFFECTS TO TREAT SICKLE CELL DISEASE
    Publication number: 20240109843
    Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).
    Type: Application
    Filed: November 3, 2023
    Publication date: April 4, 2024
    Inventors: Martin SAFO, Yan ZHANG, Piyusha Pradeep PAGARE, Guoyan XU, Mohini GHATGE, Jurgen VENITZ, Osheiza ABDULMALIK, Andrew FLEISCHMAN, David LIGHT, Moustafa EL-ARABY, Abdelsattar OMAR
  • Potent antimicrobial compounds with a pyridazine nucleus
    Patent number: 11648248
    Abstract: Anti-microbial compounds having a pyridazine nucleus are provided. The compounds have anti-microbial (anti-biotic) properties and are used to treat infections caused by microbes, especially bacteria that are resistant to known antibiotics e.g. drug resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA).
    Type: Grant
    Filed: January 12, 2022
    Date of Patent: May 16, 2023
    Assignee: King Abdulaziz University
    Inventors: Moustafa El-Araby, Khaled Abouzid, Abdelsattar Omar, Maiy Jaballah, Khadijah Mohammad
  • Surface-modified emulsomes for intranasal delivery of drugs
    Patent number: 11234933
    Abstract: Emulsome compositions comprising phosphatidylcholine, cholesterol, tristearin, and one or more lipophilic bioactive agents such as vinpocetine are provided. The emulsomes may further comprise surface modifications of either [N-(carbonyl-methoxypropylethyleneglycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt] (MPEG-DSPE) for peglyation or stearylamine for cationization. Methods of improving brain delivery of lipophilic bioactive agents by intranasally administering such emulsome compositions are also provided.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: February 1, 2022
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Hibah M. Aldawsari, Shaimaa M. Badr-Eldin, Nourah Y. Assiri, Abdelsattar Omar
  • Instantly dissolving buccal films
    Patent number: 11147765
    Abstract: Instantly dissolving buccal fims comprising certain pH modifiers, film formers, film modifiers, and solubilizing agents are provided. Methods of providing the buccal film to enhance the dissolution and bioavailability of low solubility basic drugs, such as dapoxetine hydrochloride, in a subject are also provided.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: October 19, 2021
    Assignee: King Abdulaziz University
    Inventors: Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Abdelsattar Omar
  • Surface-modified emulsomes for intranasal delivery of drugs
    Patent number: 11058637
    Abstract: Emulsome compositions comprising phosphatidylcholine, cholesterol, tristearin, and one or more lipophilic bioactive agents such as vinpocetine are provided. The emulsomes may further comprise surface modifications of either [N-(carbonyl-methoxypropylethyleneglycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt] (MPEG-DSPE) for peglyation or stearylamine for cationization. Methods of improving brain delivery of lipophilic bioactive agents by intranasally administering such emulsome compositions are also provided.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: July 13, 2021
    Assignee: King Abdulaziz University
    Inventors: Hibah M. Aldawsari, Shaimaa M. Badr-Eldin, Nourah Y. Assiri, Abdelsattar Omar
  • Instantly dissolving buccal films
    Patent number: 10973760
    Abstract: Instantly dissolving buccal films comprising certain pH modifiers, film formers, film modifiers, and solubilizing agents are provided. Methods of providing the buccal film to enhance the dissolution and bioavailability of low solubility basic drugs, such as dapoxetine hydrochloride, in a subject are also provided.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: April 13, 2021
    Assignee: King Abdulaziz University
    Inventors: Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Abdelsattar Omar