Abstract: Described herein are nanoparticle compositions and methods for pH-specific release and targeted delivery of therapeutics with enhanced bioavailability. In some embodiments, methods are described for generating carbon nanoparticles (CNPs) that can release payload in acidic pH environments.

Abstract: Water soluble graphene oxide nanoparticles (GO) are provided having graphene sheets containing carboxylic and hydroxyl groups. The diameter of the GO when present in a closed form range from about 40 nm to 120 nm. Eco-friendly methods are provided for producing the GO. Methods for reversible encapsulation of a molecule within water soluble carbon nanoparticles (wsCNP) including the GO nanoparticles are provided that allow for delivery of the wsCNP loaded with therapeutic and/or imaging agents to a subject in need by releasing the therapeutic/imaging agent upon an increase in pH above about 7.2. The wsCNP have been shown to cross the blood brain barrier in a mouse model of vascular dementia, and methods are provided for delivering the wsCNP loaded with a therapeutic and/or imaging molecule to the brain.

Abstract: Water soluble graphene oxide nanoparticles (GO) are provided having graphene sheets containing carboxylic and hydroxyl groups. The diameter of the GO when present in a closed form range from about 40 nm to 120 nm. Eco-friendly methods are provided for producing the GO. Methods for reversible encapsulation of a molecule within water soluble carbon nanoparticles (wsCNP) including the GO nanoparticles are provided that allow for delivery of the wsCNP loaded with therapeutic and/or imaging agents to a subject in need by releasing the therapeutic/imaging agent upon an increase in pH above about 7.2. The wsCNP have been shown to cross the blood brain barrier in a mouse model of vascular dementia, and methods are provided for delivering the wsCNP loaded with a therapeutic and/or imaging molecule to the brain.

Abstract: Water soluble graphene oxide nanoparticles (GO) are provided having graphene sheets containing carboxylic and hydroxyl groups. The diameter of the GO when present in a closed form ranges from about 40 nm to 120 nm. Eco-friendly methods are provided for producing the GO. Methods for reversible encapsulation of a molecule within water soluble carbon nanoparticles (wsCNP) including the GO nanoparticles are provided that allow for delivery of the wsCNP loaded with therapeutic and/or imaging agents to a subject in need by releasing the therapeutic/imaging agent upon an increase in pH above about 7.2. The wsCNP have been shown to cross the blood brain barrier in a mouse model of vascular dementia, and methods are provided for delivering the wsCNP loaded with a therapeutic and/or imaging molecule to the brain.

Abstract: Modeling a governance process of optimizing a portfolio of services in a governed SOA and generating, in dependence upon the modeled governance process, one or more automation modules, each automation module including a module of computer program instructions that supports performance of one or more steps of the modeled governance process, where the modeled governance process includes determining whether a collection of service artifacts matches one or more service artifacts stored in a service registry; if no service artifacts stored in the service registry match the collection of service artifacts, initiating creation of a service in accordance with the collection of service artifacts; if one or more service artifacts stored in the service registry match the collection of service artifacts: selecting, in dependence upon predefined action selection criteria, a service administration action to perform; obtaining approval of the selected service administration action; and initiating the selected service admini

Abstract: Provided herein are approaches to re-factor, rationalize, and prioritize a service model, and to assess service exposure in the service model. At least one approach provides: determining a granularity of a service of the service model; re-factoring and refining a service portfolio and a hierarchy of the service model; adapting a Service Litmus Test (SLT) and service exposure scope to the service model; applying at least one Service Litmus Test (SLT) to the service model; and verifying, with each affected stakeholder associated with the service model, that the service model achieves business and technical needs based on the results of the SLTs, which include tests to make exposure decisions, including whether to expose the service or not expose the service, wherein the service represent business capabilities and are placed in the hierarchy of the service model which represents the granularity.

Abstract: Water soluble graphene oxide nanoparticles (GO) are provided having graphene sheets containing carboxylic and hydroxyl groups. The diameter of the GO when present in a closed form ranges from about 40 nm to 120 nm. Eco-friendly methods are provided for producing the GO. Methods for reversible encapsulation of a molecule within water soluble carbon nanoparticles (wsCNP) including the GO nanoparticles are provided that allow for delivery of the wsCNP loaded with therapeutic and/or imaging agents to a subject in need by releasing the therapeutic/imaging agent upon an increase in pH above about 7.2. The wsCNP have been shown to cross the blood brain barrier in a mouse model of vascular dementia, and methods are provided for delivering the wsCNP loaded with a therapeutic and/or imaging molecule to the brain.

Abstract: Provided herein are approaches to re-factor, rationalize, and prioritize a service model, and to assess service exposure in the service model. At least one approach provides: determining a granularity of a service of the service model; re-factoring and refining a service portfolio and a hierarchy of the service model; adapting a Service Litmus Test (SLT) and service exposure scope to the service model; applying at least one Service Litmus Test (SLT) to the service model; and verifying, with each affected stakeholder associated with the service model, that the service model achieves business and technical needs based on the results of the SLTs, which include tests to make exposure decisions, including whether to expose the service or not expose the service, wherein the service represent business capabilities and are placed in the hierarchy of the service model which represents the granularity.

Abstract: Provided herein are approaches to re-factor, rationalize, and prioritize a service model, and to assess service exposure in the service model. At least one approach provides: determining a granularity of one or more services of the service model; re-factoring and refining a service portfolio and a hierarchy of the service model; adapting a Service Litmus Test (SLT) and service exposure scope to the service model; applying Service Litmus Tests (SLTs) to the service model; and verifying, with each affected stakeholder associated with the service model, that the service model achieves business and technical needs based on the results of the SLTs, which include tests to make exposure decisions, including whether to expose the service or not expose the service, wherein the service represent business capabilities and are placed in the hierarchy of the service model which represents the granularity.

Abstract: A method, system, and computer program product for improving software component placement on software execution platforms are provided in the illustrative embodiments. A computer determines whether a code corresponding to the software component includes business process logic. The computer determines a granularity level of the code. The granularity level of the code is a categorization of the code according to whether a number of external references in the code exceed a threshold value. The computer, responsive to determining the granularity level of the code, recommends placement of a first portion of the code on a first platform in the set of software execution platforms.

Abstract: A method of dynamically offering upgraded services in a network comprising functions, the method comprising a computer performing the steps of: applying a similar functionality analysis on the functions of a network; retrieving the plurality of functions stored by the similar functionality analysis from the repository, and creating a pivot table; categorizing the functions within the pivot table; filtering the pivot table by a functional area of the pivot table; recreating the pivot table based on the functional area; and differentiating the exposable functions within the pivot table from non-exposable functions by attributes of the functions.

Abstract: Techniques are provided for representing and configuring flexible and extensible presentation patterns based on fine-grained architectural building blocks (ABBs). The techniques include defining ABBs, modeling the ABBs in a uniform manner, and creating at least one template using the ABBs, wherein the at least one template includes at least one of pre-configured static characteristics and user-specified service characteristics. In an embodiment of the invention, an exemplary method for designing and managing fine-grained ABBs can include identifying ABBs to compose an architecture for facilitating presentation and interaction between consumers and other elements in a solution, analyzing the ABBs to monitor computing resources used by individual ABBs, selecting a number of running instances of the ABBs based on (i) requests of a pertinent entity and (ii) available resources, and managing life-cycles of ABBs.

Abstract: A technique and associated mechanism that guides the user through a set of questions relating to operation rules used in the design of Service Oriented Architecture Systems (SOAs). The questions are related to key aspects of a solution—security, maintenance frequency, usage demand/performance and complexity. Preferably, the questions are yes-or-no questions. Based on the answers provided, an appropriate path will be selected categorize into an appropriate category. The category of the rule will require, or at least suggest, the SOA component into which the rule will be implemented when it is implemented by the SOA designer. the technique is technology specific agnostic and helps in selecting an appropriate tool/platform in a standard and consistent manner.

Abstract: Provided herein are approaches to re-factor, rationalize, and prioritize a service model, and to assess service exposure in the service model. At least one approach provides: determining a granularity of one or more services of the service model; re-factoring and refining a service portfolio and a hierarchy of the service model; adapting a Service Litmus Test (SLT) and service exposure scope to the service model; applying Service Litmus Tests (SLTs) to the service model; and verifying, with each affected stakeholder associated with the service model, that the service model achieves business and technical needs based on the results of the SLTs, which include tests to make exposure decisions, including whether to expose the service or not expose the service, wherein the service represent business capabilities and are placed in the hierarchy of the service model which represents the granularity.

Abstract: Modeling a governance process of optimizing a portfolio of services in a governed SOA and generating, in dependence upon the modeled governance process, one or more automation modules, each automation module including a module of computer program instructions that supports performance of one or more steps of the modeled governance process, where the modeled governance process includes determining whether a collection of service artifacts matches one or more service artifacts stored in a service registry; if no service artifacts stored in the service registry match the collection of service artifacts, initiating creation of a service in accordance with the collection of service artifacts; if one or more service artifacts stored in the service registry match the collection of service artifacts: selecting, in dependence upon predefined action selection criteria, a service administration action to perform; obtaining approval of the selected service administration action; and initiating the selected service admini

Abstract: In general, embodiments of the present invention classify cloud computing environments based on the abstraction layers that the cloud computing environments span and by combining the re-usable capabilities/logical components from these layers. In a typical embodiment, input (e.g., a set of requirements, a set of preferences, a set of costs parameters, and/or a request for feedback) pertaining to a set of services available in the networked computing environment is received from a requester via a network node. Based on the input, a set of capabilities and a corresponding set of logical components of the networked computing environment are identified. Thereafter, a set of providers capable of providing at least one of the set of services is identified and ranked. The set of logical components is then configured to provide the set of services according to the input, and made available to the requester.

Abstract: Modeling a governance process of optimizing a portfolio of services in a governed SOA and generating, in dependence upon the modeled governance process, one or more automation modules, each automation module including a module of computer program instructions that supports performance of one or more steps of the modeled governance process, where the modeled governance process includes determining whether a collection of service artifacts matches one or more service artifacts stored in a service registry; if no service artifacts stored in the service registry match the collection of service artifacts, initiating creation of a service in accordance with the collection of service artifacts; if one or more service artifacts stored in the service registry match the collection of service artifacts: selecting, in dependence upon predefined action selection criteria, a service administration action to perform; obtaining approval of the selected service administration action; and initiating the selected service admini

Abstract: The method of the present invention to re-factor, rationalize, and prioritize a service model and to assess service exposure in the service model is illustrated. The service model is reviewed and re-factored and the service portfolio and service hierarchy are refined, exposure decisions are made, and finally the service model and its constituent parts are rationalized based on the re-factoring and exposure decisions. Another technique called Service Litmus Tests (SLTs) is leveraged during service re-factoring and rationalization. SLTs are set of gating criteria to select and filter a set of (candidate) services from the service portfolio for exposure. A Service Exposure Assessment Toolkit (SEAT) is also presented in the present invention. SEAT is a mathematical model to facilitate making exposure decisions for services and prioritizing the services in the service model.

Abstract: Modeling a governance process of establishing a subscription to a deployed service in a governed Service Oriented Architecture (‘SOA’) and generating, in dependence upon the modeled governance process, one or more automation modules, each automation module comprising a module of computer program instructions that, when executed by a computer processor, supports performance of one or more steps of the modeled governance process, where the modeled governance process includes collecting available service artifacts associated with a deployed service; determining whether the deployed service meets predefined functional requirements; if the deployed service meets the predefined functional requirements, determining whether the deployed service meets predefined non-functional requirements if the deployed service meets the predefined non-functional requirements, creating a subscription request; requesting approval of the subscription request; and if approval is received, creating a subscription to the deployed service

Abstract: A method of dynamically offering upgraded services in a network comprising functions, the method comprising a computer performing the steps of: applying a similar functionality analysis on the functions of a network; retrieving the plurality of functions stored by the similar functionality analysis from the repository, and creating a pivot table; categorizing the functions within the pivot table; filtering the pivot table by a functional area of the pivot table; recreating the pivot table based on the functional area; and differentiating the exposable functions within the pivot table from non-exposable functions by attributes of the functions.