Abstract: The present invention relates to a polyurethane polymer prepared from a mixture comprising: (a) at least one polyol of formula (I), wherein at least three of X1, X2, X3, X4 and X5 are each independently an OH-terminated polyoxyalkylene group, and the remainder of X1, X2, X3. X4 and X5 are each independently H or absent, and Z is a central linking unit; (b) at least one di- or poly-isocyanate; and (c) optionally at least one OH-terminated chain extender. Further aspects of the invention relate to a process for preparing a polyurethane, and to a process for preparing a contact lens.

Abstract: There is provided a polyurethane xerogel prepared from a mixture comprising: (a) at least one isocyanate, (b) at least one silicone containing compound of formula J: wherein at least one group represents a hydrocarbyl group and p represents an integer of from 1 to 40, or at least one R2 group represents a hydrocarbyl group and q represents an integer of from 1 to 40; and at least one R3 group represents a hydrocarbyl group and w represents an integer of from 1 to 40, or at least one R4 group represents a hydrocarbyl group and y represents an integer of from 1 to 40; (c) optionally one or more additional components; wherein the isocyanate and silicone containing compound are reacted under substantially anhydrous conditions. There is also provided a contact lens formed from the polyurethane xerogel.

Abstract: Bioavailable liquid softgel fill compositions comprising a) fexofenadine or a fexofenadine salt; b) a matrix comprising a pharmaceutically acceptable poly(alkylene glycol), a pharmaceutically acceptable alkylene glycol, a pharmaceutically acceptable polymeric solubilizing agent, and a pharmaceutically acceptable surfactant; and c) a pharmaceutically acceptable acidulant are disclosed. Also disclosed are methods for the preparation of such fill compositions, and softgel capsules containing the bioavailable liquid fill composition.

Abstract: The invention provides methods and materials for use in the detection of influenza viruses which utilise a nanoparticle, for example gold nanoparticle, probe comprising a plurality of glycoconjugate ligands, each glyconjugate ligand (GL) having a plurality of sialic-acid containing recognition group (Y) coupled to the nanoparticle via a multivalent core (X), wherein the multivalent core (X) is a trivalent core, whereby there are 3 recognition groups per ligand, wherein the recognition groups on the bioconjugate specifically bind to the hemagglutinin on the target influenza virus. The probes may include further ligands bound to the nanoparticle which do not bind specifically to an influenza virus—for example polyethylene glycol groups. These can modulate density of the glycoconjugate ligand on the surface of the nanoparticle. Binding of probes is detected by a plasmonic signal which is specific to the influenza virus.

Abstract: The present invention relates to a thermoplastic polyurethane contact lens prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; and (c) at least one diol of formula (I): wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a contact lens.

Abstract: A mandrel for transporting a set of substrates includes a rod having a free end and a fixed end, the fixed end configured to be coupled to a transport mechanism. A series of spacer elements are arranged on the rod to keep the set of substrates seated on the rod in respective fixed positions with a last spacer element nearest to the fixed end. A notch is arranged on the rod between the fixed end and the last spacer element configured to catch a substrate that becomes unseated from the last spacer element.

Abstract: There is provided a polyurethane xerogel prepared from a mixture comprising: (a) at least one isocyanate, (b) at least one silicone containing compound of formula J: wherein at least one group represents a hydrocarbyl group and p represents an integer of from 1 to 40, or at least one R2 group represents a hydrocarbyl group and q represents an integer of from 1 to 40; and at least one R3 group represents a hydrocarbyl group and w represents an integer of from 1 to 40, or at least one R4 group represents a hydrocarbyl group and y represents an integer of from 1 to 40; (c) optionally one or more additional components; wherein the isocyanate and silicone containing compound are reacted under substantially anhydrous conditions. There is also provided a contact lens formed from the polyurethane xerogel.

Abstract: The present invention relates to a polyurethane polymer composition comprising polyethyleneglycol dialkyl ether. There is also provided a process for preparing a polyurethane. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: i. preparing a mixture of a. at least one polyethylene glycol or at least one polyol of formula I, wherein at least three of X1, X2, X3, X4 and X5 are each independently an OH-terminated group, and the remainder of X1, X2, X3, X4 and X5 are each independently H or absent, and Z is a central linking unit, a. at least one di- or poly-isocyanate, b. optionally at least one OH-terminated chain extender, and c. at least one polyethyleneglycol dialkyl ether; ii. dispensing the reaction mixture formed in step i) into a mold; iii. allowing the reaction mixture to react and cure; iv. removing the molded article from the mold; and v. hydrating the molded article.

Abstract: The present invention relates to a polyurethane prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; (c) at least one polydialkyl siloxane diol; and (d) at least one diol of formula (I) wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate, polydialkyl siloxane diol and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a polyurethane.

Abstract: A pharmaceutical formulation contains 10-60% by weight acetaminophen as the only active ingredient and a solvent system for dissolving the acetaminophen. The formulation is free of any ionizing agent and its solvent system includes water, polyethylene glycol, and polyvinylpyrrolidone that is 2-50% by weight and has a molecular weight of 2,000 to 1,500,000. Also disclosed is another acetaminophen formulation containing polyvinylpyrrolidone as high as 25-50% by weight.

Abstract: A method for controlling pulsed power that includes measuring a first pulse of power from a power amplifier to obtain data. The method also includes generating a first signal to adjust a second pulse of delivered power, the first signal correlated to the data to minimize a power difference between a power set point and a substantially stable portion of the second pulse. The method also includes generating a second signal to adjust the second pulse of delivered power, the second signal correlated to the data to minimize an amplitude difference between a peak of the second pulse and the substantially stable portion of the second pulse.

Abstract: A clean room conveyor comprises a first guide rail and a plurality of motors coupled to the first guide rail, and a plurality of drive roller pairs. Each drive roller pair comprises two drive rollers, with a corresponding one of the plurality of motors disposed between the two drive rollers and applying torque to both of the two drive rollers.

Abstract: A method for controlling pulsed power that includes measuring a first pulse of power from a power amplifier to obtain data. The method also includes generating a first signal to adjust a second pulse of delivered power, the first signal correlated to the data to minimize a power difference between a power set point and a substantially stable portion of the second pulse. The method also includes generating a second signal to adjust the second pulse of delivered power, the second signal correlated to the data to minimize an amplitude difference between a peak of the second pulse and the substantially stable portion of the second pulse.

Abstract: A pharmaceutical formulation contains 10-60% by weight acetaminophen as the only active ingredient and a solvent system for dissolving the acetaminophen. The formulation is free of any ionizing agent and its solvent system includes water, polyethylene glycol, and polyvinylpyrrolidone that is 2-50% by weight and has a molecular weight of 2,000 to 1,500,000. Also disclosed is another acetaminophen formulation containing polyvinylpyrrolidone as high as 25-50% by weight.

Abstract: The present invention relates to a method for preparing a suspension for the encapsulation of heat and moisture sensitive substances in capsules, sachets, droplets and food compositions. It also relates to methods for encapsulating, to the encapsulated products and to methods for storing the encapsulated products. The invention is extremely suitable for the encapsulation of microbial cultures. Cultures encapsulated in capsules prepared according to the method of the invention, will stay stable for a long time. At 25 degrees C. they show a stability reduction of less than 1 log per month.

Abstract: Liquid softgel fill formulations include (i) 26-32% by weight acetaminophen, (ii) 47-51% by weight polyethylene glycol having an average molecular weight of 200-800, (iii) 3-7% by weight propylene glycol, (iv) 9-13% by weight Povidone K17, and (v) 6-10% by weight purified water. The fill formulations are free of alkali metal ions. Also disclosed are a method of preparing the above-described fill formulations and softgel capsules containing the same fill formulations.

Abstract: The present invention relates to a polyurethane polymer prepared from a mixture comprising: (a) at least one polyol of formula (I), wherein at least three of X1, X2, X3, X4 and X5 are each independently an OH-terminated polyoxyalkylene group, and the remainder of X1, X2, X3. X4 and X5 are each independently H or absent, and Z is a central linking unit; (b) at least one di- or poly-isocyanate; and (c) optionally at least one OH-terminated chain extender. Further aspects of the invention relate to a process for preparing a polyurethane, and to a process for preparing a contact lens.

Abstract: The present invention relates to a polyurethane polymer composition comprising polyethyleneglycol dialkyl ether. There is also provided a process for preparing a polyurethane. The invention also relates to a process for preparing a polyurethane xerogel in the form of a molded article, said process comprising the steps of: i. preparing a mixture of a. at least one polyethylene glycol or at least one polyol of formula (I), wherein at least three Of X1, X2, X3, X4 and X5 are each independently an OH-terminated group, and the remainder of X1, X2, X3, X4 and X5 are each independently H or absent, and Z is a central linking unit, a. at least one di- or poly-isocyanate, b. optionally at least one OH-terminated chain extender, and c. at least one polyethyleneglycol dialkyl ether; ii. dispensing the reaction mixture formed in step i) into a mold; iii. allowing the reaction mixture to react and cure; iv. removing the molded article from the mold; and v. hydrating the molded article.

Abstract: The present invention relates to a polyurethane prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; (c) at least one polydialkyl siloxane diol; and (d) at least one diol of formula (I) wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate, polydialkyl siloxane diol and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a polyurethane.

Abstract: The present invention relates to a thermoplastic polyurethane contact lens prepared from a mixture comprising: (a) at least one polyethylene glycol; (b) at least one di-isocyanate; and (c) at least one diol of formula (I): wherein n is an integer from 1 to 25; wherein the polyethylene glycol, di-isocyanate and diol are reacted under substantially anhydrous conditions. Further aspects of the invention relate to a process for preparing a contact lens.