Patents by Inventor Abhijit KALE

Abhijit KALE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR ACTIVATING INVARIANT NATURAL KILLER T-CELLS AND METHODS OF USE IN ELIMINATING INFLAMMATORY SENESCENT CELLS
    Publication number: 20240025936
    Abstract: Compounds for activating invariant natural killer T cells (iNKT) cells are provided. Compounds according to certain embodiments activate iNKT cells and induce an increase in the production of one or more cytokines, such as IFN-?, IL-2, IL-4, IL-6 and TNF?. In some embodiments, activated iNKT cells are used to selectively reduce the presence of or eliminate inflammatory senescent cells, such as senescent cells having an inflammatory secretome (SASP). Methods for activating iNKT cells by contacting an iNKT cell with an amount of the subject compounds and selectively reducing the presence of or eliminating senescent cells with activated iNKT cells are also described. Compositions for practicing the subject methods are also described.
    Type: Application
    Filed: August 30, 2023
    Publication date: January 25, 2024
    Applicant: Deciduous Therapeutics, Inc.
    Inventors: Matthew Duncton, Thomas Bobinski, Ajit Shah, Naze Gul AVCI, Abhijit Kale, Rachel Hatano, John Galloway, Scott Armstrong, Robin Mansukhani, Jasmine Denny
  • Biomarkers for detecting senescent cells
    Patent number: 11814680
    Abstract: The present invention provides a method of detecting senescent cells or diagnosing cellular senescence in a subject wherein the level of one or more selected miRNAs is quantified in a sample from said subject.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: November 14, 2023
    Assignees: BUCK INSTITUTE FOR RESEARCH ON AGING, UNIVERSITÄT FÜR BODENKULTUR WIEN
    Inventors: Johannes Grillari, Matthias Hackl, Judith Campisi, Abhijit Kale
  • NOVEL BIOMARKERS FOR DETECTING SENESCENT CELLS
    Publication number: 20220228213
    Abstract: The present invention provides a method of detecting senescent cells or diagnosing cellular senescence in a subject wherein the level of one or more selected miRNAs is quantified in a sample from said subject.
    Type: Application
    Filed: June 26, 2018
    Publication date: July 21, 2022
    Inventors: Johannes GRILLARI, Matthias HACKL, Judith CAMPISI, Abhijit KALE