Patents by Inventor Abhik Saha

Abhik Saha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide antagonists for inhibiting heat shock protein (Hsp 16.3) of
    Patent number: 7569537
    Abstract: A process to identify peptide antagonists of Hsp16.3, a chaperon protein necessary for the survival of Mycobacterium tuberculosis in the dormant phase is described. Affinity selection of a 7-mer and a 12-mer random peptide libraries displayed on bacteriophage M13 was performed using recombinant Hsp16.3 as template and two peptide phage clones, which bind to the Hsp16.3 protein were identified. Synthetic peptides corresponding to the peptide sequences displayed on these phage clones were able to specifically bind and inhibit the chaperone function of Hsp16.3 in vitro in a dose dependent manner. The corresponding inhibitory effect of these peptides on the chaperon activity of alphaB-crystallin, a constituent of human eye lens and a homologue of Hsp16.3, was found to be substantially less. These peptide inhibitors, or similar inhibitors generated by the process described, which specifically target Hsp16.3, can hence be used as lead compounds to obtain better therapeutics against latent tuberculosis.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: August 4, 2009
    Assignee: Council of Scientific and Industrial Research
    Inventors: Sujoy K. Das Gupta, Abhik Saha, Archna Pathak Sharma, Siddhartha Roy, Bhabatarak Bhattacharya, Pinakpani Chakrabarti
  • Peptide antagonists for inhibiting heat shock protein (Hsp 16.3) of mycobacterium tuberculosis
    Publication number: 20070037211
    Abstract: A process to identify peptide antagonists of Hsp16.3, a chaperon protein necessary for the survival of Mycobacterium tuberculosis in the dormant phase is described. Affinity selection of a 7-mer and a 12-mer random peptide libraries displayed on bacteriophage M13 was performed using recombinant Hsp16.3 as template and two peptide phage clones, which bind to the Hsp16.3 protein were identified. Synthetic peptides corresponding to the peptide sequences displayed on these phage clones were able to specifically bind and inhibit the chaperone function of Hsp16.3 in vitro in a dose dependent manner. The corresponding inhibitory effect of these peptides on the chaperon activity of alphaB-crystallin, a constituent of human eye lens and a homologue of Hsp16.3, was found to be substantially less. These peptide inhibitors, or similar inhibitors generated by the process described, which specifically target Hsp16.3, can hence be used as lead compounds to obtain better therapeutics against latent tuberculosis.
    Type: Application
    Filed: May 26, 2004
    Publication date: February 15, 2007
    Applicant: Council of Scientific and Industrial Research (CSIR)
    Inventors: Sujoy Das Gupta, Abhik Saha, Archna Sharma, Siddhartha Roy, Bhabatarak Bhattacharya, Pinakpani Chakrabarti