Abstract: A fixation device for providing rotation stability to a femoral neck fracture. The device includes a bone plate having at least one opening, a compression screw housing extendable through the opening of the bone plate, a compression screw being at least partially disposed within the bore of the housing and selectively moveable through the bore, and a collapsible and expandable anchoring member coupled to the compression screw. The anchoring member is configured to transition between a collapsed condition and an expanded condition upon advancement of the anchoring member from the compression screw housing to rotationally stabilize the compression screw within a femur.

Abstract: A fixation device for providing rotation stability to a femoral neck fracture. The device includes a bone plate having at least one opening, a compression screw housing extendable through the opening of the bone plate, a compression screw being at least partially disposed within the bore of the housing and selectively moveable through the bore, and a collapsible and expandable anchoring member coupled to the compression screw. The anchoring member is configured to transition between a collapsed condition and an expanded condition upon advancement of the anchoring member from the compression screw housing to rotationally stabilize the compression screw within a femur.

Abstract: Methods, systems, and storage media for providing a calibration testing template are disclosed. Exemplary implementations may: provide, at a user interface and using at least one processor associated with a calibration testing template, a customized testing data sheet comprising a plurality of test points; receive, from the test data input cell and using the at least one processor, a test data input associated with an equipment item; receive, from the test data output cell and using the at least one processor, a test data output associated with the equipment item; determine, using the at least one processor and based on the received test data input and test data output, an output error; and determine, using the at least one processor and based on the determined output error, a status result of the equipment item.

Abstract: Certain embodiments of the invention provide a masked single-domain antibody as described herein, as well as methods of use thereof. Certain embodiments of the invention provide a masked CSAN as described herein, as well as methods of use thereof.

Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.

Abstract: The present invention provides biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.

Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.

Abstract: The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities. In particular, the present application is directed to fusion proteins comprising a fragment of human human carbonic anhydrase 2 and a chimeric antigen receptor (CAR). The activity of the destabilizing domain can be regulated by externally administered agents.

Abstract: The present disclosure relates to tunable biocircuit systems for the development of controlled and/or regulated therapeutic systems. In particular, regulatable biocircuits containing destabilizing domains (DD) derived from mutant human cGMP-specific phosphodiesterase type 5 (PDE5) are disclosed. Especially, the present disclosure provides an effector module. Such effector module may include (a) a stimulus response element (SRE), wherein the SRE is a DD, said DD comprising at least one mutation relative to cGMP-specific 3?,5?-cyclic phosphodiesterase (hPDE5; SEQ ID NO: 1) and (b) at least one payload, which is attached, appended or associated with said SRE. The SRE may be responsive to one or more stimuli.

Abstract: The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.

Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.

Abstract: The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.

Abstract: A fixation device for providing rotation stability to a femoral neck fracture. The device includes a bone plate having at least one opening, a compression screw housing extendable through the opening of the bone plate, a compression screw being at least partially disposed within the bore of the housing and selectively moveable through the bore, and a collapsible and expandable anchoring member coupled to the compression screw. The anchoring member is configured to transition between a collapsed condition and an expanded condition upon advancement of the anchoring member from the compression screw housing to rotationally stabilize the compression screw within a femur.

Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.