Patents by Inventor Abimael D. Rodriguez

Abimael D. Rodriguez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plakortinic acids A and B: cytotoxic cycloperoxides with a unique bicyclo[4.2.0]octene unit from sponges of the genera and
    Patent number: 11198678
    Abstract: Plakortinic acids A (2) and B (3), two polyketide endoperoxides having an unprecedented bicyclo[4.2.0]octene unit, were isolated as minor constituents from the sponge-sponge symbiotic association Plakortis halichondrioides-Xestospongia deweerdtae from Puerto Rico, along with the known epiplakinic acid F (1). The molecular structures of 2 and 3 were determined mainly on the basis of NMR spectroscopy. Due to the structural similarities, 2 and 3 are thought to be biosynthetically related to 1. Biological screening for cytotoxic activity against two human tumor cell lines revealed that these novel metabolites are very active at low to sub-micro molar concentration.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: December 14, 2021
    Assignee: University of Puerto Rico
    Inventors: Abimael D. Rodriguez Pierluissi, Carlos Jimenez Romero
  • Natural product-based synthesis of novel anti-infective isothiocyanate- and isoselenocyanate-functionalized amphilectane diterpenes
    Patent number: 10173974
    Abstract: The marine natural product (?)-8,15-diisocyano-11(20)-amphilectene, isolated from the Caribbean sponge Svenzea flava, was used as scaffold to synthesize five new products, all of which were tested against laboratory strains of Plasmodium falciparum and Mycobacterium tuberculosis H37Rv. The scaffold contains two isocyanide units that are amenable to chemical manipulation, enabling them to be elaborated into a small library of sulfur and selenium compounds. The scaffold along with its isothio- and isoselenocyanate analogs has low to sub-micro molar antiplasmodial activity.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: January 8, 2019
    Assignee: University of Puerto Rico
    Inventors: Abimael D. Rodríguez Pierluissi, Karinel Nieves Merced
  • SYNTHESIS OF RING B ABEO-STEROLS AS NOVEL INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS
    Publication number: 20110087037
    Abstract: Novel 3?-hydroxy-?5-steroid analogs possessing a contracted cyclopentane B-ring provide good inhibitory activity against Mycobacterium tuberculosis. The 5(6?7)abeo-sterol nucleus present in compounds of the invention represents a novel scaffold for the development of new antitubercular agents.
    Type: Application
    Filed: October 31, 2008
    Publication date: April 14, 2011
    Applicant: OFFICE OF INTELLECTUAL PROPERTY AND TECHNOLOGY VIC
    Inventors: Abimael D. Rodriguez-Pierluissi, Xiaomei Wei
  • Tobacco cembranoids block the expression of the behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptors
    Patent number: 6489357
    Abstract: The subject invention relates the use of cembranoids to inhibit nicotine addiction at the behavioral level. The subject host is sensitized to nicotine. Cembranoids are then administered to reduce such sensitization.
    Type: Grant
    Filed: October 21, 2000
    Date of Patent: December 3, 2002
    Assignees: University of Puerto Rico, Universidad Central del Caribe Bayamòn
    Inventors: Vesna A. Eterovic, Pedro A. Ferchmin, Richard M. Hann, One R. Pagan, Abimael D. Rodriguez, Osvaldo Rosario
  • Cembranoid inhibitors of nicotinic acetylcholine receptors
    Patent number: 6204289
    Abstract: The present invention relates to the use of cembranoids to inhibit nicotinic acetylcholine receptors.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: March 20, 2001
    Inventors: Vesna A. Eterovic, Abimael D. Rodriguez, Richard M. Hann, Pedro A. Ferchmin, One R. Pagan, Misty J. Eaton