Patents by Inventor Abner L. Notkins

Abner L. Notkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and methods for detection of insulin dependent diabetes
    Patent number: 6391651
    Abstract: The method and compositions of this invention provide an effective and reliable substitute for the currently employed ICA assay for diabetes. By providing a method for detecting autoantibodies to both GAD65 and IA-2 auto-antigens, the method provides a chemical assay which has improved reliability. In addition, these antigens may be employed in therapeutic regimens aimed at achieving immune tolerance and therefore amelioration of the clinical condition.
    Type: Grant
    Filed: August 11, 1995
    Date of Patent: May 21, 2002
    Assignees: The United States of America as represented by the Secretary of the Department of Health & Human Services, University of Florida
    Inventors: Noel K. Maclaren, Abner L. Notkins, Michael S. Lan
  • Human insulinoma-associated cDNA
    Patent number: 6225049
    Abstract: A novel insulinoma-associated, neuroendocrine tumor-associated cDNA sequence is disclosed. The sequence and fragments thereof are useful for the diagnosis and identification of insulinoma and neuroendocrine tumors. The invention relates to a method for identifying a cancer employing the insulinoma-associated nucleic acid, polypeptide and antibody generated thereto.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: May 1, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael S. Lan, Abner L. Notkins
  • Materials and methods for detection and treatment of insulin-dependent diabetes
    Patent number: 5989551
    Abstract: The method and compositions of this invention provide an effective and reliable substitute for the currently employed ICA assay for diabetes. By providing a method for detecting autoantibodies to GAD.sub.65, IA-2 and a previously unidentified antigen termed IA-2.beta. herein, the method provides a chemical assay which has improved reliability. In addition, these antigens may be employed in therapeutic regimens aimed at achieving amelioration of the clinical condition.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: November 23, 1999
    Assignees: The United States of America as represented by the Department of Health and Human Services, The University of Florida
    Inventors: Noel K. Maclaren, Abner L. Notkins, Michael S. Lan, Qing Li