Abstract: The present invention relates to the construction and use of a device to compress biological parts (such as the abdomen), during the performance of interventional procedures (such as percutaneous biopsy), guided by cross sectional imaging procedures (such as computed tomography). The device is composed of a compressive surface with a hole. The compressive surface is constructed as part of a downward protruding member and lateral flanges or a rim, which can be attached, for example, to an abdomen, by means of a strap mechanism. An optional back plate can be used, such that a strap mechanism compresses the body part between the back plate and compression plate, or the compression plate alone can be place. The device can remain in place during cross sectional imaging, provided effective compression of the animal or human body part, yet access for percutaneous intervention is maintained by means of the hole in the compression surface.