Abstract: The present invention concerns a polyphenol extract from cinnamon bark in the form of nanoparticles and its use as an antiviral agent.

Abstract: Embodiments of stable topical compositions for administering fenoldopam (compound (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed for immediate or continued slow release administration, over prolonged periods of time with safe minimal systemic exposure of fenoldopam (reducing the risk for lowering blood pressure). The compositions include those compositions that increase the stability and skin absorption of the drug, particularly anhydrous semi-solid compositions and creams. This is accomplished by incorporating fenoldopam in soluble or dispersed form into semi-solid compositions like ointments or anhydrous gels that are not irritative. Embodiments of methods for using the topical compositions in the treatment of dermatological disorders including psoriasis, alopecia atopic dermatitis and vitiligo are disclosed.

Abstract: A tissue displacement/separation device includes a seamless bladder constructed of a biodegradable polymer. The bladder is expandable from a collapsed or rolled state for insertion into a body between a first and second tissue to an expanded state for separating the first and second tissue.

Abstract: The invention provides devices, formulations, and methods for systemic delivery of agents in the oral and buccal cavity and the gastrointestinal system, including immediate and prolonged drug delivery. The invention is particularly applicable to poorly water-soluble agents and drugs.

Abstract: The invention provides a particle comprising a lipid core and surface-decorated (nano)particles of at least one stabilizing material, for delivery of active agents.

Abstract: The invention provides an isolated material, or a phenolate form of at least one phenol- containing active material, wherein the isolated material comprises one or more phenolate species and a counter ion (a cation) in the form of a metal salt, a phosphonium or an ammonium.

Abstract: Compositions comprising nanoparticles are described herein. At least a portion of the nanoparticles comprises a lipid and/or polymer which is water-insoluble, and an agent incorporated in the lipid and/or polymer. The nanoparticles are optionally associated with a surface of water-soluble particles which comprise a water-soluble compound. The polymer is optionally a polyanhydride. Further described herein are processes for preparing such compositions, comprising contacting a solution comprising the lipid and/or polymer dissolved in a non-aqueous solvent with an anti-solvent (in which the lipid and/or polymer and agent are insoluble) which is miscible with the non-aqueous solvent. Further described herein are uses of the compositions for nasal administration, and devices configured for nasal administration of the composition upon atomization.

Abstract: Embodiments of stable topical compositions for administering fenoldopam (compound (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed for immediate or continued slow release administration, over prolonged periods of time with safe minimal systemic exposure of fenoldopam (reducing the risk for lowering blood pressure). The compositions include those compositions that increase the stability and skin absorption of the drug, particularly anhydrous semi-solid compositions and creams. This is accomplished by incorporating fenoldopam in soluble or dispersed form into semi-solid compositions like ointments or anhydrous gels that are not irritative. Embodiments of methods for using the topical compositions in the treatment of dermatological disorders including psoriasis, alopecia atopic dermatitis and vitiligo are disclosed.

Abstract: A manufacturing assembly and method produce a wire mesh including a plurality of longitudinal members and a monolithic transverse member secured to the plurality of longitudinal members. The monolithic transverse member includes a plurality of transverse portions that define a first cross-sectional shape, and further includes a plurality of longitudinal portions that define a second cross-sectional shape different than the first cross-sectional shape.

Abstract: A rotary slitting blade for fabricating expanded metal products includes opposed end surfaces and an outer circumferential surface extending from one of the end surfaces to the other of the end surfaces. A plurality of notches are formed in each of the end surfaces. The notches include curved surfaces having convex curvatures that smoothly transition into one of the end surfaces and/or the outer circumferential surface. The rotary slitting blade improves the quality of a resulting expanded metal product by reducing or eliminating tears, cracks, and fractures in the expanded metal product.

Abstract: A system and method for an index-based smart scan for a cloud-computing provider network is provided. The system includes a memory having computer-readable instructions stored therein and a snapshot repository configured to store a plurality of snapshots of a plurality of block storage volumes. Each of the plurality of block storage volumes is configured to perform volume based block storage operations for the cloud-computing provider network. The system further includes a processor communicatively coupled to the snapshot repository. The processor is configured to access contents of each of the plurality of snapshots. Each of the plurality of snapshots includes a point-in-time capture of the respective block storage volume. In addition, the processor is configured to perform a full scan of each of the plurality of snapshots to identify one or more files of the respective block storage volume. The processor is further configured to generate a folder index table for each of the files based upon the scan.

Abstract: An adjustable protective face covering having a first end having one or more openings spaced apart there along and a second opposing end having one or more openings spaced apart there along. A length extends therebetween for covering a mouth and nose of a wearer, and the face covering is a single use face covering that is a constructed from a unitary sheet comprised of surgical wrap, polypropylene, Spunbond Meltblown Spunbond (SMS), or cotton. The single component mask can be cut from sheets of substrate using various techniques including laser cutting, die cutting, or other machinery typically of use in clothing manufacture.

Abstract: A manufacturing assembly and method produce a wire mesh including a plurality of longitudinal members and a monolithic transverse member secured to the plurality of longitudinal members. The monolithic transverse member includes a plurality of transverse portions that define a first cross-sectional shape, and further includes a plurality of longitudinal portions that define a second cross-sectional shape different than the first cross-sectional shape.

Abstract: Compositions comprising nanoparticles are described herein. At least a portion of the nanoparticles comprises a lipid and/or polymer which is water-insoluble, and an agent incorporated in the lipid and/or polymer. The nanoparticles are optionally associated with a surface of water-soluble particles which comprise a water-soluble compound. The polymer is optionally a polyanhydride. Further described herein are processes for preparing such compositions, comprising contacting a solution comprising the lipid and/or polymer dissolved in a non-aqueous solvent with an anti-solvent (in which the lipid and/or polymer and agent are insoluble) which is miscible with the non-aqueous solvent. Further described herein are uses of the compositions for nasal administration, and devices configured for nasal administration of the composition upon atomization.

Abstract: A stud such as a light-weight metal stud can include a first elongated channel member and a second elongated channel member coupled to the first elongated channel member by a wire matrix, where ends of the wire matrix are located at ends of the first and second channel members. A pitch of the wire matrix can vary over the length of the stud. Two or more such studs can have different lengths where a difference in the lengths is not a multiple of the pitch.

Abstract: A rotary slitting blade for fabricating expanded metal products includes opposed end surfaces and an outer circumferential surface extending from one of the end surfaces to the other of the end surfaces. A plurality of notches are formed in each of the end surfaces. The notches include curved surfaces having convex curvatures that smoothly transition into one of the end surfaces and/or the outer circumferential surface. The rotary slitting blade improves the quality of a resulting expanded metal product by reducing or eliminating tears, cracks, and fractures in the expanded metal product.

Abstract: A system and method for an index-based smart scan for a cloud-computing provider network is provided. The system includes a memory having computer-readable instructions stored therein and a snapshot repository configured to store a plurality of snapshots of a plurality of block storage volumes. Each of the plurality of block storage volumes is configured to perform volume based block storage operations for the cloud-computing provider network. The system further includes a processor communicatively coupled to the snapshot repository. The processor is configured to access contents of each of the plurality of snapshots. Each of the plurality of snapshots includes a point-in-time capture of the respective block storage volume. In addition, the processor is configured to perform a full scan of each of the plurality of snapshots to identify one or more files of the respective block storage volume. The processor is further configured to generate a folder index table for each of the files based upon the scan.

Abstract: The present disclosure relates generally to improving the management and provisoning of configurable computing resources. Certain techniques are disclosed herein for managing and provisoning the configurable computing resources based on resource policies. One of the techniques includes receiving a resource submission from a user. The resource submission identifies a contributable resource. The technique may also include identifying a contribution policy for the resource submission, and sending, based on the identified contribution policy, one or more resource types of requestable resources to a client computing system associated with the user. The technique may also include receiving, from the client computing system, information indicating a selection by the user of a resource type of the one or more resource types of the requestable resources.