Patents by Inventor Abraham Patchornik
Abraham Patchornik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150283168Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.Type: ApplicationFiled: April 30, 2015Publication date: October 8, 2015Inventors: Noah BEN-SHALOM, Zvi NEVO, Abraham PATCHORNIK, Dror ROBINSON
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Patent number: 9034348Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.Type: GrantFiled: March 14, 2013Date of Patent: May 19, 2015Assignee: Chi2Gel Ltd.Inventors: Noah Ben-Shalom, Zvi Nevo, Abraham Patchornik, Dror Robinson
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Publication number: 20130244972Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.Type: ApplicationFiled: March 14, 2013Publication date: September 19, 2013Applicant: MOR RESEARCH APPLICATIONS LTD.Inventors: Noah Ben-Shalom, Zvi Nevo, Abraham Patchornik, Dror Robinson
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Publication number: 20120189704Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.Type: ApplicationFiled: April 3, 2012Publication date: July 26, 2012Applicant: CHI2GEL LTD.Inventors: Noah Ben-Shalom, Zvi Nevo, Abraham Patchornik, Dror Robinson
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Patent number: 8153612Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.Type: GrantFiled: June 11, 2008Date of Patent: April 10, 2012Assignee: Chi2Gel Ltd.Inventors: Noah Ben-Shalom, Zvi Nevo, Abraham Patchornik, Dror Robinson
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Publication number: 20090004276Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.Type: ApplicationFiled: June 11, 2008Publication date: January 1, 2009Applicant: Mor Research Applications Ltd.Inventors: Noah Ben-Shalom, Zvi Nevo, Abraham Patchornik, Dror Robinson
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Patent number: 5283196Abstract: Amine-acryloyl and -methacryloyl derivatives and 1,6-heptadiene-4-ol can be used to provide crosslinked polyacrylamide gels which are useful in protein and nucleic acid separation and detection. The gels crosslinked with the compounds of the present invention exhibit much less background silver staining than previously known acrylamide gels.Type: GrantFiled: November 7, 1991Date of Patent: February 1, 1994Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Denis F. Hochstrasser, Carl R. Merrill, Abraham Patchornik
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Patent number: 4698208Abstract: An automated apparatus for conducting a broad range of organic synthesis reactions includes a first column carring a polymeric support, a second column carrying a second polymer support, and conduits connecting the two columns and permitting the circulation of fluids therebetween. In operation each polymeric support carries a different reactive species and a liquid medium containing a specifically selected intermediate reactant, in a solvent, is circulated between the columns in order to remove the reactive species from the first support by reaction with the intermediate, and to permit the reactive species thus removed to react with the reactive second support, at the same time regenerating the original intermediate reactant. Sensors are placed at the entrance and exit of the second column carrying the second polymeric support. The sensors are capable of sensing the relative presence of the intermediate reactant.Type: GrantFiled: June 10, 1985Date of Patent: October 6, 1987Assignee: Yeda Research and Development Co., Ltd.Inventors: Abraham Patchornik, Yechiel Shai, Shimeon Pass
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Patent number: 4552922Abstract: A broad range of organic synthesis reactions can be conducted by means of a process using two polymeric supports, each carrying different reactive species. A liquid medium containing a specifically selected intermediate reactant, in a solvent, is circulated between the supports in order to remove the reactive species from the first support by reaction with the intermediate, and permit the reactive species thus removed to react with the reactive species of the second support, at the same time regenerating the original intermediate reactant. This circulation continues until the second support is suitably loaded with the reaction product, at which time the circulation is stopped and the reaction products separated and recovered. The process may be carried out in an automated apparatus in which sensors are placed at the entrance and exit of the column carrying the second polymeric support. The sensors are capable of sensing the relative presence of the intermediate reactant.Type: GrantFiled: June 24, 1983Date of Patent: November 12, 1985Assignee: Yeda Research & Development Co. Ltd.Inventors: Abraham Patchornik, Yechiel Shai, Shimeon Pass
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Patent number: 4317887Abstract: Novel polyfunctional compounds and polymers are disclosed of the general formula ##STR1## wherein Q designates -X' or -X-.epsilon.-R; where X' designates ##STR2## where .alpha. is --OH, or --SH;.beta. is --OH, --SH, --NH.sub.2, --NO.sub.2, --CO--R.sub.2, --R.sub.2 C.dbd.N--OH, --COOH, -hal, alkyl, aryl, or aralkyl; halogen being chlorine or bromine;.gamma. is a non-interfering substituent;where .beta. and .gamma. may form together a hydrocarbyl ring system;where .delta. is --(CH.sub.2).sub.n -- or --SO.sub.2 --;where X is --O--, --S--, --NH--, --N.sup.+ R.sub.2 R.sub.3 Cl.sup.- or --P--;where.epsilon. is --(CH.sub.2).sub.n --, --SO.sub.2 --, --NH-- or --CH.sub.2 (O-CH.sub.2 --CH.sub.2).sub.n --; ##STR3## wherein the upwardly directed bonds are connected to the R polymer molecule and the downwardly directed bonds are connected to .delta. groups;n is an integer of from 1 to 15 or zero;R is a polymeric backbone, alkyl or aralkyl; andR.sub.2, R.sub.3 and R.sub.Type: GrantFiled: August 10, 1979Date of Patent: March 2, 1982Assignee: Yeda Research and Development Co. Ltd.Inventors: Abraham Warshawsky, Rami Kalir, Abraham Patchornik
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Patent number: 4244885Abstract: .alpha.-Substituted-3-(halomethyl)-4-hydroxybenzeneacetic acids, prepared by the halomethylation of .alpha.-substituted-4-hydroxybenzeneacetic acids are new and useful as starting materials for the preparation of cephalosporin and penicillin derivatives.Type: GrantFiled: December 8, 1977Date of Patent: January 13, 1981Assignee: Yeda Research and Development Co. Ltd.Inventors: Abraham Nudelman, Abraham Patchornik
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Patent number: 4236002Abstract: New 7-[4-hydroxy-3-(substituted methyl)phenyl]acetamido cephalosporin derivatives are prepared which are useful as antibiotics.Type: GrantFiled: December 23, 1977Date of Patent: November 25, 1980Assignee: Yeda Research & Development Co., Ltd.Inventors: Abraham Nudelman, Abraham Patchornik
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Patent number: 4229363Abstract: New 4-hydroxy-3-(substitutedmethyl)benzeneacetic acids have been prepared which are useful as starting materials in the preparation of cephalosporin and penicillin derivatives.Type: GrantFiled: September 7, 1978Date of Patent: October 21, 1980Assignee: Yeda Research and Development Co., Ltd.Inventors: Abraham Nudelman, Abraham Patchornik
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Patent number: 4229574Abstract: New indole derivatives of cephalosporin compounds have been prepared which are useful as antibiotics.Type: GrantFiled: August 23, 1979Date of Patent: October 21, 1980Assignee: Yeda Research and Development Co., Ltd.Inventors: Abraham Nudelman, Abraham Patchornik
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Patent number: 4226806Abstract: Novel cephalosporin compounds of the following formula are useful as antibiotic agents: ##STR1##Type: GrantFiled: January 8, 1979Date of Patent: October 7, 1980Assignee: Yeda Research and Development Co. Ltd.Inventors: Fortuna Haviv, Abraham Patchornik
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Patent number: 4200747Abstract: New indole derivatives of cephalosporin compounds have been prepared which are useful as antibiotics.Type: GrantFiled: October 2, 1978Date of Patent: April 29, 1980Assignee: Yeda Research and Development Co. Ltd.Inventors: Abraham Nudelman, Abraham Patchornik
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Patent number: 4197240Abstract: New 7-[4-hydroxy-3-(substitutedmethyl)phenyl]acetamido penicillin derivatives are prepared which are useful as antibiotics.Type: GrantFiled: December 23, 1977Date of Patent: April 8, 1980Assignee: Yeda Research and Development Co. Ltd.Inventors: Abraham Nudelman, Abraham Patchornik
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Patent number: 4180660Abstract: New cephalosporin derivatives containing a formyl substituted pyrrole group and the processes for preparing same are described.Type: GrantFiled: September 1, 1978Date of Patent: December 25, 1979Assignee: Yeda Research and Development Co. Ltd.Inventors: Abraham Nudelman, Abraham Patchornik
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Patent number: 4180661Abstract: Novel cephalosporin derivatives of the following formula are useful as antibacterial agents: ##STR1##Type: GrantFiled: July 17, 1978Date of Patent: December 25, 1979Assignee: Yeda Research and Development Co. Ltd.Inventors: Fortuna Haviv, Abraham Nudelman, Abraham Patchornik
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Patent number: 4172942Abstract: Novel compounds of the formula ##STR1## are useful as antibiotics.Type: GrantFiled: July 17, 1978Date of Patent: October 30, 1979Assignee: Yeda Research and Development Co. Ltd.Inventors: Abraham Nudelman, Abraham Patchornik