Patent number: 7491729
Abstract: 3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof. The invention relates to 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, if appropriate, the fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2, —NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2 and —NH(R6). The preparation and use of these derivatives, especially for therapeutic purposes, e.g.
Type:
Grant
Filed:
December 17, 2003
Date of Patent:
February 17, 2009
Assignee:
Abbott GmbH & Co. KG
Inventors:
Margaretha Bakker, Wilfried Hornberger, Andreas Kling, Udo Lange, Helmut Mack, Achim Moeller, Reinhold Mueller, Kurt Schellhaas, Martin Schmidt, Gerd Steiner, Karsten Wicke
Patent number: 7276500
Abstract: An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: A —(CH2)p—R1, where R1 can be pyrrolidine [sic], morpholine [sic], piperidine [sic], —NR5R6 and ?and R5, R6 and R7 can, independently of one another, be hydrogen, C1-C4-alkyl, CH2Ph, Ph, CH2CH2Ph, it also being possible for the phenyl rings to be substituted by R6, and p can be 1 and 2, and B can be phenyl [sic], pyridyl [sic], pyrimidyl [sic] and pyridazyl [sic], it also being possible for the rings to be substituted by up to 2 R8 radicals, and D can be a bond, —(CH2)m—, —CH?CH—, —C?C—, and R2 is chlorine, bromine, fluorine, C1-C6-alkyl, NHCO—C1-C4-alkyl, NHSO2—C1-C4-alkyl, NO2, —O—C1-C4-alkyl and NH2, and R3 is —C1-C6-alkyl, branched or unbranched, and which may also carry a phenyl ring, indolyl ring or cyclohexyl ring which is in turn substituted by by [sic] a maximum of two R8 radicals
Type:
Grant
Filed:
October 20, 2003
Date of Patent:
October 2, 2007
Assignee:
Abbott GmbH & Co. KG
Inventors:
Wilfried Lubisch, Achim Möller, Hans-Jörg Treiber, Monika Knopp
Publication number: 20060142317
Abstract: The invention relates to 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, if appropriate, the fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2, —NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2 and —NH(R6). The preparation and use of these derivatives, especially for therapeutic purposes, e.g. for the treatment of depressions, are likewise described.
Type:
Application
Filed:
December 17, 2003
Publication date:
June 29, 2006
Inventors:
Margaretha Bakker, Wilfried Hornberger, Andreas Kling, Udo Lange, Helmut Mack, Achim Moeller, Reinhold Mueller, Kurt Schelhaas, Martin Schmidt, Gerd Steiner, Karsten Wicke
Patent number: 6753327
Abstract: An amide of the formula I
and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings:
A —(CH2)p—R1, where R1 can be pyrrolidine, morpholine, piperidine, —NR5R6 and
and R5, R6 and R7 can, independently of one another, be hydrogen, C1-C4-alkyl, CH2Ph, Ph, CH2CH2Ph, it also being possible for the phenyl rings to be substituted by R6, and p can be 1 and 2, and
B can be phenyl, pyridyl, pyrimidyl and pyridazyl, it also being possible for the rings to be substituted by up to 2 R8 radicals, and
D can be a bond, —(CH2)m, —CH═CH—, —C≡C—, and
Y is phenyl, pyridine, pyrimidine and pyrazine and
n is a number 0, 1 or 2, and
m,q are, independently of one another, a number 0, 1, 2, 3 or 4.
Type:
Grant
Filed:
October 11, 2000
Date of Patent:
June 22, 2004
Assignee:
Abbott GmbH & Co. KG
Inventors:
Wilfried Lubisch, Achim Möller, Hans-Jörg Treiber, Monika Knopp