Patents by Inventor Ada Yonath

Ada Yonath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM S. AUREUS
    Publication number: 20200339635
    Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.
    Type: Application
    Filed: July 7, 2020
    Publication date: October 29, 2020
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ada YONATH, Zohar EYAL, Donna MATZOV, Haim ROZENBERG, Ella ZIMMERMAN, Anat BASHAN
  • Crystal structure of the large ribosomal subunit from
    Patent number: 10723770
    Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.
    Type: Grant
    Filed: December 24, 2019
    Date of Patent: July 28, 2020
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ada Yonath, Zohar Eyal, Donna Matzov, Haim Rozenberg, Ella Zimmerman, Anat Bashan
  • CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM S. AUREUS
    Publication number: 20200131232
    Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.
    Type: Application
    Filed: December 24, 2019
    Publication date: April 30, 2020
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ada YONATH, Zohar EYAL, Donna MATZOV, Haim ROZENBERG, Ella ZIMMERMAN, Anat BASHAN
  • Crystal structure of the large ribosomal subunit from
    Patent number: 10556934
    Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: February 11, 2020
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ada Yonath, Zohar Eyal, Donna Matzov, Haim Rozenberg, Ella Zimmerman, Anat Bashan
  • CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM S. AUREUS
    Publication number: 20180009853
    Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.
    Type: Application
    Filed: January 26, 2016
    Publication date: January 11, 2018
    Inventors: Ada YONATH, Zohar EYAL, Donna MATZOV, Haim ROZENBERG, Ella ZIMMERMAN, Anat BASHAN
  • SYNERGISTIC ANTIBIOTIC COMBINATIONS AND DERIVATIVES
    Publication number: 20120316106
    Abstract: Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions that include these improved analogs and synergistic combinations, along with methods for their production and use. The synergistic combinations target neighboring sites in the ribosome demonstrating the importance of the corresponding ribosomal sites for development of clinically-relevant synergistic antibiotics.
    Type: Application
    Filed: December 29, 2010
    Publication date: December 13, 2012
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Ada Yonath, Chen Davidovich, Ella Zimmerman, Anat Bashan, Tamar Auerbach, Matthew Belousoff, Liqun Xiong, Dorota Klepacki, Alexander S. Mankin
  • Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals
    Publication number: 20090081697
    Abstract: Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, coordinates defining the 3D atomic structure thereof and methods of utilizing such coordinates for rational design or identification of antibiotics or large ribosomal subunits having desired characteristics are disclosed.
    Type: Application
    Filed: December 2, 2008
    Publication date: March 26, 2009
    Applicants: Yeda Research and Development Co. Ltd., Max Planck Society
    Inventors: Ada Yonath, Francois Franceschi, Joerg Harm, Frank Schluenzen, Raz Zarivach, Anat Bashan, Renate Albrecht
  • Methods of growing crystals of free, antibiotic-complexed, and substrate-complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals
    Publication number: 20040265984
    Abstract: Methods of growing crystals of free, antibiotic complexed, or ribosomal substrate complexed large ribosomal subunits, coordinates defining the three-dimensional atomic structure thereof and methods of utilizing such coordinates for rational design or identification of antibiotics or large ribosomal subunits having desired characteristics are disclosed.
    Type: Application
    Filed: August 25, 2004
    Publication date: December 30, 2004
    Inventors: Ada Yonath, Anat Bashan, Raz Zarivach, Francois Francheschi, Frank Schluenzen, Joerg Harms, Renate Albrecht, Rita Berisio
  • Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals
    Publication number: 20030027315
    Abstract: Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, coordinates defining the 3D atomic structure thereof and methods of utilizing such coordinates for rational design or identification of antibiotics or large ribosomal subunits having desired characteristics are disclosed.
    Type: Application
    Filed: March 29, 2002
    Publication date: February 6, 2003
    Inventors: Ada Yonath, Francois Franceschi, Joerg Harms, Frank Schluenzen, Raz Zarivach, Anat Bashan, Renate Albrecht