Abstract: Systems and methods for use in mapping an interior space of a product storage facility include at least one sensor that captures distance measurement data with respect to an interior space of the product storage facility. A computing device obtains a first image representing a 2-dimensional map of the interior space of the product storage facility and processes this image to define a boundary of the interior space of the product storage facility and detect individual structures located within the interior space of the product storage facility. Then, the computing device defines separate department areas, assigns a department label to each of the separate department areas, and converts the 2-dimensional map representing the detected structures and the defined separate department areas and the department labels assigned to the separate department areas into a second image representing a 3-dimensional map of the interior space of the product storage facility.

Abstract: Some embodiments provide systems comprising: a machine learning model database; a deblur system configured to receive at least a portion of an image comprising a presumed location label captured by the image capture device, and apply at least a deblurring machine learning framework to generate a deblurred label image comprising the presumed location label; a rectification system configured to apply an machine learning transform algorithm to the deblurred label image to generate a rectified label image; an optical character recognition (OCR) system configured to apply a recognition machine learning model to the rectified label image to estimate text; and a location estimation system configured to estimate a location of the presumed location label as a function of the estimated text of the presumed location label relative to known text on known location labels position at respective different known locations within the product storage facility.

Abstract: A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.

Abstract: An applicator used to apply microneedle arrays to a mammal. An applicator capable of sensing a controlled distance from a skin surface and propelling a microneedle array across this distance and into the skin surface is disclosed. A method of applying a microneedle array to a skin surface by placing the microneedle array a predetermined distance away from the skin surface and propelling the microneedle array into the skin surface is disclosed.

Abstract: A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.