Abstract: The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.

Abstract: A retaining assembly for coupling a fluid end component to a fluid end casing. The retaining assembly includes a pair for clamp members, each of which has a pair of rails that define a wedge-shaped groove therebetween. The groove applying an increasing amount of pre-load force or tension to a flange of the fluid end components and a flange of the fluid end casing to drive them together. The amount of pre-load tension applied can vary and can be determined by the user and amount of tightening of the clamp members.

Abstract: A cradle plate for high pressure reciprocating pumps is installable within a cradle disposed between a power end of a high pressure reciprocating pump and a fluid end of the high pressure reciprocating pump. The cradle plate has a main body that extends from a front surface to a back surface and a first set of openings that extend through the main body. The first set of openings are configured to receive a set of elongate couplers that position the cradle plate within the cradle in a position that secures a fluid end component against a casing of the fluid end, against a seal of the fluid end, or against both the casing and the seal.

Abstract: A system and method of identifying objects is provided. In one aspect, the system and method includes a hand-held device with a display, camera and processor. As the camera captures images and displays them on the display, the processor compares the information retrieved in connection with one image with information retrieved in connection with subsequent images. The processor uses the result of such comparison to determine the object that is likely to be of greatest interest to the user. The display simultaneously displays the images the images as they are captured, the location of the object in an image, and information retrieved for the object.

Abstract: A sealing assembly for a fluid end of a reciprocating pump is installable within a segment of a casing of the fluid end and is arranged to form a seal with the segment. The sealing assembly includes a closure element and a seal element. The closure element has a sealing portion with a lateral surface that faces an interior wall of the segment of the fluid end. The seal element is sized to be installed around the closure element and includes a seal and one or more seal carriers. The seal is configured to form a seal between the lateral surface of the closure element and the interior wall of the segment. The one or more seal carriers are configured to position the seal with respect to the closure element.

Abstract: This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a deformable reservoir being at least partially defined by rigid plastically-deformable web. An actuator can press against said rigid plastically-deformable web to plastically deform said web. In some cases, a controller is adapted to receive a cartridge including a deformable reservoir and control the pressing of an actuator against a rigid plastically-deformable web to deliver fluid from the deformable reservoir.

Abstract: This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a deformable reservoir being at least partially defined by rigid plastically-deformable web. An actuator can press against said rigid plastically-deformable web to plastically deform said web. In some cases, a controller is adapted to receive a cartridge including a deformable reservoir and control the pressing of an actuator against a rigid plastically-deformable web to deliver fluid from the deformable reservoir.

Abstract: A method of repeatedly indicating to a user of an appliance that a water filter unit operably connected to the appliance has passed its useful life and a filter unit configure for use in connection with the method where the filter unit includes a fluid flow impeding system within a housing of the filter unit; engaging the filter unit with the appliance; measuring the volume of water treated by the filter unit; activating a fluid flow impeding system contained within the housing of the filter unit; and repeatedly indicating to a user that the maximum volume of water the filter unit has been designed to treat has been surpassed and the filter unit should be replaced by repeatedly delivering a normal flow rate of water from the dispenser of the appliance and thereafter slowing the flow of water from the dispenser of the appliance.

Abstract: This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a deformable reservoir being at least partially defined by rigid plastically-deformable web. An actuator can press against said rigid plastically-deformable web to plastically deform said web. In some cases, a controller is adapted to receive a cartridge including a deformable reservoir and control the pressing of an actuator against a rigid plastically-deformable web to deliver fluid from the deformable reservoir.

Abstract: A mobile wireless device has a device identifier, is located in a meeting venue, and communicates with a server through one or more wireless access points associated with the meeting venue. The device receives, from one of the access points, access point information that identifies the access point, and sends information including the device identifier to the access point.

Abstract: A system includes a remote controller and an infusion pump. The infusion pump includes an RF telemetry portion configured to receive an RF data signal from the remote controller. A processing portion is configured to process the RF data signal received by the RF telemetry portion. A dispensing apparatus, responsive to the processing portion of the medical device, dispenses medicament in accordance with the RF data signal. The dispensing apparatus includes a fill sensor for providing an initialization signal to the processing portion of the medical device upon the dispensing apparatus being filled with at least a defined volume of medicament.

Abstract: A system for delivering a fluid to a patient includes a remote controller and an infusion pump. The infusion pump includes a dispenser for dispensing the fluid. An RF telemetry portion is configured to receive an RF data signal from the remote controller. A main processing portion is configured to process the RF data signal received by the RF telemetry portion, and control the dispenser in accordance with the RF data signal received by the RF telemetry portion. An interlock processing portion is configured to process the RF data signal received by the RF telemetry portion, and control the dispenser in accordance with the RF data signal received by the RF telemetry portion. The RF telemetry portion and at least one of the processing portions are incorporated into a single microchip.

Abstract: A system for delivering a fluid to a patient includes a remote controller and an infusion pump. The infusion pump includes a dispenser for dispensing the fluid. An RF telemetry portion is configured to receive an RF data signal, from the remote controller, that is broadcast in a non-restricted frequency band. A processing portion is configured to process the RF data signal received by the RF telemetry portion, and control the dispenser in accordance with the RF data signal received by the RF telemetry portion.

Abstract: A system for delivering a fluid to a patient includes a remote controller and an infusion pump. The infusion pump includes a dispenser for dispensing the fluid. An operationally-independent RF telemetry portion is configured to receive an RF data signal from the remote controller. An operationally-independent processing portion is configured to process the RF data signal received by the operationally-independent RF telemetry portion, and control the dispenser in accordance with the RF data signal received by the operationally-independent RF telemetry portion.