Patents by Inventor Adam Golebiowski

Adam Golebiowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20230348516
    Abstract: This invention is related to novel inhibitors of chitinase-like protein YKL-40 and their therapeutic applications. Such YKL-40 inhibitors are of use as therapeutic agents for the treatment a variety of diseases and disorders, including cancers, inflammation, and pulmonary diseases.
    Type: Application
    Filed: April 28, 2023
    Publication date: November 2, 2023
    Inventors: Wojciech Czestkowski, Marzena Mazur, Przemyslaw Wanat, Gleb Andryianau, Piotr Niedziejko, Michal Kowalski, Mariusz Marek Gruza, Kamil Lisiecki, Piotr Pomaransk, Damian Kusmirek, Diana Papiernik, Katarzyna Drzewicka, Katarzyna Piwowar, Katarzyna Krysztofiak, Jacek Olczak, Adam Golebiowski, Lukasz Krzeminski, Agnieszka Bartoszewicz
  • YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20230278996
    Abstract: Disclosed are novel assays for screening active compounds interfering with interaction between chitinase-like protein YKL-40 and chitin oligomers, as well as interfering with interaction between chitinase-like protein YKL-40 and heparan sulfate. Moreover, disclosed are novel active compounds identified by these assays as inhibitors of chitinase-like protein YKL-40, their therapeutic applications, and their use in biosensors measuring the level of chitinase-like protein YKL-40 in biological samples.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 7, 2023
    Inventors: Lukasz Krzeminski, Wojciech Czestkowski, Marzena Mazur, Gleb Andryianau, Sylwia Olejniczak, Michal Czeslaw Piotrowicz, Robert Koralewski, Elzbieta Pluta, Krzysztof Matyszewski, Michal Kowalski, Barbara Dymek, Rafal Koziel, Jacek Olczak, Adam Golebiowski, Agnieszka Bartoszewicz, Katarzyna Krysztofiak
  • DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230219973
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.
    Type: Application
    Filed: December 22, 2022
    Publication date: July 13, 2023
    Inventors: Jacek CHRZANOWSKI, Julita NOWICKA, Lukasz JOACHIMIAK, Robert KORALEWSKI, Sylwia OLEJNICZAK, Marzena MAZUR, BartlomieJ BOREK, Anna GZIK, Krzysztof MATYSZEWSKI, Sylwia CIASTEK-ISKRZYCKA, Piotr NIEDZIEJKO, Angelika MUCHOWICZ, Zbigniew ZASLONA, Roman BLASZCZYK, Jacek OLCZAK, Adam GOLEBIOWSKI
  • Substituted amino triazoles useful as chitinase inhibitors
    Patent number: 11638707
    Abstract: Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: May 2, 2023
    Assignee: Molecure S.A.
    Inventors: Marzena Mazur, Gleb Andryianau, Lukasz Joachimiak, Wojciech Czestkowski, Michal Kowalski, Piotr Niedziejko, Sylwia Olejniczak, Krzysztof Matyszewski, Robert Koralewski, Jacek Olczak, Adam Golebiowski, Agnieszka Bartoszewicz
  • ARGINASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20220204530
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of arginase 1 and arginase 2 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 30, 2022
    Inventors: Anna Gzik, Jacek Chrzanowski, Bartlomiej Borek, Roman Blaszczyk, Jacek Olczak, Adam Golebiowski, Marcin Mikolaj Grzybowski, Paulina Pomper
  • Arginase Inhibitors and Their Therapeutic Applications
    Publication number: 20210260019
    Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Inventors: Roman Blaszczyk, Joanna Brzezinska, Anna Gzik, Adam Golebiowski, Julita Nowicka, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Krzysztof Matyszewski, Jacek Olczak
  • Arginase inhibitors and their therapeutic applications
    Patent number: 10912755
    Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: February 9, 2021
    Assignee: OncoArendi Therapeutics S.A.
    Inventors: Roman Blaszczyk, Joanna Brzezinska, Anna Gzik, Adam A. Golebiowski, Julita Nowicka, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Krzysztof Matyszewski, Jacek Olczak
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS CHITINASE INHIBITORS
    Publication number: 20210015822
    Abstract: Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Application
    Filed: July 15, 2020
    Publication date: January 21, 2021
    Inventors: Marzena Mazur, Gleb Andryianau, Lukasz Joachimiak, Wojciech Czestkowski, Michal L. Kowalski, Piotr Niedziejko, Sylwia Olejniczak, Krzysztof Matyszewski, Robert Koralewski, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz
  • Dipeptide piperidine derivatives
    Patent number: 10851099
    Abstract: The disclosure relates to pharmaceutical compositions, to methods of preparing such compositions, and to methods for using such compositions for treating or preventing a disease or condition associated with arginase activity.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: December 1, 2020
    Assignee: OncoArendi Therapeutics S.A.
    Inventors: Roman Blaszczyk, Anna Gzik, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Julita Nowicka, Jacek Chrzanowski, Joanna Brzezinska, Adam Golebiowski, Jacek Olczak, Marcin Mikolaj Grzybowski, Jolanta Peczkowicz-Szyszka
  • Inhibitors of arginase and their therapeutic applications
    Patent number: 10538537
    Abstract: Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: January 21, 2020
    Assignee: Mars, Incorporated
    Inventors: Michael Van Zandt, Adam Golebiowski, Min K. Ji, Darren Whitehouse, Todd Ryder, Raymond P. Beckett
  • Substituted amino triazoles useful as human chitinase inhibitors
    Patent number: 10538508
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: January 21, 2020
    Assignee: OncoArendi Therapeutics S.A.
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal L. Kowalski
  • Arginase Inhibitors and Their Therapeutic Applications
    Publication number: 20190365701
    Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
    Type: Application
    Filed: August 14, 2019
    Publication date: December 5, 2019
    Inventors: Roman Blaszczyk, Joanna Brzezinska, Anna Gzik, Adam A. Golebiowski, Julita Nowicka, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS
    Publication number: 20190345137
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Application
    Filed: February 15, 2019
    Publication date: November 14, 2019
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal L. Kowalski
  • DIPEPTIDE PIPERIDINE DERIVATIVES
    Publication number: 20190300525
    Abstract: The disclosure relates to pharmaceutical compositions, to methods of preparing such compositions, and to methods for using such compositions for treating or preventing a disease or condition associated with arginase activity.
    Type: Application
    Filed: March 29, 2019
    Publication date: October 3, 2019
    Inventors: Roman Blaszczyk, Anna Gzik, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Julita Nowicka, Jacek Chrzanowski, Joanna Brzezinska, Adam Golebiowski, Jacek Olczak, Marcin Mikolaj Grzybowski, Jolanta Peczkowicz-Szyszka
  • Arginase inhibitors and their therapeutic applications
    Patent number: 10391077
    Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: August 27, 2019
    Assignee: OncoArendi Therapeutics S.A.
    Inventors: Roman Blaszczyk, Joanna Brzezińska, Anna Gzik, Adam Golebiowski, Julita Nowicka, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Krzysztof Matyszewski, Jacek Olczak
  • Arginase inhibitors and their therapeutic applications
    Patent number: 10329310
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of arginase 1 and arginase 2 activity. The inventions also provides pharmaceutical compositions and methods for using the inventive compounds for treating or preventing a disease or condition associated with arginase activity.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: June 25, 2019
    Assignee: Onco Arendi Therapeutics S.A.
    Inventors: Roman Blaszczyk, Joanna Brzezinska, Adam A. Golebiowski, Jacek Olczak
  • Substituted amino triazoles, and methods using same
    Patent number: 10214531
    Abstract: The invention provides novel substituted amino triazoles of Formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, as well as pharmaceutical compositions comprising the same. The compounds of the invention are inhibitors of acidic mammalian chitinase (AMCase) and are useful, in a non-limiting embodiment, for treating asthma. The invention further provides methods of using compounds and/or compositions of the invention to treat asthma and/or to monitor asthma treatment.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: February 26, 2019
    Assignee: Institute for Drug Discovery, LLC
    Inventors: Michael L. Corman, William M. Hungerford, Adam Golebiowski, Raymond P. Beckett, Marzena Mazur, Sylwia Olejniczak, Jacek Olczak
  • Substituted amino triazoles useful as human chitinase inhibitors
    Patent number: 10208020
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: February 19, 2019
    Assignee: OncoArendi Therapeutics S.A.
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elżbieta Maziarz, Michal Łukasz Kowalski
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS
    Publication number: 20180258071
    Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Application
    Filed: February 28, 2018
    Publication date: September 13, 2018
    Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal Lukasz Kowalski
  • INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20180251479
    Abstract: Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.
    Type: Application
    Filed: May 7, 2018
    Publication date: September 6, 2018
    Inventors: Michael Van Zandt, Adam Golebiowski, Min K. Ji, Darren Whitehouse, Todd Ryder, Raymond P. Beckett