Patents by Inventor Adam Heikal

Adam Heikal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11958842
    Abstract: A combination product comprising a carbapenem and a compound of formula (I?), or a pharmaceutically acceptable salt thereof: a pharmaceutical composition comprising the combination product; and methods of treating bacterial or fungal infections using the combination product and pharmaceutical composition.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: April 16, 2024
    Assignee: ADJUTEC PHARMA AS
    Inventors: Pål Rongved, Ove Alexander Høgmoen Åstrand, Elvar Ørn Viktorsson, Ørjan Samuelson, Adam Heikal, Ole Andreas Løchen Økstad, Geir Kildahl-Andersen
  • Patent number: 11691949
    Abstract: The invention provides novel quinoline sulfonamide compounds of Formula I: and their use for the treatment or prevention of bacterial infections caused by both Gram positive and Gram negative bacteria such as, for example, infections caused by one or more bacteria from the Enterobactericeae, Staphylococcaceae, or Streptococcaceae families. The compounds described and claimed herein may be formulated in one or more pharmaceutical or veterinary compositions for use in animal husbandry, and in particular in relation to the treatment of mastitis by directly targeting mastitis causing bacteria in a bovine herd. In certain embodiments described herein the pharmaceutical or veterinary compositions are formulated as a spray for direct administration to the udder of the bovine animal such as a cow.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: July 4, 2023
    Assignee: OTAGO INNOVATION LIMITED
    Inventors: Margaret Anne Brimble, Greg Murray Cook, Scott Andrew Ferguson, Adam Heikal, David Rennison
  • Publication number: 20210292313
    Abstract: A combination product comprising a carbapenem and a compound of formula (I?), or a pharmaceutically acceptable salt thereof: a pharmaceutical composition comprising the combination product; and methods of treating bacterial or fungal infections using the combination product and pharmaceutical composition.
    Type: Application
    Filed: April 26, 2021
    Publication date: September 23, 2021
    Inventors: Pål Rongved, Ove Alexander Høgmoen Âstrand, Adam Heikal, Elvar Ørn Viktorsson
  • Patent number: 11046678
    Abstract: Compounds of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: June 29, 2021
    Inventors: Pål Rongved, Ove Alexander Høgmoen Åstrand, Adam Heikal, Elvar Ørn Viktorsson
  • Publication number: 20200385354
    Abstract: The invention provides novel quinoline sulfonamide compounds of Formula I: and their use for the treatment or prevention of bacterial infections caused by both Gram positive and Gram negative bacteria such as, for example, infections caused by one or more bacteria from the Enterobactericeae, Staphylococcaceae, or Streptococcaceae families. The compounds described and claimed herein may be formulated in one or more pharmaceutical or veterinary compositions for use in animal husbandry, and in particular in relation to the treatment of mastitis by directly targeting mastitis causing bacteria in a bovine herd. In certain embodiments described herein the pharmaceutical or veterinary compositions are formulated as a spray for direct administration to the udder of the bovine animal such as a cow.
    Type: Application
    Filed: December 20, 2018
    Publication date: December 10, 2020
    Inventors: Margaret Anne BRIMBLE, Greg Murray COOK, Scott Andrew FERGUSON, Adam HEIKAL, David RENNISON
  • Publication number: 20200095237
    Abstract: The invention provides compounds of general formula (I?), and their pharmaceutically acceptable salts: wherein: Z is a group having the formula: -T-S-A-Y in which: T is a group selected from —O—, —NH—, —S—, —(XCR7R8)— (where R7 and R8 is independently —H or C1-3 alkyl and X is selected from from —O—, —NH—, —S—); S is —(C?O)—, —(SO2)—, —(PO2)—; A, —O—, —NH—, —S— or —NH(CO)—, —(CR7R8X)— (where R7 and R8 is independently —H or C1-3 alkyl and X is selected from from —O—, —NH—, —S—), -T-S-A- is a group susceptible to hydrolytic and/or enzymatic cleavage in vivo to leave a group selected from —OH, —NH2, —SH, —COOH, —CONH2, —O—(CR7R8)—COOH and —(CR7R8)—CONH2; Y is one or more targeting groups or a lipophilic or hydrophilic group affecting the solubility in water and the biodistribution in a living organism or a living cell; R1-R6 are independently selected from hydrogen, halogen (e.g. F, Cl, Br, I), lower alkyl (e.g.
    Type: Application
    Filed: December 18, 2017
    Publication date: March 26, 2020
    Inventors: Pål RONGVED, Ove Alexander Høgmoen ÅSTRAND, Adam HEIKAL, Elvar Ørn VIKTORSSON
  • Publication number: 20100279329
    Abstract: There is provided a method for producing purified P-glycoprotein (P-gp) in a stabilised form such that, after being reconstituted into proteoliposomes, it can be freeze dried and stored for prolonged periods of time without loss of biological activity The method comprises the steps of: i) solubilising a mixture of P-gp and other proteins obtained from cell membranes; ii) removing insoluble material by centrifugation; iii) placing the mixture of P-gp and other proteins in a purification column; and iv) running through the purification column at least one wash buffer so as to remove unwanted proteins, and then at least one elution buffer so as to recover the P-gp; wherein one or more of the buffers contains a disaccharide. Trehalose is a particularly preferred disaccharide.
    Type: Application
    Filed: September 3, 2008
    Publication date: November 4, 2010
    Applicant: UNIVERSITY OF BRIGHTON
    Inventors: Adam Heikal, Marcus Allen, Richard Callaghan, Andrew William Lloyd