Abstract: A combination product comprising a carbapenem and a compound of formula (I?), or a pharmaceutically acceptable salt thereof: a pharmaceutical composition comprising the combination product; and methods of treating bacterial or fungal infections using the combination product and pharmaceutical composition.

Abstract: The invention provides novel quinoline sulfonamide compounds of Formula I: and their use for the treatment or prevention of bacterial infections caused by both Gram positive and Gram negative bacteria such as, for example, infections caused by one or more bacteria from the Enterobactericeae, Staphylococcaceae, or Streptococcaceae families. The compounds described and claimed herein may be formulated in one or more pharmaceutical or veterinary compositions for use in animal husbandry, and in particular in relation to the treatment of mastitis by directly targeting mastitis causing bacteria in a bovine herd. In certain embodiments described herein the pharmaceutical or veterinary compositions are formulated as a spray for direct administration to the udder of the bovine animal such as a cow.

Abstract: A combination product comprising a carbapenem and a compound of formula (I?), or a pharmaceutically acceptable salt thereof: a pharmaceutical composition comprising the combination product; and methods of treating bacterial or fungal infections using the combination product and pharmaceutical composition.

Abstract: Compounds of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds.

Abstract: The invention provides novel quinoline sulfonamide compounds of Formula I: and their use for the treatment or prevention of bacterial infections caused by both Gram positive and Gram negative bacteria such as, for example, infections caused by one or more bacteria from the Enterobactericeae, Staphylococcaceae, or Streptococcaceae families. The compounds described and claimed herein may be formulated in one or more pharmaceutical or veterinary compositions for use in animal husbandry, and in particular in relation to the treatment of mastitis by directly targeting mastitis causing bacteria in a bovine herd. In certain embodiments described herein the pharmaceutical or veterinary compositions are formulated as a spray for direct administration to the udder of the bovine animal such as a cow.

Abstract: The invention provides compounds of general formula (I?), and their pharmaceutically acceptable salts: wherein: Z is a group having the formula: -T-S-A-Y in which: T is a group selected from —O—, —NH—, —S—, —(XCR7R8)— (where R7 and R8 is independently —H or C1-3 alkyl and X is selected from from —O—, —NH—, —S—); S is —(C?O)—, —(SO2)—, —(PO2)—; A, —O—, —NH—, —S— or —NH(CO)—, —(CR7R8X)— (where R7 and R8 is independently —H or C1-3 alkyl and X is selected from from —O—, —NH—, —S—), -T-S-A- is a group susceptible to hydrolytic and/or enzymatic cleavage in vivo to leave a group selected from —OH, —NH2, —SH, —COOH, —CONH2, —O—(CR7R8)—COOH and —(CR7R8)—CONH2; Y is one or more targeting groups or a lipophilic or hydrophilic group affecting the solubility in water and the biodistribution in a living organism or a living cell; R1-R6 are independently selected from hydrogen, halogen (e.g. F, Cl, Br, I), lower alkyl (e.g.

Abstract: There is provided a method for producing purified P-glycoprotein (P-gp) in a stabilised form such that, after being reconstituted into proteoliposomes, it can be freeze dried and stored for prolonged periods of time without loss of biological activity The method comprises the steps of: i) solubilising a mixture of P-gp and other proteins obtained from cell membranes; ii) removing insoluble material by centrifugation; iii) placing the mixture of P-gp and other proteins in a purification column; and iv) running through the purification column at least one wash buffer so as to remove unwanted proteins, and then at least one elution buffer so as to recover the P-gp; wherein one or more of the buffers contains a disaccharide. Trehalose is a particularly preferred disaccharide.