Patents by Inventor Adam Hollerbach
Adam Hollerbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230115304Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.Type: ApplicationFiled: December 6, 2022Publication date: April 13, 2023Inventors: Zane Baird, Robert Graham Cooks, Adam Hollerbach, Zheng Ouyang, Michael Pugia
-
Patent number: 11531024Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.Type: GrantFiled: September 24, 2016Date of Patent: December 20, 2022Assignee: Purdue Research FoundationInventors: Zane Baird, Robert Graham Cooks, Adam Hollerbach, Zheng Ouyang, Michael Pugia
-
Publication number: 20210293826Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.Type: ApplicationFiled: June 9, 2021Publication date: September 23, 2021Inventors: Robert Graham Cooks, Zane Baird, Michael Pugia, Adam Hollerbach, Stephen Ayrton
-
Patent number: 11061035Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.Type: GrantFiled: January 20, 2017Date of Patent: July 13, 2021Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Zane Baird, Michael Pugia, Adam Hollerbach, Stephen Ayrton
-
Patent number: 10580634Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.Type: GrantFiled: July 22, 2019Date of Patent: March 3, 2020Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
-
Publication number: 20190348266Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.Type: ApplicationFiled: July 22, 2019Publication date: November 14, 2019Applicant: Purdue Research FoundationInventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
-
Patent number: 10395911Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.Type: GrantFiled: February 1, 2019Date of Patent: August 27, 2019Assignee: Rudue Research FoundationInventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
-
Publication number: 20190180995Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.Type: ApplicationFiled: February 1, 2019Publication date: June 13, 2019Inventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
-
Publication number: 20190128897Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.Type: ApplicationFiled: January 20, 2017Publication date: May 2, 2019Inventors: Robert Graham Cooks, Zane Baird, Michael Pugia, Adam Hollerbach, Stephen Ayrton
-
Patent number: 10242856Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.Type: GrantFiled: March 9, 2016Date of Patent: March 26, 2019Assignee: PURDUE RESEARCH FOUNDATIONInventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach
-
Publication number: 20180275118Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.Type: ApplicationFiled: September 24, 2016Publication date: September 27, 2018Inventors: Baird Zane, Robert Graham Cooks, Adam Hollerbach, Zheng Ouyang, Michael Pugia
-
Publication number: 20180040464Abstract: The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.Type: ApplicationFiled: March 9, 2016Publication date: February 8, 2018Inventors: Robert Graham Cooks, Anyin Li, Adam Hollerbach