Patents by Inventor Adam Safir
Adam Safir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6690179Abstract: One aspect of the present invention provides instruments for measuring mechanical properties of a combinatorial library of materials. The instruments include at least one capacitor to which a member of a library of material samples is removably secured for testing; at least one voltage source for delivering one or more forces to each library member; and at least one sensing device for monitoring the response each library member to the one or more forces. Another aspect of the present invention provides methods of screening a combinatorial library of materials where the method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor.Type: GrantFiled: August 24, 2001Date of Patent: February 10, 2004Assignee: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Patent number: 6653138Abstract: A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.Type: GrantFiled: November 28, 2000Date of Patent: November 25, 2003Assignee: Symyx Technologies, Inc.Inventors: Howard W. Turner, Lynn VanErden, G. Cameron Dales, Adam Safir, Ralph B. Nielsen
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Patent number: 6650102Abstract: The present invention provides instruments and methods for screening combinatorial libraries that addresses many of the problems encountered when using conventional instruments. For example, the disclosed instruments can measure mechanical properties of library members in rapid serial or parallel test format, and can perform tests on small amounts of material, which are easily prepared or dispensed using art-disclosed liquid or solid handling techniques. Compared to conventional instruments, the disclosed instruments afford faster sample loading and unloading, for example, through the use of disposable libraries of material samples.Type: GrantFiled: August 24, 2001Date of Patent: November 18, 2003Assignee: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Publication number: 20030156989Abstract: Parallel semi-continuous or continuous reactors are disclosed. The parallel reactors preferably comprise four or more reaction vessels. The reaction vessels are preferably small volume reaction vessels, preferably pressure reaction vessels, and/or preferably integral with a common reactor block. The reaction vessels can comprise shaft-driven stirrers. At least two, preferably at least three or at least four liquid feed lines can provide selective fluid communication between each of the reaction vessels and one or more liquid reagent sources. Additional features, suitable in connection with parallel reactors or with single reaction vessels are also disclosed.Type: ApplicationFiled: June 1, 2001Publication date: August 21, 2003Inventors: Adam Safir, Ralph Nielsen, Thomas H. McWaid, Richard Tiede, Lynn Van Erden
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Publication number: 20030127776Abstract: A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. Providing the plurality of samples can include a variety of sample formation techniques including, but not limited to, extruding, milling, compression preparation, rotary mixing, microcentrifugation, molding and casting. Preferably, the samples are solidified into a near net shape configuration appropriate for testing of properties or characteristics of the samples.Type: ApplicationFiled: November 8, 2002Publication date: July 10, 2003Applicant: Symyx Technologies, Inc.Inventors: Eric D. Carlson, Damian A. Hajduk, Leonid Matsiev, Adam Safir, Paul Mansky
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Publication number: 20030125484Abstract: A method and apparatus for reacting a plurality of different mixtures in parallel in a semi-batch or continuous mode is provided. Each reaction is contained within a reactor vessel, the reactor vessels combined into a reactor block. Reactant(s) to be added during the reaction are kept in a header barrel, which has a plunger to feed reactant(s) from the header barrel through a transfer line into the reactor vessel. The plunger is moved using a drive system. The header barrels are optionally combined in a header block. The header block is sealed to a plate containing the transfer lines, which in turn is sealed to the reactor block. A latch mechanism is provided for easy sealing of the reactor and header blocks to the plate. The entire apparatus may be placed on a rocker or rotating plate for mixture as the reaction is proceeding.Type: ApplicationFiled: December 9, 2002Publication date: July 3, 2003Applicant: Symyx Technologies, Inc.Inventors: J. Christopher Freitag, Damian Hajduk, Ralph B. Nielsen, Adam Safir, Richard Tiede
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Patent number: 6584832Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed, where the polymer sample, solvent, liquid chromatograph column and/or mobile phase eluant is heated to temperatures of at least 75 degrees Celsius during the sample injection or elution process. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.Type: GrantFiled: February 11, 2002Date of Patent: July 1, 2003Assignee: Symyx Technologies, Inc.Inventors: Miroslav Petro, Adam Safir, Ralph B. Nielsen, G. Cameron Dales, Eric D. Carlson, Thomas S. Lee
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Patent number: 6577392Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.Type: GrantFiled: November 28, 2000Date of Patent: June 10, 2003Assignee: Symyx Technologies, Inc.Inventors: Ralph B. Nielsen, Sigrid C. Kuebler, Thomas S. Lee, Adam Safir, Miroslav Petro
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Patent number: 6566461Abstract: A method and apparatus for reacting a plurality of different mixtures in parallel in a semi-batch or continuous mode is provided. Each reaction is contained within a reactor vessel, the reactor vessels combined into a reactor block. Reactant(s) to be added during the reaction are kept in a header barrel, which has a plunger to feed reactant(s) from the header barrel through a transfer line into the reactor vessel. The plunger is moved using a drive system. The header barrels are optionally combined in a header block. The header block is sealed to a plate containing the transfer lines, which in turn is sealed to the reactor block. A latch mechanism is provided for easy sealing of the reactor and header blocks to the plate. The entire apparatus may be placed on a rocker or rotating plate for mixture as the reaction is proceeding.Type: GrantFiled: January 4, 2001Date of Patent: May 20, 2003Assignee: Symyx Technologies, Inc.Inventors: J. Christopher Freitag, Damian Hajduk, Ralph B. Nielsen, Adam Safir, Richard Tiede
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Publication number: 20030086822Abstract: A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.Type: ApplicationFiled: October 7, 2002Publication date: May 8, 2003Applicant: Symyx Technologies, Inc.Inventors: Howard W. Turner, Lynn VanErden, G. Cameron Dales, Adam Safir, Ralph B. Nielsen
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Patent number: 6559255Abstract: Nitroxides having an alpha-carbon atom with a destabilizing moiety are effective control agents for emulsion and water-based polymerizations, including the formation of block copolymers from a wide range of monomers. The nitroxide radicals may be used as a free radical or as an adduct with a residue from the initiator. The emulsions have living characteristics, including the re-initiation of polymer chains. Also, a seeded process for emulsions, which includes the step-wise addition of monomer is disclosed, providing access to a wide range of initiator types.Type: GrantFiled: March 8, 2000Date of Patent: May 6, 2003Assignee: Symyx Technologies Inc.Inventors: Gerrit Klaerner, Adam Safir, Ralph B. Nielsen, Bernd Jandeleit, Peter Huefner, Yunxiao Li
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Publication number: 20030041671Abstract: A method for high throughput mechanical property testing of materials libraries using capacitance. The method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor.Type: ApplicationFiled: August 24, 2001Publication date: March 6, 2003Applicant: Symyx Technologies, IncInventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Publication number: 20030041676Abstract: A method for high throughput mechanical property testing of materials libraries using a piezoelectric. A plurality of samples on a substrate are monitored for their response to a force applied piezoelectrically.Type: ApplicationFiled: August 24, 2001Publication date: March 6, 2003Applicant: SYMYX Technologies, Inc.Inventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Publication number: 20030041672Abstract: A method for high throughput mechanical property and bulge testing of materials libraries. A plurality of samples on a substrate are monitored for their response to a force from a fluid.Type: ApplicationFiled: August 24, 2001Publication date: March 6, 2003Applicant: Symyx Technologies , Inc.Inventors: Damian A. Hajduk, Eric D. Carlson, J. Christopher Freitag, Oleg Kolosov, James R. Engstrom, Adam Safir, Ravi Srinivasan, Leonid Matsiev
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Patent number: 6528026Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: GrantFiled: November 19, 1998Date of Patent: March 4, 2003Assignee: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Ralph B. Nielsen, Adam Safir, Leonid Matsiev, Eric McFarland, Paul Mansky
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Publication number: 20030026736Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: ApplicationFiled: April 29, 2002Publication date: February 6, 2003Applicant: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Ralph B. Nielsen, Adam Safir, Leonid Matsiev, Eric McFarland, Paul Mansky
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Patent number: 6508984Abstract: A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.Type: GrantFiled: July 19, 2000Date of Patent: January 21, 2003Assignee: Symyx Technologies, Inc.Inventors: Howard W. Turner, Lynn VanErden, G. Cameron Dales, Adam Safir, Ralph B. Nielsen
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Patent number: 6491823Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.Type: GrantFiled: November 28, 2000Date of Patent: December 10, 2002Assignee: Symyx Technologies, Inc.Inventors: Adam Safir, Miroslav Petro, Ralph B. Nielsen, Eric Carlson
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Patent number: 6492184Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.Type: GrantFiled: June 21, 2001Date of Patent: December 10, 2002Assignee: Symyx Technologies, Inc.Inventors: Miroslav Petro, Adam Safir, Ralph B. Nielsen, Thomas S. Lee
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Publication number: 20020174713Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.Type: ApplicationFiled: February 11, 2002Publication date: November 28, 2002Inventors: Miroslav Petro, Adam Safir, Ralph B. Nielsen, G. Cameron Dales, Eric D. Carlson, Thomas S. Lee