Abstract: The embodiments described herein relate generally to medical devices that are useful for delivering one or more therapeutic agents to a body tissue of a subject, and methods for making and using such devices. In particular, the embodiments relate to a medical device such as a stent having a sidewall structure comprising a plurality of struts, in which one or more therapeutic agents are released from different surfaces of the struts at different release profiles. More particularly, the embodiments relate to a stent having a sidewall structure comprising a plurality of struts, in which the two side surfaces of each strut are coated with a coating composition that is different from the coating composition used to coat the outer surface and/or inner surface of the strut.