Patents by Inventor Adela Ben-Yakar
Adela Ben-Yakar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240094193Abstract: A microfluidic device capable of trapping contents in a manner suitable for high-throughput imaging is described herein. The microfluidic device may include one or more trapping devices, with each trapping device having a plurality of trapping channels. The trapping channels may be configured to receive contents via an inlet channel that connects a sample reservoir to the trapping channels via fluid communication. The trapping channels are shaped such that contents within the trapping channels are positioned for optimal imaging purposes. The trapping channels are also connect to at least one exit channel via fluid communication. The fluid, and contents within the fluid, maybe controlled via hydraulic pressure.Type: ApplicationFiled: August 14, 2023Publication date: March 21, 2024Inventors: Adela Ben-Yakar, Evan Hegarty, Sudip Mondal, Navid Ghorashian, Sertan Kutal Gökçe, Christopher Martin
-
Publication number: 20230270333Abstract: Imaging components and systems are described herein. An example imaging component can include: a housing; at least one excitation optical element at least partially disposed within the housing; at least one laser-guiding element at least partially disposed within the housing, the at least one laser-guiding element being configured to deliver excitation pulses to a target location through the at least one excitation optical element via an aperture; and a signal collecting element disposed adjacent to the at least one excitation optical element.Type: ApplicationFiled: January 23, 2023Publication date: August 31, 2023Inventors: Adela Ben-Yakar, Kaushik Subramanian, Ilan Gabay, Liam Andrus, Berk Camli
-
Patent number: 11726084Abstract: A microfluidic device capable of trapping contents in a manner suitable for high-throughput imaging is described herein. The microfluidic device may include one or more trapping devices, with each trapping device having a plurality of trapping channels. The trapping channels may be configured to receive contents via an inlet channel that connects a sample reservoir to the trapping channels via fluid communication. The trapping channels are shaped such that contents within the trapping channels are positioned for optimal imaging purposes. The trapping channels are also connect to at least one exit channel via fluid communication. The fluid, and contents within the fluid, may be controlled via hydraulic pressure.Type: GrantFiled: January 20, 2020Date of Patent: August 15, 2023Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Adela Ben-Yakar, Evan Hegarty, Sudip Mondal, Navid Ghorashian, Sertan Kutal Gökçe, Christopher Martin
-
Patent number: 11714270Abstract: A laser scanning system for capturing an image of a specimen is described herein. The laser scanning system includes a light source configured to emit a light beam for illuminating the specimen, a scanning unit including a plurality of reflectors for scanning the light beam along first and second axes, and a data acquisition unit configured to control acquisition of the image. The laser scanning system can include a control circuit configured to receive a reference clock signal for the first reflector and generate a synchronization clock signal based on the reference clock signal. The laser scanning system can include a synchronization controller configured to control the scanning unit and the data acquisition unit. The synchronization controller can be configured to receive the synchronization clock signal, receive a plurality of imaging parameters, and generate a plurality of control signals based on the synchronization clock signal and the imaging parameters.Type: GrantFiled: July 6, 2020Date of Patent: August 1, 2023Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Adela Ben-Yakar, Ki Hyun Kim, Evan Hegarty, Sertan Kutal Gokce, Sudip Mondal
-
Patent number: 11192109Abstract: Microfluidic devices for the rapid and automated processing of sample populations are provided. Described are multiplexer microfluidic devices configured to serially deliver a plurality of distinct sample populations to a sample processing element rapidly and automatically, without cross-contaminating the distinct sample populations. Also provided are microfluidic sample processing elements that can be used to rapidly and automatically manipulate and/or interrogate members of a sample population. The microfluidic devices can be used to improve the throughput and quality of experiments involving model organisms, such as C. elegans.Type: GrantFiled: July 18, 2018Date of Patent: December 7, 2021Assignee: Board of Regents, The University of Texas SystemInventors: Adela Ben-Yakar, Navid Ghorashian, Sertan Kutal Gökçe, Sam Xun Guo, William Neil Everett, Frederic Bourgeois
-
Publication number: 20210161385Abstract: Disclosed herein are systems and methods for line excitation array detection (LEAD) microscopy. The systems and methods include an excitation beam from an optical beam source and a subject of interest. Light is scanned across the subject of interest and optical signals are detected using a parallel optical detection means.Type: ApplicationFiled: May 10, 2019Publication date: June 3, 2021Inventors: Adela BEN-YAKAR, Tianqi LI, Chris MARTIN, Peisen ZHAO
-
Publication number: 20200333574Abstract: A laser scanning system for capturing an image of a specimen is described herein. The laser scanning system includes a light source configured to emit a light beam for illuminating the specimen, a scanning unit including a plurality of reflectors for scanning the light beam along first and second axes, and a data acquisition unit configured to control acquisition of the image. The laser scanning system can include a control circuit configured to receive a reference clock signal for the first reflector and generate a synchronization clock signal based on the reference clock signal. The laser scanning system can include a synchronization controller configured to control the scanning unit and the data acquisition unit. The synchronization controller can be configured to receive the synchronization clock signal, receive a plurality of imaging parameters, and generate a plurality of control signals based on the synchronization clock signal and the imaging parameters.Type: ApplicationFiled: July 6, 2020Publication date: October 22, 2020Inventors: Adela Ben-Yakar, Ki Hyun Kim, Evan Hegarty, Sertan Kutal Gokce, Sudip Mondal
-
Publication number: 20200158717Abstract: A microfluidic device capable of trapping contents in a manner suitable for high-throughput imaging is described herein. The microfluidic device may include one or more trapping devices, with each trapping device having a plurality of trapping channels. The trapping channels may be configured to receive contents via an inlet channel that connects a sample reservoir to the trapping channels via fluid communication. The trapping channels are shaped such that contents within the trapping channels are positioned for optimal imaging purposes. The trapping channels are also connect to at least one exit channel via fluid communication. The fluid, and contents within the fluid, may be controlled via hydraulic pressure.Type: ApplicationFiled: January 20, 2020Publication date: May 21, 2020Inventors: Adela Ben-Yakar, Evan Hegarty, Sudip Mondal, Navid Ghorashian, Sertan Kutal Gökçe, Christopher Martin
-
Patent number: 10539554Abstract: A microfluidic device capable of trapping contents in a manner suitable for high-throughput imaging is described herein. The microfluidic device may include one or more trapping devices, with each trapping device having a plurality of trapping channels. The trapping channels may be configured to receive contents via an inlet channel that connects a sample reservoir to the trapping channels via fluid communication. The trapping channels are shaped such that contents within the trapping channels are positioned for optimal imaging purposes. The trapping channels are also connect to at least one exit channel via fluid communication. The fluid, and contents within the fluid, may be controlled via hydraulic pressure.Type: GrantFiled: October 27, 2015Date of Patent: January 21, 2020Assignee: Board of Regents, The University of Texas SystemInventors: Adela Ben-Yakar, Evan Hegarty, Sudip Mondal, Navid Ghorashian, Sertan Kutal Gökçe, Christopher Martin
-
Publication number: 20190232288Abstract: Microfluidic devices for the rapid and automated processing of sample populations are provided. Described are multiplexer microfluidic devices configured to serially deliver a plurality of distinct sample populations to a sample processing element rapidly and automatically, without cross-contaminating the distinct sample populations. Also provided are microfluidic sample processing elements that can be used to rapidly and automatically manipulate and/or interrogate members of a sample population. The microfluidic devices can be used to improve the throughput and quality of experiments involving model organisms, such as C. elegans.Type: ApplicationFiled: July 18, 2018Publication date: August 1, 2019Inventors: Adela Ben-Yakar, Navid Ghorashian, Sertan Kutal Gökçe, Sam Xun Guo, William Neil Everett, Frederic Bourgeois
-
Publication number: 20180267284Abstract: A laser scanning system for capturing an image of a specimen is described herein. The laser scanning system includes a light source configured to emit a light beam for illuminating the specimen, a scanning unit including a plurality of reflectors for scanning the light beam along first and second axes, and a data acquisition unit configured to control acquisition of the image. The laser scanning system can include a control circuit configured to receive a reference clock signal for the first reflector and generate a synchronization clock signal based on the reference clock signal. The laser scanning system can include a synchronization controller configured to control the scanning unit and the data acquisition unit. The synchronization controller can be configured to receive the synchronization clock signal, receive a plurality of imaging parameters, and generate a plurality of control signals based on the synchronization clock signal and the imaging parameters.Type: ApplicationFiled: January 29, 2016Publication date: September 20, 2018Applicant: Board of Regents, The University of Texas SystemInventors: Adela Ben-Yakar, Ki Hyun Kim, Evan Hegarty, Sertan Kutal Gokce, Sudip Mondal
-
Patent number: 10052631Abstract: Microfluidic devices for the rapid and automated processing of sample populations are provided. Described are multiplexer microfluidic devices configured to serially deliver a plurality of distinct sample populations to a sample processing element rapidly and automatically, without cross-contaminating the distinct sample populations. Also provided are microfluidic sample processing elements that can be used to rapidly and automatically manipulate and/or interrogate members of a sample population. The microfluidic devices can be used to improve the throughput and quality of experiments involving model organisms, such as C. elegans.Type: GrantFiled: March 5, 2014Date of Patent: August 21, 2018Assignee: Board of Regents, The University of Texas SystemInventors: Adela Ben-Yakar, Navid Ghorashian, Sertan Kutal Gökçe, Sam Xun Guo, William Neil Everett, Frederic Bourgeois
-
Patent number: 9333036Abstract: Provided herein are devices, systems and methods for treating a vocal fold pathology by forming a substantially planar void below the epithelium of the vocal fold using optical energy. Also provided are devices, systems, and methods for combined imaging and treating of a vocal fold pathology.Type: GrantFiled: January 21, 2011Date of Patent: May 10, 2016Assignees: Board of Regents, The University of Texas System, The General Hospital CorporationInventors: Adela Ben-Yakar, Christopher L. Hoy, William Neil Everett, James B. Kobler, Richard Rox Anderson, William A. Farinelli, Steven M. Zeitels
-
Publication number: 20160016169Abstract: Microfluidic devices for the rapid and automated processing of sample populations are provided. Described are multiplexer tiplexer microfluidic devices configured to serially deliver a plurality of distinct sample populations to a sample processing element rapidly and automatically, without cross-contaminating the distinct sample populations. Also provided are microfluidic sample processing elements that can be used to rapidly and automatically manipulate and/or interrogate members of a sample population. The microfluidic devices can be used to improve the throughput and quality of experiments involving model organisms, such as C. elegans.Type: ApplicationFiled: March 5, 2014Publication date: January 21, 2016Inventors: Adela Ben-Yakar, Navid Ghorashian, Sertan Kutal Gökçe, Sam Xun Guo, William Neil Everett, Frederic Bourgeois
-
Publication number: 20150036234Abstract: Disclosed are compositions and methods for making and using thin film opto-electronic conversion devices using nanoparticles.Type: ApplicationFiled: August 1, 2014Publication date: February 5, 2015Inventors: Adela Ben-Yakar, Richard K. Harrison
-
Patent number: 8894637Abstract: Provided herein are devices, systems and methods for imaging of biological tissue. Also provided are devices, systems and methods for surgical manipulation of biological tissue. Further provided are devices, systems and methods for combined imaging and surgical manipulation of biological tissue.Type: GrantFiled: January 22, 2009Date of Patent: November 25, 2014Assignees: Board of Regents, The University of Texas System, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Adela Ben-Yakar, Christopher L. Hoy, Olav Solgaard
-
Patent number: 7834331Abstract: A novel femtosecond laser nano-ablation technique called Plasmonic Laser Nano-Ablation (PLN). The technique takes advantage of surface-enhanced plasmonic scattering of ultrashort laser pulses by nanoparticles to vaporize sub-cellular structures in attoliter volumes. The use of nanoparticles may overcome problems associated with current FLMS techniques and does not rely on heating for nanodisruption. In PLN, the particle acts as a “nano-lens,” restricting laser light to the near-field of the particle, and only photodisrupting structures that are nanometers away. This eliminates the need for a tightly focused beam, while still achieving nanoscale ablation resolution. Moreover, the enhanced scattering around the particles reduces the amount of required laser fluence.Type: GrantFiled: August 1, 2008Date of Patent: November 16, 2010Assignee: Board of Regents, The University of Texas SystemInventors: Adela Ben-Yakar, Daniel Eversole, Xun Guo
-
Publication number: 20100286674Abstract: Provided herein are devices, systems and methods for imaging of biological tissue. Also provided are devices, systems and methods for surgical manipulation of biological tissue. Further provided are devices, systems and methods for combined imaging and surgical manipulation of biological tissue.Type: ApplicationFiled: January 22, 2009Publication date: November 11, 2010Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, BOARD OF TRUSSTESS OF THE LELAND STANFORD JUNIOR UInventors: Adela Ben-Yakar, Christopher L. Hoy, Olav Solgaard
-
Publication number: 20090072161Abstract: A novel femtosecond laser nano-ablation technique called Plasmonic Laser Nano-Ablation (PLN). The technique takes advantage of surface-enhanced plasmonic scattering of ultrashort laser pulses by nanoparticles to vaporize sub-cellular structures in attoliter volumes. The use of nanoparticles may overcome problems associated with current FLMS techniques and does not rely on heating for nanodisruption. In PLN, the particle acts as a “nano-lens,” restricting laser light to the near-field of the particle, and only photodisrupting structures that are nanometers away. This eliminates the need for a tightly focused beam, while still achieving nanoscale ablation resolution. Moreover, the enhanced scattering around the particles reduces the amount of required laser fluence.Type: ApplicationFiled: August 1, 2008Publication date: March 19, 2009Inventors: Adela Ben-Yakar, Daniel Eversole, Xun Guo