Abstract: An atherectomy device is provided wherein a catheter has a cutting region including plurality of slotted tubular members interconnected by flexible segments. Each slotted tubular member includes cutting edges that sever occlusive material from the interior of a vessel when the cutting region is rotated. The flexible segments may be formed by cutting windows in a tapered hollow tubular member, or may comprise bellows-shaped tubes or helical coils, and may be coated with a flexible material allowing suction to be drawn through the device, or to permit the delivery of contrast agents, dyes, fluids or drugs to the operative site. A guide catheter also may be provided for positioning the cutting region of the atherectomy device at the operative site.