Patents by Inventor Adrian Fehr
Adrian Fehr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230175060Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: ApplicationFiled: September 7, 2022Publication date: June 8, 2023Inventors: Adrian FEHR, Nathaniel Joseph MCCAFFREY, Stephen TURNER
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Publication number: 20210340616Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: ApplicationFiled: March 30, 2021Publication date: November 4, 2021Inventors: Adrian FEHR, Nathaniel Joseph McCAFFREY, Stephen TURNER
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Patent number: 11001889Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: GrantFiled: November 26, 2018Date of Patent: May 11, 2021Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Publication number: 20190360042Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: ApplicationFiled: November 26, 2018Publication date: November 28, 2019Inventors: Adrian Fehr, Nathaniel Joseph McCAFFREY, Stephen TURNER
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Patent number: 10138515Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: GrantFiled: September 3, 2015Date of Patent: November 27, 2018Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Publication number: 20170030834Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: ApplicationFiled: June 28, 2016Publication date: February 2, 2017Inventors: Adrian FEHR, Nathaniel Joseph MCCAFFREY, Stephen TURNER
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Patent number: 9410891Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: GrantFiled: February 18, 2011Date of Patent: August 9, 2016Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Patent number: 9381517Abstract: Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.Type: GrantFiled: January 7, 2014Date of Patent: July 5, 2016Assignee: Pacific Biosciences of California, Inc.Inventors: Thang Pham, Jeremy Gray, Adrian Fehr, AJ Chmura, Yu-Chih Tsai, Arunashree Bhamidipati
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Patent number: 9291569Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: GrantFiled: March 9, 2015Date of Patent: March 22, 2016Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Publication number: 20160069806Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: ApplicationFiled: September 3, 2015Publication date: March 10, 2016Applicant: Pacific Biosciences of California, Inc.Inventors: Adrian FEHR, Nathaniel Joseph McCaffrey, Stephen TURNER
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Patent number: 9157864Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: GrantFiled: May 16, 2013Date of Patent: October 13, 2015Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Publication number: 20150247800Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.Type: ApplicationFiled: March 9, 2015Publication date: September 3, 2015Inventors: Adrian FEHR, Nathaniel Joseph McCAFFREY, Stephen TURNER
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Patent number: 9017937Abstract: The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. The invention includes devices having sample and reference pores connecting sample, measurement and reference chambers, wherein potential measurements in each chamber is used to provide an accurate determination of current through a sample nanopore, improving nanopore sequencing.Type: GrantFiled: April 8, 2011Date of Patent: April 28, 2015Assignee: Pacific Biosciences of California, Inc.Inventors: Stephen Turner, Nathaniel McCaffrey, Jeffrey Wegener, Adrian Fehr
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Patent number: 8986928Abstract: The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed.Type: GrantFiled: April 9, 2010Date of Patent: March 24, 2015Assignee: Pacific Biosciences of California, Inc.Inventors: Stephen Turner, Benjamin Flusberg, Mathieu Foquet, Hans Callebaut, Robert Sebra, Bidhan Chaudhuri, Jon Sorenson, Keith Bjornson, Adrian Fehr, Jonas Korlach, Robin Emig
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Patent number: 8906831Abstract: Methods for non-random loading of single analyte molecules into array structures are provided. The methods allow for distribution of a population of target molecules into a plurality of size confined regions such as wells. Sizing moieties are linked to individual target molecules. The sizing moieties are of sufficient size, relative to the size-confined reaction or observation regions, such that only a selected number of sizing moieties will fit into the size confined regions. The confined regions and the sizing moieties or target molecules comprise a selected charge that allow for controlling the loading of the sizing moities.Type: GrantFiled: March 30, 2009Date of Patent: December 9, 2014Assignee: Pacific Biosciences of California, Inc.Inventors: John Eid, Stephen Turner, Ravi Dalal, Benjamin Flusberg, Jonas Korlach, Steven Lin, Adrian Fehr, Fred Christians, Robin Emig, Jeremy Gray, Robert Sebra, Lei Sun, Stephen Dudek
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Publication number: 20140193315Abstract: Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.Type: ApplicationFiled: January 7, 2014Publication date: July 10, 2014Applicant: Pacific Biosciences of California, Inc.Inventors: Thang Pham, Jeremy Gray, Adrian Fehr, Aj Chmura, Yu-Chih Tsai, Arunashree Bhamidipati
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Patent number: 8715930Abstract: Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.Type: GrantFiled: March 23, 2012Date of Patent: May 6, 2014Assignee: Pacific Biosciences of California, Inc.Inventors: Thang Pham, Jeremy Gray, Adrian Fehr, Albert James Chmura, Yu-Chih Tsai, Arunashree Bhamidipati
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Publication number: 20130330731Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: ApplicationFiled: May 16, 2013Publication date: December 12, 2013Applicant: Pacific Biosciences of California, Inc.Inventors: Adrian FEHR, Nathaniel Joseph McCaffrey, Stephen Turner
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Patent number: 8465699Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.Type: GrantFiled: February 18, 2011Date of Patent: June 18, 2013Assignee: Pacific Biosciences of California, Inc.Inventors: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
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Patent number: RE47067Abstract: The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. The invention includes devices having sample and reference pores connecting sample, measurement and reference chambers, wherein potential measurements in each chamber is used to provide an accurate determination of current through a sample nanopore, improving nanopore sequencing.Type: GrantFiled: July 28, 2015Date of Patent: October 2, 2018Assignee: Pacific Biosciences of California, Inc.Inventors: Stephen Turner, Nathaniel McCaffrey, Jeffrey Wegener, Adrian Fehr