Abstract: The present invention relates to tetrahydroisoquinolinyl derivatives of formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

Abstract: A method for supporting and/or making clinical decisions, especially with relation to cannabis use, that uses computer analytics to automatically analyze data to determine which data is relevant to account for changes in a patient over time, continually improves on that analytical process, and offers predictions, insights, and/or suggestions to support clinical decision making.

Abstract: The present invention relates to octahydroisoquinolinyl derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

Abstract: Provided herein are compounds and compositions that inhibit telomerase and/or the TERT gene with a mutant promoter. Further provided are small molecule compounds or compositions having beneficial effects in cancer treatment. Methods of making the compounds and compositions and methods of using the compounds and compositions, such as using the compounds and compositions to treat cancer, are also provided.

Abstract: An automatic system for making clinical decisions, especially with relation to cannabis use, that incorporates data from multiple personal tracking devices such as fitness trackers, analyzes that data using machine learning techniques to determine which data points are relevant to account for changes over time, and offers predictions, insights, and/or suggestions to support clinical decision making.

Abstract: Provided are systems and methods for determining and displaying service performance information via a graphical user interface. In one embodiment, a system can provide, for each of one or more machines associated with a service: obtaining performance data for the machine; and comparing the performance data for the machine to one or more predefined performance thresholds for the machine to determine a health status for the machine; and determining a health status for the service based at least in part on the health status of at least one of the one or more machines associated with the service.

Abstract: Methods for preparing a layered metal nanocomposite and a layered metal nanocomposite. The method includes mixing a magnesium salt and an aluminum salt to form a Mg2+/Al3+ solution. The Mg/Al has a molar ratio of between 0.5:1 to 6:1. Then a diamondoid compound is added to the Mg2+/Al3+ solution to form a reactant mixture. The diamondoid compound has at least one carboxylic acid moiety. The reactant mixture is heated at a reaction temperature for a reaction time to form a Mg/Al-diamondoid intercalated layered double hydroxide. The Mg/Al-diamondoid intercalated layered double hydroxide is thermally decomposed under a reducing atmosphere for a decomposition time at a decomposition temperature to form the layered metal nanocomposite.

Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

Abstract: A system for making clinical decisions.

Abstract: A system for making clinical decisions.

Abstract: A system for making clinical decisions.

Abstract: A system for making clinical decisions.

Abstract: A system for making clinical decisions.

Abstract: Oil-based drilling fluid compositions comprising an oil phase comprising a base oil, an aqueous phase comprising water, at least one emulsifier, and one or more additives. The at least one emulsifier comprises an amino amide comprising the formula R—CO—NH—R?—NH—R?—NH2, where R is a fatty acid alkyl and R? and R? are alkyl groups. The one or more additives are chosen from a wetting agent, a rheology modifier, a fluid-loss control additive, and a weighting additive. Methods of making the oil-based drilling fluid compositions and methods of drilling a subterranean well utilizing the oil-based drilling fluid compositions are also provided.

Abstract: A method of preparing and a composition of an oil-based drilling fluid. An oil-based drilling fluid includes a base oil continuous phase, in which the base oil continuous phase includes a base oil, an aqueous dispersed phase, and at least one rheology modifier comprising a modified magnesium/aluminum carbonate layered-double hydroxide (Mg/Al—CO3 LDH) compound.

Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

Abstract: Methods for preparing a layered metal nanocomposite and a layered metal nanocomposite. The method includes mixing a magnesium salt and a aluminum salt to form a Mg2+/Al3+ solution. The Mg/Al has a molar ratio of between 0.5:1 to 6:1. Then a diamondoid compound is added to the Mg2+/Al3+ solution to form a reactant mixture. The diamondoid compound has at least one carboxylic acid moiety. The reactant mixture is heated at a reaction temperature for a reaction time to form a Mg/Al-diamondoid intercalated layered double hydroxide. The Mg/Al-diamondoid intercalated layered double hydroxide is thermally decomposed under a reducing atmosphere for a decomposition time at a decomposition temperature to form the layered metal nanocomposite.

Abstract: Oil-based drilling fluid compositions comprising an oil phase comprising a base oil, an aqueous phase comprising water, at least one emulsifier, and one or more additives. The at least one emulsifier comprises an amino amide comprising the formula R—CO—NH—R?—NH2, where R is a fatty acid alkyl and R? is an alkyl group. The one or more additives are chosen from a wetting agent, a rheology modifier, a fluid-loss control additive, and a weighting additive. Methods of making the oil-based drilling fluid compositions and methods of drilling a subterranean well utilizing the oil-based drilling fluid compositions are also provided.

Abstract: The present invention relates to bis-heteroaryl compounds of formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

Abstract: Embodiments are directed to adamantane-intercalated layered double-hydroxide (LDH) particles and the methods of producing adamantane-intercalated LDH particles. The adamantane-intercalated LDH particles have a general formula defined by [M1-xAlx(OH)2](A)x.mH2O, where x is from 0.14 to 0.33, m is from 0.33 to 0.50, M is chosen from Mg, Ca, Co, Ni, Cu, or Zn, and A is adamantane carboxylate. The adamantane-intercalated LDH particles further have an aspect ratio greater than 100. The aspect ratio is defined by the width of an adamantane-intercalated LDH particle divided by the thickness of the adamantane-intercalated LDH particle.