Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: A warning light (10) for external use on an aircraft comprises a high-intensity light output light source (14,20). The light source comprises a plurality of light emitting diodes (40) which are arranged to be pulsed with an overdriving signal (32) to produce a higher than normal intensity flashing light output. The overdriving signal (32) is generated by a pulsed drive circuit (30) in response to timing signals received from a flash pattern box at a rate of between 0.67 Hz to 1.67 Hz.

Abstract: A warning light (10) for external use on an aircraft comprises a high-intensity light output light source (14,20). The light source comprises a plurality of light emitting diodes (40) which are arranged to be pulsed with an overdriving signal (32) to produce a higher than normal intensity flashing light output. The overdriving signal (32) is generated by a pulsed drive circuit (30) in response to timing signals received from a flash pattern box at a rate of between 0.67 Hz to 1.67 Hz.

Abstract: A phosphate glass doped with copper in an amount of less than 2% by weight is formed to produce a lens for use on external aircraft lights. The glass attenuates infra red radiation to a degree where it does not pose a danger of temporarily blinding a pilot wearing night vision goggles yet remains visible. The glass has little appreciable effect on light transmission in the visible spectrum. Conveniently, the glass can be formed by slumping at a softening temperature against a mold to produce intricate lens shapes. In addition, the glass is able to withstand conventional toughening processes.