Patents by Inventor Adriana Marie Rus

Adriana Marie Rus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND MEANS FOR EFFICIENT DKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-MRNA
    Publication number: 20230151362
    Abstract: The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with an antisense molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such antisense molecule used in said method.
    Type: Application
    Filed: July 25, 2022
    Publication date: May 18, 2023
    Inventors: Josephus Johannes de Kimpe, Adriana Marie Rus, Gerard Johannes Platenburg, Judith Christina Theodora van Deutekom, Garrit-Jan Boudewijn van Ommen
  • Methods and means for efficient skipping of exon 45 in Duchenne muscular dystrophy pre-mRNA
    Patent number: 11427820
    Abstract: The. invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with an antisense molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such antisense molecule used in said method.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: August 30, 2022
    Assignees: BioMarin Technologies B.V., Academisch Ziekenbuls Leiden
    Inventors: Josephus Johannes De Kimpe, Adriana Marie Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
  • METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
    Publication number: 20200239886
    Abstract: The. invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with an antisense molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such antisense molecule used in said method.
    Type: Application
    Filed: September 26, 2019
    Publication date: July 30, 2020
    Inventors: Josephus Johannes De Kimpe, Adriana Marie Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
  • METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
    Publication number: 20190177725
    Abstract: The. invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with an antisense molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such antisense molecule used in said method.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 13, 2019
    Inventors: Josephus Johannes De Kimpe, Adriana Marie Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
  • METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
    Publication number: 20190119679
    Abstract: The. invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with an antisense molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such antisense molecule used in said method.
    Type: Application
    Filed: December 21, 2018
    Publication date: April 25, 2019
    Inventors: Josephus Johannes De Kimpe, Adriana Marie Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
  • METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
    Publication number: 20190112604
    Abstract: The. invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with an antisense molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such antisense molecule used in said method.
    Type: Application
    Filed: December 21, 2018
    Publication date: April 18, 2019
    Inventors: Josephus Johannes De Kimpe, Adriana Marie Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
  • METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
    Publication number: 20170107512
    Abstract: The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing an isolate muscle cell with a molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such molecule used in the method.
    Type: Application
    Filed: December 27, 2016
    Publication date: April 20, 2017
    Inventors: Josephus Johannes De KIMPE, Adriana Marie RUS, Gerard Johannes PLATENBURG, Judith Christina Theodora Van DEUTEKOM, Garrit-Jan Boudewijn Van OMMEN
  • Methods and means for efficient skipping of exon 45 in duchenne muscular dystrophy pre-mRNA
    Patent number: 9528109
    Abstract: The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing an isolated muscle cell with a molecule that binds to a continuous stretch of at least 21 nucleotides within the exon. The invention further relates to such molecule used in the method.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: December 27, 2016
    Assignees: BioMarin Technologies B.V., Academisch Ziekenhuis Leiden
    Inventors: Josephus Johannes De Kimpe, Adriana Marie Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
  • Means and methods for modulating NOTCH3 protein expression and/or the coding region of NOTCH3; compositions and use thereof in the treatment of CADASIL
    Patent number: 9353169
    Abstract: The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 mRNA or pre-mRNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 mRNA or pre-mRNA.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: May 31, 2016
    Assignee: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC
    Inventors: Saskia Anne-Marie Jenny Lesnik Oberstein, Garrit-Jan Boudewijn van Ommen, Adriana Marie Rus, Johannes Gregorius Dauwerse
  • MEANS AND METHODS FOR MODULATING NOTCH3 PROTEIN EXPRESSION AND/OR THE CODING REGION OF NOTCH3; COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CADASIL
    Publication number: 20150274796
    Abstract: The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain.
    Type: Application
    Filed: June 12, 2015
    Publication date: October 1, 2015
    Inventors: Saskia Anne-Marie Jenny Lesnik Oberstein, Garrit-Jan Boudewijn van Ommen, Adriana Marie Rus, Johannes Gregorius Dauwerse
  • Means and methods for modulating NOTCH3 protein expression and/or the coding region of NOTCH3; compositions and use thereof in the treatment of CADASIL
    Patent number: 9062311
    Abstract: The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 m RNA or pre-m RNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 m RNA or pre-m RNA.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: June 23, 2015
    Assignee: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC
    Inventors: Saskia Anne-Marie Jenny Lesnik Oberstein, Garrit-Jan Boudewijn van Ommen, Adriana Marie Rus, Johannes Gregorius Dauwerse
  • COMPOUNDS AND METHODS FOR ALTERING ACTIVIN RECEPTOR-LIKE KINASE SIGNALING
    Publication number: 20140088174
    Abstract: Described are compounds and methods useful in the promotion of muscle growth, the treatment of muscle loss or insufficient muscle growth, and the treatment of fibrotic conditions.
    Type: Application
    Filed: April 5, 2012
    Publication date: March 27, 2014
    Applicant: Academisch Ziekenhuis Leiden h.o.d.n. LUMC
    Inventors: Peter Abraham Christiaan "T Hoen, Wilhelmus Martinus Hendrikus Hoogaars, Dwi Utami Kemaladewi, Adriana Marie Rus, Peter Ten Duke
  • MEANS AND METHODS FOR MODULATING NOTCH3 PROTEIN EXPRESSION AND/OR THE CODING REGION OF NOTCH3; COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CADASIL
    Publication number: 20110318787
    Abstract: The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 m RNA or pre-m RNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 m RNA or pre-m RNA.
    Type: Application
    Filed: January 26, 2010
    Publication date: December 29, 2011
    Applicant: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC
    Inventors: Saskia Anne-Marie Jenny Lesnik Oberstein, Garrit-Jan Boudewijn van Ommen, Adriana Marie Rus, Johannes Gregorius Dauwerse