Patents by Inventor Adriano Fontana

Adriano Fontana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of serine protease inhibitors in the treatment of neutropenia
    Patent number: 9642898
    Abstract: The invention relates to therapeutic compounds which are inhibitors of serine proteases, to pharmaceutical compositions thereof and to their use in the treatment of the human or animal body. More specifically, the present invention relates to a method for the treatment of neutropenia comprising the administration to a subject in need thereof of a therapeutically effective amount of a serine protease inhibitor. The invention also comprises prevention of apoptosis of myeloid cells (1) during and after transfection of bone marrow cells performed for gene therapy, (2) during blood stem cell mobilization performed for reconstitution of hematopoiesis and (3) during infusion of cells of the myeloid lineage for reconstitution of hematopoiesis for gene therapy or for treatment of neutropenia by infusion of neutrophils.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: May 9, 2017
    Assignees: MED DISCOVERY S.A., UNIVERSITY OF ZURICH
    Inventors: Adriano Fontana, Mike Recher, Christoph Kundig
  • USE OF SERINE PROTEASE INHIBITORS IN THE TREATMENT OF NEUTROPENIA
    Publication number: 20150165004
    Abstract: The invention relates to therapeutic compounds which are inhibitors of serine proteases, to pharmaceutical compositions thereof and to their use in the treatment of the human or animal body. More specifically, the present invention relates to a method for the treatment of neutropenia comprising the administration to a subject in need thereof of a therapeutically effective amount of a serine protease inhibitor. The invention also comprises prevention of apoptosis of myeloid cells (1) during and after transfection of bone marrow cells performed for gene therapy, (2) during blood stem cell mobilization performed for reconstitution of hematopoiesis and (3) during infusion of cells of the myeloid lineage for reconstitution of hematopoiesis for gene therapy or for treatment of neutropenia by infusion of neutrophils.
    Type: Application
    Filed: November 21, 2014
    Publication date: June 18, 2015
    Applicants: UNIVERSITY OF ZURICH, MED DISCOVERY S.A.
    Inventors: Adriano FONTANA, Mike RECHER, Christoph KUNDIG
  • Use Of Serine Protease Inhibitors In The Treatment Of Neutropenia
    Publication number: 20120004395
    Abstract: The invention relates to therapeutic compounds which are inhibitors of serine proteases, to pharmaceutical compositions thereof and to their use in the treatment of the human or animal body. More specifically, the present invention relates to a method for the treatment of neutropenia comprising the administration to a subject in need thereof of a therapeutically effective amount of a serine protease inhibitor. The invention also comprises prevention of apoptosis of myeloid cells (1) during and after transfection of bone marrow cells performed for gene therapy, (2) during blood stem cell mobilization performed for reconstitution of hematopoiesis and (3) during infusion of cells of the myeloid lineage for reconstitution of hematopoiesis for gene therapy or for treatment of neutropenia by infusion of neutrophils.
    Type: Application
    Filed: March 10, 2010
    Publication date: January 5, 2012
    Applicants: UNIVERSITY OF ZURICH, MED DISCOVERY SA
    Inventors: Adriano Fontana, Mike Recher, Christoph Kundig
  • Immunosuppressant factor protein capable of inhibiting T-cell mechanisms
    Patent number: 5095095
    Abstract: An immunosuppressant factor derived from human glioblastoma cells.
    Type: Grant
    Filed: July 13, 1990
    Date of Patent: March 10, 1992
    Assignee: Sandoz Ltd.
    Inventor: Adriano Fontana