Patents by Inventor Adrienne Mccampbell
Adrienne Mccampbell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11982606Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.Type: GrantFiled: February 27, 2020Date of Patent: May 14, 2024Assignee: Agilent Technologies, Inc.Inventors: Victor Lim, Carol T. Schembri, Adrienne Mccampbell, Nazumi Alice Yama-Dang
-
Publication number: 20240102932Abstract: The present disclosure is directed to an improved methods and systems using autofluorescence of naturally-occurring components in a sample embedded in an embedding medium. Methods and systems are provided for determining an amount of tissue or cell preparation exposed at a surface of an embedded sample, and for preparing a tissue specimen comprising a region of interest (ROI) from an embedded sample. Methods and systems are also provided for imaging a sample of a biological tissue, and for identifying different cell types in an embedded tissue sample.Type: ApplicationFiled: December 30, 2021Publication date: March 28, 2024Inventors: Victor LIM, Adrienne MCCAMPBELL, Qingyu WANG
-
Patent number: 11940359Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.Type: GrantFiled: December 29, 2021Date of Patent: March 26, 2024Assignee: Agilent Technologies, Inc.Inventors: Kyle Schleifer, Kristin Briana Bernick, Adrienne Mccampbell, Nicholas M. Sampas, Victor Lim
-
Publication number: 20230407379Abstract: The present methods and apparatus apply an electric field to a sample in order to prepare it for analysis. In some embodiments, an electric field is applied for drying, staining and coverslipping of tissue sections, providing improved tissue sections for analysis and storage.Type: ApplicationFiled: July 30, 2021Publication date: December 21, 2023Inventors: Adrienne McCampbell, Victor Lim, Sean Nasri, Brian Phillip Smart
-
Publication number: 20230236211Abstract: Systems and methods for coverslipping a sample on a slide employ a coverslip tape. The systems and methods can reduce or eliminate the use of xylene and other toxic solvents for coverslipping.Type: ApplicationFiled: June 11, 2021Publication date: July 27, 2023Inventors: Rolfe Anderson, Adrienne Mccampbell, Victor Lim, Carol T. Schembri, Michal Johannsen, Fleming Lassen Nielsen
-
Publication number: 20230053368Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.Type: ApplicationFiled: October 28, 2022Publication date: February 23, 2023Inventors: Adrienne Mccampbell, Victor Lim
-
Patent number: 11525759Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.Type: GrantFiled: April 23, 2019Date of Patent: December 13, 2022Assignee: Agilent Technologies, Inc.Inventors: Adrienne Mccampbell, Victor Lim
-
Publication number: 20220120646Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.Type: ApplicationFiled: December 29, 2021Publication date: April 21, 2022Inventors: Kyle Schleifer, Kristin Briana Bernick, Adrienne Mccampbell, Nicholas M. Sampas, Victor Lim
-
Patent number: 11243148Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.Type: GrantFiled: December 21, 2020Date of Patent: February 8, 2022Assignee: Agilent Technologies, Inc.Inventors: Kyle Schleifer, Kristin Briana Bernick, Adrienne Mccampbell, Nicholas M. Sampas, Victor Lim
-
Publication number: 20210108995Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.Type: ApplicationFiled: December 21, 2020Publication date: April 15, 2021Inventors: Kyle Schleifer, Kristin Briana Bernick, Adrienne Mccampbell, Nicholas M. Sampas, Victor Lim
-
Patent number: 10914658Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.Type: GrantFiled: May 7, 2020Date of Patent: February 9, 2021Assignee: Agilent Technologies, Inc.Inventors: Kyle Schleifer, Kristin Briana Bernick, Adrienne Mccampbell, Nicholas M. Sampas, Victor Lim
-
Publication number: 20200264077Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.Type: ApplicationFiled: May 7, 2020Publication date: August 20, 2020Inventors: Kyle Schleifer, Kristin Briana Bernick, Adrienne Mccampbell, Nicholas M. Sampas, Victor Lim
-
Publication number: 20200200657Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.Type: ApplicationFiled: February 27, 2020Publication date: June 25, 2020Inventors: Victor Lim, Carol T. Schembri, Adrienne Mccampbell, Nazumi Alice Yama-Dang
-
Patent number: 10684199Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.Type: GrantFiled: June 1, 2018Date of Patent: June 16, 2020Assignee: AGILENT TECHNOLOGIES, INC.Inventors: Kyle Schleifer, Kristin Briana Bernick, Adrienne Mccampbell, Nicholas M Sampas, Victor Lim
-
Patent number: 10613005Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.Type: GrantFiled: October 30, 2017Date of Patent: April 7, 2020Assignee: AGILENT TECHNOLOGIES, INC.Inventors: Victor Lim, Carol T. Schembri, Adrienne Mccampbell, Nazumi Alice Yama-Dang
-
Publication number: 20190368982Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.Type: ApplicationFiled: June 1, 2018Publication date: December 5, 2019Inventors: Kyle Schleifer, Kristin Briana Bernick, Adrienne Mccampbell, Nicholas M. Sampas, Victor Lim
-
Publication number: 20190323929Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.Type: ApplicationFiled: April 23, 2019Publication date: October 24, 2019Inventors: Adrienne Mccampbell, Victor Lim
-
Publication number: 20180120207Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.Type: ApplicationFiled: October 30, 2017Publication date: May 3, 2018Inventors: Victor Lim, Carol T. Schembri, Adrienne Mccampbell, Nazumi Alice Yama-Dang