Abstract: The present invention provides a non-toxic diagnostic composition for intravaginal monitoring of vaginal infections. The present invention further provides a diagnostic article for intravaginal monitoring of vaginal infections with the article including an absorbent material for absorbing vaginal secretions and a composition suitable for identification of the pH or the buffer capacities associated with vaginal secretions. The diagnostic composition provides a visible indication of vaginal infections, such as bacterial vaginosis.

Abstract: A method for identifying physiological conditions associated with the pH or the buffer capacities of biological fluid secreted from a person, by providing a secretion-monitoring article of a body that includes an absorbent material for absorbing a biological fluid secreted from a person and an indicator system having a hydrophobic chemical composition that includes an indicator agent and an ion-balance reagent, at specific relative amounts. Optionally, a competitive agent for establishing a pre-set threshold of an analyte of interest in a tested bodily fluid, is added to the indicator system, wherein the indicator reagent being charged oppositely to the analyte of interest and the competitive reagent having the same charge as the indicator reagent.

Abstract: A method for identifying physiological conditions associated with the pH or the buffer capacities of biological fluid secreted from a person, by providing a secretion-monitoring article of a body that includes an absorbent material for absorbing a biological fluid secreted from a person and an indicator system having a hydrophobic chemical composition that includes an indicator agent and an ion-balance reagent, at specific relative amounts. Optionally, a competitive agent for establishing a pre-set threshold of an analyte of interest in a tested bodily fluid, is added to the indicator system, wherein the indicator reagent being charged oppositely to the analyte of interest and the competitive reagent having the same charge as the indicator reagent.

Abstract: The present invention provides a bodily fluid-testing composition for the determination and quantification of a specific ion concentration exceeding a pre-set threshold in a tested fluid, in which an ion oppositely charged to the ion in the bodily fluid is used to compete with an indicator reagent in order to compensate for variability in specific binding of the bodily fluid ions. The present invention further provides an article for monitoring of bodily fluids comprising a substrate and an absorbent material for absorbing the bodily fluid. The substrate includes a composition suitable for identification of a specific ion concentration in a tested fluid. The article can be used to indicate the presence of abnormal ammonium concentration in human urine, amniotic fluid leakage, or biogenic secretions associated with bacterial vaginosis, parasite infections, or deficiency of lactobacillus population, without giving a false positive result.