Patents by Inventor Agata Exner

Agata Exner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TUNABLE, STABLE SCLEROSING FOAM FOR VASCULAR INTERVENTIONS
    Publication number: 20240165294
    Abstract: A sclerosing foam includes a liquid phase and a gas phase, wherein the liquid phase comprises at least one sclerosing agent and the gas phase comprises at least about 50% by volume of a pefluorocarbon gas.
    Type: Application
    Filed: November 24, 2023
    Publication date: May 23, 2024
    Inventors: Agata Exner, Felipe Matias Berg, Eric Abenojar
  • TARGETED NANOBUBBLE THERAPY
    Publication number: 20230092885
    Abstract: A method of inducing cell death in a subject includes administering to the subject a plurality of cell targeted nanobubbles that are internalized by the target cell and insonating nanobubbles internalized into the target cell with ultrasound energy effective to promote inertial cavitation of the internalized nanobubbles and apoptosis and/or necrosis of the target cell.
    Type: Application
    Filed: March 12, 2021
    Publication date: March 23, 2023
    Inventors: AGATA EXNER, JAMES BASILION, AMIN JAFARI SOJARHOOD, AL DELEON, RESHANI PERERA, MICHAEL KOLIOS
  • STABILIZED NANOBUBBLES AND MICROBUBBLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATION
    Publication number: 20210106699
    Abstract: A composition includes a plurality of stabilized nanobubbles and/or microbubbles. Each nanobubble and/or microbubble has a lipid membrane that defines at least one internal void, which includes at least one gas, the membrane including a plurality of lipids, an edge-activator, which is incorporated between lipids of the membrane and enhances the flexibility of the nanobubbles and/or microbubbles, and a membrane stiffener, which is incorporated on an outer surface of the membrane and enhances the membranes resistance to tearing.
    Type: Application
    Filed: March 29, 2019
    Publication date: April 15, 2021
    Inventors: Agata Exner, Al de Leon, Reshani PERERA, Pinunta Tayacharn
  • Stabilized nanobubbles for diagnostic and therapeutic applications
    Patent number: 10973935
    Abstract: A stabilized nanobubble can include a membrane that defines at least one internal void, which includes at least one gas. The membrane can include at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: April 13, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Agata Exner, Tianyi Krupka, Luis Solorio
  • STABILIZED NANOBUBBLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20200061220
    Abstract: A stabilized nanobubble can include a membrane that defines at least one internal void, which includes at least one gas. The membrane can include at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Application
    Filed: July 23, 2019
    Publication date: February 27, 2020
    Inventors: Agata Exner, Tianyi Krupka, Luis Solorio
  • PSMA targeted nanobubbles for diagnostic and therapeutic applications
    Patent number: 10434194
    Abstract: A PSMA targeted nanobubble includes a membrane that defines at least one internal void, which includes at least one gas, and at least one PSMA ligand coupled or conjugated to the membrane. The membrane includes at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: October 8, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: James R. Basilion, Agata Exner, Xinning Wang, Christopher Hernandez
  • Stabilized nanobubbles for diagnostic and therapeutic applications
    Patent number: 10357575
    Abstract: A stabilized nanobubble can include a membrane that defines at least one internal void, which includes at least one gas. The membrane can include at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: July 23, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Agata Exner, Tianyi Krupka, Luis Solorio
  • STABILIZED CROSSLINKED NANOBUBBLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20190175766
    Abstract: A composition includes a plurality of stabilized crosslinked nanobubbles, each nanobubble having a membrane that defines at least one internal void, which includes at least one gas, the membrane including at least one lipid, at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble, and an interpenetrating crosslinked biodegradable polymer.
    Type: Application
    Filed: June 2, 2017
    Publication date: June 13, 2019
    Inventors: Agata Exner, Reshani Perera, Chris Hernandez
  • PSMA TARGETED NANOBUBBLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20180064831
    Abstract: A PSMA targeted nanobubble includes a membrane that defines at least one internal void, which includes at least one gas, and at least one PSMA ligand coupled or conjugated to the membrane. The membrane includes at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Application
    Filed: August 30, 2017
    Publication date: March 8, 2018
    Inventors: James R. Basilion, Agata Exner
  • Method for treating a neoplastic disorder
    Patent number: 9320757
    Abstract: A method for treating a neoplastic disorder in a subject includes administering to the neoplastic cells a neoplastic cell-sensitizing composition including a poly(ethylene oxide)-poly(propylene oxide) copolymer. The poly(ethylene oxide)-poly(propylene oxide) copolymer can sensitize the neoplastic cells to hyperthermia. Energy can be applied to the neoplastic cells to heat and ablate the cells.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: April 26, 2016
    Assignee: Case Western Reserve University
    Inventors: Agata Exner, Tianyi Krupka, Brent Weinberg, John Haaga
  • TOXICITY ENHANCING COMPOUNDS AND METHODS
    Publication number: 20160000824
    Abstract: A method of treating a tumor or cancer in a subject includes administering to cancer or tumor cells of the subject a radiation sensitizing amount of a poly(ethylene oxide)-poly(propylene oxide) copolymer and administering radiation therapy to the cancer or tumor cells sensitized by the poly(ethylene oxide)-poly(propylene oxide) copolymer.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Inventors: Agata Exner, Bryan J. Traughber, Tianyi Krupka, Reshani Perera, David Dremann
  • Toxicity enhancing compounds and methods
    Patent number: 9132149
    Abstract: A method of treating a tumor or cancer in a subject includes administering to cancer or tumor cells of the subject a radiation sensitizing amount of a poly(ethylene oxide)-poly(propylene oxide) copolymer and administering radiation therapy to the cancer or tumor cells sensitized by the poly(ethylene oxide)-poly(propylene oxide) copolymer.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: September 15, 2015
    Assignee: Case Western Reserve University
    Inventors: Agata Exner, Bryan J. Traughber, Tianyi Krupka, Reshani Perera, David Dremann
  • STABILIZED NANOBUBBLES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20140147390
    Abstract: A stabilized nanobubble can include a membrane that defines at least one internal void, which includes at least one gas. The membrane can include at least one lipid and at least one nonionic triblock copolymer that is effective to control the size of the nanobubble without compromising in vitro and in vivo echogenicity of the nanobubble.
    Type: Application
    Filed: September 26, 2011
    Publication date: May 29, 2014
    Inventors: Agata Exner, Tianyi Krupka, Luis Solorio
  • TOXICITY ENHANCING COMPOUNDS AND METHODS
    Publication number: 20120225027
    Abstract: A method of treating a tumor or cancer in a subject includes administering to cancer or tumor cells of the subject a radiation sensitizing amount of a poly(ethylene oxide)-poly(propylene oxide) copolymer and administering radiation therapy to the cancer or tumor cells sensitized by the poly(ethylene oxide)-poly(propylene oxide) copolymer.
    Type: Application
    Filed: March 8, 2012
    Publication date: September 6, 2012
    Inventors: Agata Exner, Bryan J. Traughber, Tianyi Krupka, Reshani Perera, David Dremann
  • METHOD OF DETECTING ABNORMAL TISSUE
    Publication number: 20100080757
    Abstract: A method for detecting abnormal biological tissue includes administering a vasoactive agent and determining the rate of blood flow in a tissue of interest.
    Type: Application
    Filed: February 8, 2006
    Publication date: April 1, 2010
    Inventors: John R. Haaga, Nicholas Stowe, Agata A. Exner
  • METHOD FOR TREATING A NEOPLASTIC DISORDER
    Publication number: 20080206187
    Abstract: A method for treating a neoplastic disorder in a subject includes administering to the neoplastic cells a neoplastic cell-sensitizing composition including a poly(ethylene oxide)-poly(propylene oxide) copolymer. The poly(ethylene oxide)-poly(propylene oxide) copolymer can sensitize the neoplastic cells to hyperthermia. Energy can be applied to the neoplastic cells to heat and ablate the cells.
    Type: Application
    Filed: November 29, 2007
    Publication date: August 28, 2008
    Inventors: Agata Exner, Tianyi Krupka, Brent Weinberg, John Haaga
  • Drug delivery devices and methods
    Publication number: 20030118649
    Abstract: The present invention relates to drug delivery devices that provide sustained release of a therapeutic agent upon implantation into a patient. In certain embodiments, the devices provide an initial burst release of an agent, followed by sustained release of that agent, or of a different agent. The devices comprise a central core surrounded at least one membrane or coating.
    Type: Application
    Filed: October 4, 2002
    Publication date: June 26, 2003
    Inventors: Jinming Gao, Feng Qian, Agata Exner, John R. Haaga