Patents by Inventor Aggelos Nikolopoulos

Aggelos Nikolopoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of erythromycin, clarithromycin, roxithromycin or azithromycin with antibiotic and mucolytic activity
    Patent number: 6599885
    Abstract: A pharmaceutical with an enhanced pharmaceutical profile comprises a mucolytic and an antibiotic in which the mucolytic is present in an amount of greater than one molar equivalent of the antibiotic. The antibiotic may be selected from Erythromycin, Roxithromycin, Clarithromycin, Azithromycin, Dirithromycin; and pharmaceutically acceptable salts or esters thereof. The mucolytic is a mucolytically active thiol, especially N-acetylcysteine, mercaptoethanesulfonic acid, tiopronin or methylcysteine. The adducts can be isolated via a simple and efficient process.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: July 29, 2003
    Assignee: Russinsky Limited
    Inventors: Helmut Schickaneder, Aggelos Nikolopoulos, Gesine Hermann
  • Process for the preparation of Aceclofenac
    Publication number: 20030060657
    Abstract: Compounds of the Formula I 1
    Type: Application
    Filed: June 5, 2002
    Publication date: March 27, 2003
    Applicant: Russinsky Limited
    Inventors: Helmut Schickaneder, Aggelos Nikolopoulos, Trevor Murphy
  • Tramadol, salts thereof and process for their preparation
    Patent number: 6469213
    Abstract: Cis-Tramadol hydrochloride is prepared by forming a Mannich hydrochloride, liberating the Mannich base, reacting the Mannich base with a Grignard reagent to form a base hydrate of cis-Tramadol which is used to form pure cis-Tramadol hydrochloride. Also claimed is the base hydrate of cis-Tramadol per se and its use as a medicament.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: October 22, 2002
    Assignee: Russinsky Limited
    Inventors: Helmut Schickaneder, Aggelos Nikolopoulos
  • Derivatives of erythromycin, clarithromycin, roxithromycin or azithromycin with antibiotic and mucolytic activity
    Publication number: 20010031736
    Abstract: A pharmaceutical with an enhanced pharmaceutical profile comprises a mucolytic and an antibiotic in which the mucolytic is present in an amount of greater than one molar equivalent of the antibiotic. The antibiotic may be selected from Erythromycin, Roxithromycin, Clarithromycin, Azithromycin, Dirithromycin; and pharmaceutically acceptable salts or esters thereof. The mucolytic is a mucolytically active thiol, especially N-acetylcysteine, mercaptoethanesulfonic acid, tiopronin or methylcysteine. The adducts can be isolated via a simple and efficient process.
    Type: Application
    Filed: April 19, 2001
    Publication date: October 18, 2001
    Inventors: Helmut Schickaneder, Aggelos Nikolopoulos, Gesine Hermann
  • Process for preparing form 1 ranitidine hydrochloride
    Patent number: 5663381
    Abstract: A process for preparing pure N-[2-[[[5-[dimethylamino)-methyl-2-furanyl]methyl]thio]ethyl]-N'-methyl-2- nitro-1,1-ethyldiamine hydrochloride, designated Form 1 ranitidine hydrochloride, from ranitidine in methylene chloride with the addition of hydrochloric acid. The Form 1 ranitidine hydrochloride thus obtained is stable and therefore useful for producing commercial-scale quantities of Form 1 ranitidine hydrochloride.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: September 2, 1997
    Assignee: Hexal Pharmaceuticals, Inc.
    Inventors: Helmut Schickaneder, Aggelos Nikolopoulos