Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: A combined transformer is comprised of a transformer chamber, a low-voltage chamber, a high-voltage chamber and a radiator. There is a hollow thermal pipe filled with a heat-transfer medium in the radiator. One of the ends of the thermal pipe is plugged into the transformer chamber and on being located the other end there are heat sinks. Wherein the low-voltage chamber being located on the transformer and the high-voltage chamber being on the side of the transformer, the transformer chamber and the high-voltage chamber are embedded in the ground. The prefabricated substations are comprised of a transformer chamber, a transformer arranged in the transformer chamber, a switch chamber including a low-voltage chamber and a high-voltage chamber, a radiator and a hollow thermal pipe filled with a heat-transfer medium in the radiator.