Abstract: The use of a Wnt inhibitor Wnt-C59 in the preparation of a drug for treating SCN5A mutation-induced dilated cardiomyopathy (DCM) is provided. With SCN5A genotype detection as a breakthrough point, a Wnt pathway-specific inhibitor Wnt-C59 is used to inhibit the abnormal activation of the Wnt?-Catenin pathway caused by SCN5A gene mutation, thereby improving the prognosis of cardiac function in a patient with SCN5A gene mutation-induced DCM. In experiments, aging and adriamycin-induced DCM models are constructed, and the therapeutic effect of Wnt-C59 on DCM is detected through indexes such as changes in cardiac function and activation of related signal molecules, which provides a theoretical basis for use of Wnt-C59 in the clinical treatment of DCM. A new treatment method for SCN5A mutation-induced DCM is provided to bring dawn to such patients and has promising application prospects.

Abstract: The use of a Wnt inhibitor Wnt-C59 in the preparation of a drug for treating SCN5A mutation-induced dilated cardiomyopathy (DCM) is provided. With SCN5A genotype detection as a breakthrough point, a Wnt pathway-specific inhibitor Wnt-C59 is used to inhibit the abnormal activation of the Wnt?-Catenin pathway caused by SCN5A gene mutation, thereby improving the prognosis of cardiac function in a patient with SCN5A gene mutation-induced DCM. In experiments, aging and adriamycin-induced DCM models are constructed, and the therapeutic effect of Wnt-C59 on DCM is detected through indexes such as changes in cardiac function and activation of related signal molecules, which provides a theoretical basis for use of Wnt-C59 in the clinical treatment of DCM. A new treatment method for SCN5A mutation-induced DCM is provided to bring dawn to such patients and has promising application prospects.

Abstract: The invention discloses a caliper repairing clamp, which relates to the technical field of calipers and comprises a machine body, wherein a polishing disc is arranged inside the machine body, a protective cover is arranged on the outer surface of the polishing disc, a moving table is arranged below the machine body, a polishing table is arranged above the moving table, a fixed table is fixedly connected to the upper surface of the polishing table, a first bearing is fixedly embedded inside the machine body, a rotating handle is arranged below the moving table, and a first threaded rod is fixedly connected to the upper surface of the rotating handle.

Abstract: The invention discloses a caliper repairing clamp, which relates to the technical field of calipers and comprises a machine body, wherein a polishing disc is arranged inside the machine body, a protective cover is arranged on the outer surface of the polishing disc, a moving table is arranged below the machine body, a polishing table is arranged above the moving table, a fixed table is fixedly connected to the upper surface of the polishing table, a first bearing is fixedly embedded inside the machine body, a rotating handle is arranged below the moving table, and a first threaded rod is fixedly connected to the upper surface of the rotating handle.

Abstract: The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Non-invasive methods for assessing tumor perfusion and oxidative metabolism for in vivo imaging with PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and evaluation of salivary gland function are provided. A pharmaceutical comprising the PET tracer and a kit for the preparation of the pharmaceutical are provided as well.

Abstract: The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Methods for in vivo imaging uses of the PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and evaluation of salivary gland function are also provided. A pharmaceutical comprising the PET tracer and a kit for the preparation of the pharmaceutical are provided as well.