Patents by Inventor Aileen Milan

Aileen Milan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitrilases, nucleic acids encoding them and methods for making and using them
    Patent number: 9217164
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: December 22, 2015
    Assignee: BASF Enzymes LLC
    Inventors: Jennifer A. Chaplin, Ellen Chi, Grace DeSantis, Mark Madden, Darcy Madden, Aileen Milan, Dan E. Robertson, Jay M. Short, David P. Weiner
  • Nitrilases
    Patent number: 8906663
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: December 9, 2014
    Assignee: Verenium Corporation
    Inventors: David Weiner, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay M. Short, Grace DeSantis, Mark Madden, Mark J. Burk, Dan E. Robertson
  • Nucleic acids encoding nitrilases
    Patent number: 8334125
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: December 18, 2012
    Assignee: Verenium Corporation
    Inventors: Grace DeSantis, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay Short, David Weiner, Mark Madden, Darcy Madden, legal representative, Mark Burk, Dan Robertson
  • GROWTH SELECTION METHOD
    Publication number: 20120010104
    Abstract: The invention provides growth selection methods for screening an environmental or a mixed population library of nucleic acids comprising uncharacterized nucleic acids for the presence of a nucleic acid encoding an enzyme of interest. In one aspect, methods for screening and identification of enzymes, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases are provided. Methods for the production and screening of gene libraries generated from nucleic acids isolated from more than one organism for enzymes of interest, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases, are also provided.
    Type: Application
    Filed: June 21, 2011
    Publication date: January 12, 2012
    Inventors: David Weiner, Tim Hitchman, Lishan Zhao, Mark J. Burk, Grace Desantis, Sarah Richardson Hanson, Aileen Milan, Toby Richardson, Patti Kretz, William Greenberg
  • Nucleic Acids Encoding Nitrilases
    Publication number: 20110263839
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: June 27, 2011
    Publication date: October 27, 2011
    Applicant: VERENIUM CORPORATION
    Inventors: Grace DESANTIS, Jennifer Ann CHAPLIN, Ellen CHI, Aileen MILAN, Jay M. SHORT, David WEINER, Mark MADDEN, Darcy MADDEN, Mark J. BURK, Dan E. ROBERTSON
  • Nitrilases and methods for making and using them
    Patent number: 7993901
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: August 9, 2011
    Assignee: Verenium Corporation
    Inventors: Grace Desantis, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay Short, David Weiner, Mark Madden, Marcy Madden, legal representative, Mark Burk, Dan Robertson
  • Methods for the manufacture of pure single enantiomer compounds and for selecting enantioselective enzymes
    Patent number: 7981844
    Abstract: The invention provides biocatalytic methods for the manufacture of pure single enantiomer compounds. This invention provides methods of screening for enzymes which are highly enantioselective or enzymes that can provide any desired stereoisomer of a compound. The invention provides the use of single enantiomer substrates in performing a growth screen of a clonal library to identify highly stereoselective enzymes. In one aspect, methods for screening and identification of enzymes, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases are provided. Methods for the production and screening of gene libraries generated from nucleic acids isolated from more than one organism for enzyme, e.g., transaminase, activities are also provided.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: July 19, 2011
    Assignee: Verenium Corporation
    Inventors: David Weiner, Tim Hitchman, Lishan Zhao, Mark J. Burk, Grace Desantis, Sarah Richardson Hanson, Aileen Milan, Toby Richardson, Patti Kretz, William Greenberg
  • Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them
    Publication number: 20100273659
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: February 29, 2008
    Publication date: October 28, 2010
    Applicant: VERENIUM CORPORATION
    Inventors: Grace DeSantis, Jennifer Chaplin, Ellen Chi, Aileen Milan, Jay Short, David Weiner, Mark Madden, Darcy Madden, Dan Robertson
  • Nitrilases and Methods for Making and Using Them
    Publication number: 20100086986
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: December 2, 2009
    Publication date: April 8, 2010
    Applicant: VERENIUM CORPORATION
    Inventors: Grace DESANTIS, Jennifer Ann CHAPLIN, Ellen CHI, Aileen MILAN, Jay M. SHORT, David WEINER, Mark MADDEN, Darcy MADDEN, Mark J. BURK, Dan E. ROBERTSON
  • Nitrilases
    Patent number: 7651849
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: January 26, 2010
    Inventors: Grace DeSantis, Ellen Chi, Jennifer Ann Chaplin, Aileen Milan, Jay M. Short, David Paul Weiner, Mark Madden, Darcy Madden, legal representative, Mark J. Burk, Dan E. Robertson
  • NITRILASES
    Publication number: 20090176976
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: March 3, 2009
    Publication date: July 9, 2009
    Inventors: Grace DESANTIS, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Mark Madden, Mark J. Burk, Dan E. Robertson, Darcy Madden
  • Nitrilases and methods for making and using them
    Patent number: 7521216
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: April 21, 2009
    Assignee: Verenium Corporation
    Inventors: Grace DeSantis, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Darcy Madden, legal representative, Mark J. Burk, Dan E. Robertson, Mark Madden
  • Epoxide hydrolases, nucleic acids encoding them and methods of making and using them
    Patent number: 6979733
    Abstract: The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: December 27, 2005
    Assignee: Diversa Corporation
    Inventors: Lishan Zhao, Eric J. Mathur, David Weiner, Toby Richardson, Aileen Milan, Mark J. Burk, Bin Han, Jay M. Short
  • Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
    Patent number: 6943001
    Abstract: The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: September 13, 2005
    Assignee: Diversa Corporation
    Inventors: Lishan Zhao, Eric J. Mathur, David Weiner, Toby Richardson, Aileen Milan, Mark J. Burk, Bin Han, Jay M. Short
  • Assays and kits for detecting the presence of nitriles and/or cyanide
    Publication number: 20040038419
    Abstract: In one aspect, invention relates to the field of monitoring chemical reactions and, in one aspect, provides methods and kits for detecting the presence of nitrites and/or cyanide. In one aspect, the invention provides methods and kits for assaying catalytic activity of a material, such as an enzyme, in a chemical or biochemical process, or assaying catalytic activity of a material in a biological sample, such as a whole cell.
    Type: Application
    Filed: May 15, 2003
    Publication date: February 26, 2004
    Applicant: Diversa Corporation
    Inventors: David Paul Weiner, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Grace DeSantis, Mark J. Burk, Jeffrey McQuaid, Justin Stege
  • Nitrilases
    Publication number: 20040002147
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: September 9, 2002
    Publication date: January 1, 2004
    Inventors: Grace Desantis, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Mark J. Burk, Eric J. Mathur, Darcy Madden (Heir)
  • Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
    Publication number: 20030148490
    Abstract: The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
    Type: Application
    Filed: October 10, 2002
    Publication date: August 7, 2003
    Inventors: Lishan Zhao, Eric J. Mathur, David Weiner, Toby Richardson, Aileen Milan, Mark J. Burk, Bin Han, Jay M. Short
  • Epoxide hydrolases, nucleic acids encoding them and methods of making and using them
    Publication number: 20030148443
    Abstract: The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
    Type: Application
    Filed: August 5, 2002
    Publication date: August 7, 2003
    Inventors: Lishan Zhao, Eric J. Mathur, David Weiner, Toby Richardson, Aileen Milan, Mark J. Burk, Bin Han, Jay M. Short
  • Nitrilases
    Publication number: 20030124698
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: May 15, 2002
    Publication date: July 3, 2003
    Applicant: DIVERSA Corporation
    Inventors: Grace DeSantis, Jennifer Ann Chaplin, Ellen Chi, Aileen Milan, Jay M. Short, David Weiner, Mark Maddes, Darcy Madden, Mark J. Burk, Eric Mathur
  • Methods for the Manufacture of pure single enantiomer compounds and for selecting enantioselective enzymes
    Publication number: 20030092033
    Abstract: The invention provides biocatalytic methods for the manufacture of pure single enantiomer compounds. This invention provides methods of screening for enzymes which are highly enantioselective or enzymes that can provide any desired stereoisomer of a compound. The invention provides the use of single enantiomer substrates in performing a growth screen of a clonal library to identify highly stereoselective enzymes.
    Type: Application
    Filed: June 21, 2002
    Publication date: May 15, 2003
    Inventors: David Weiner, Tim Hitchman, Lishan Zhao, Mark J. Burk, Grace Desantis, Sarah Richardson Hanson, Aileen Milan, Toby Richardson, Patti Kretz, Willaiam Greenberg