Patents by Inventor Akifumi Matsuyama
Akifumi Matsuyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20210338741Abstract: The present invention provides a method of tissue healing in a subject involving administering to the subject a pharmaceutical composition for healing tissue. The pharmaceutical composition contains: adherent cells originating from mesenchymal tissue that has been treated with a physiologically active polypeptide or an LPS; and a pharmaceutically acceptable carrier.Type: ApplicationFiled: July 15, 2021Publication date: November 4, 2021Applicants: OSAKA AIR MACHINE SERVICE, LTD., Regene Pharm Co., Ltd.Inventors: Akifumi MATSUYAMA, Hanayuki OKURA
-
Publication number: 20210244766Abstract: The present invention provides a pharmaceutical composition for healing tissue, said pharmaceutical composition comprising adherent cells originating from mesenchymal tissue treated with a physiologically active polypeptide or an LPS, or culture supernatant thereof, and a pharmaceutically acceptable carrier, and a method for producing the pharmaceutical composition.Type: ApplicationFiled: June 17, 2019Publication date: August 12, 2021Applicants: OSAKA AIR MACHINE SERVICE, LTD., Regene Pharm Co., Ltd.Inventors: Akifumi MATSUYAMA, Hanayuki OKURA
-
Publication number: 20200085881Abstract: The present invention provides a pharmaceutical composition for healing tissue, said pharmaceutical composition containing: adherent cells originating from mesenchymal tissue that has been treated with a physiologically active polypeptide or an LPS; and a pharmaceutically acceptable carrier.Type: ApplicationFiled: December 15, 2017Publication date: March 19, 2020Applicants: OSAKA AIR MACHINE SERVICE, LTD., Regene Pharm Co., Ltd.Inventors: Akifumi MATSUYAMA, Hanayuki OKURA
-
Publication number: 20180100141Abstract: Disclosed is a cell mass containing an adipose-tissue-derived multipotent progenitor cell. Also disclosed is a method for producing an adipose-tissue-derived multipotent progenitor cell from an adipose tissue, which comprises the steps of: (a) removing erythrocytes from an adipose-tissue-derived cell mass to produce a preadipose-tissue-derived multipotent progenitor cell mass; and (b) removing cells other than the adipose-tissue-derived multipotent progenitor cell from the preadipose-tissue-derived multipotent progenitor cell mass to produce the desired adipose-tissue-derived multipotent progenitor cell. Further disclosed is an adipose-tissue-derived multipotent progenitor cell produced by the method.Type: ApplicationFiled: November 30, 2017Publication date: April 12, 2018Inventor: Akifumi MATSUYAMA
-
Publication number: 20180072994Abstract: Disclosed is a cell mass containing an adipose-tissue-derived multipotent progenitor cell. Also disclosed is a method for producing an adipose-tissue-derived multipotent progenitor cell from an adipose tissue, which comprises the steps of: (a) removing erythrocytes from an adipose-tissue-derived cell mass to produce a preadipose-tissue-derived multipotent progenitor cell mass; and (b) removing cells other than the adipose-tissue-derived multipotent progenitor cell from the preadipose-tissue-derived multipotent progenitor cell mass to produce the desired adipose-tissue-derived multipotent progenitor cell. Further disclosed is an adipose-tissue-derived multipotent progenitor cell produced by the method.Type: ApplicationFiled: November 29, 2017Publication date: March 15, 2018Inventor: Akifumi MATSUYAMA
-
Patent number: 9845458Abstract: Disclosed is a cell mass containing an adipose-tissue-derived multipotent progenitor cell. Also disclosed is a method for producing an adipose-tissue-derived multipotent progenitor cell from an adipose tissue, which comprises the steps of: (a) removing erythrocytes from an adipose-tissue-derived cell mass to produce a preadipose-tissue-derived multipotent progenitor cell mass; and (b) removing cells other than the adipose-tissue-derived multipotent progenitor cell from the preadipose-tissue-derived multipotent progenitor cell mass to produce the desired adipose-tissue-derived multipotent progenitor cell. Further disclosed is an adipose-tissue-derived multipotent progenitor cell produced by the method.Type: GrantFiled: June 16, 2008Date of Patent: December 19, 2017Inventors: Akifumi Matsuyama, Hiroshi Komoda, Hanayuki Ohkura, Yoshiki Sawa
-
Patent number: 9644181Abstract: The present invention relates to a method for producing a cell population comprising myocardium-committed cells that differentiate into and survive as myocardial cells under a myocardial tissue environment. Specifically, the method is characterized in that adipose-tissue-derived multi-lineage/multi-potent progenitor cells are cultured in the presence of a polyamine. The present invention further relates to a cell population comprising the myocardium-committed cells, a cell preparation comprising the cell population, or a cell sheet. The present invention further relates to a method for treating a heart disease, which comprises administering the cell population to a subject.Type: GrantFiled: April 25, 2013Date of Patent: May 9, 2017Assignees: RIKENInventors: Akifumi Matsuyama, Hanayuki Okura
-
Publication number: 20160312188Abstract: A method of obtaining pancreatic endocrine cells from cells originating in an adipose tissue characterized by comprising culturing the adipose tissue-origin cells; the pancreatic endocrine cells that can be obtained thereby; a method of treating or preventing a disease caused by the hypofunction in pancreatic endocrine cells wherein the above-described pancreatic endocrine cells are used; a method of screening a substance capable of promoting or inhibiting the differentiation into pancreatic endocrine cells characterized by comprising adding a candidate substance to a medium in the course of culturing adipose tissue-origin cells to obtain the pancreatic endocrine cells; and so on.Type: ApplicationFiled: January 8, 2016Publication date: October 27, 2016Inventors: Akifumi Matsuyama, Hiroshi Komoda, Yoshiki Sawa, Yuzuru Kanakura
-
Patent number: 9428733Abstract: A method of obtaining pancreatic endocrine cells from cells originating in an adipose tissue characterized by comprising culturing the adipose tissue-origin cells; the pancreatic endocrine cells that can be obtained thereby; a method of treating or preventing a disease caused by the hypofunction in pancreatic endocrine cells wherein the above-described pancreatic endocrine cells are used; a method of screening a substance capable of promoting or inhibiting the differentiation into pancreatic endocrine cells characterized by comprising adding a candidate substance to a medium in the course of culturing adipose tissue-origin cells to obtain the pancreatic endocrine cells; and so on.Type: GrantFiled: June 15, 2012Date of Patent: August 30, 2016Assignee: AKIFUMI MATSUYAMAInventors: Akifumi Matsuyama, Hiroshi Komoda, Yoshiki Sawa, Yuzuru Kanakura
-
Publication number: 20150291934Abstract: The present invention relates to a method for producing a cell population comprising myocardium-committed cells that differentiate into and survive as myocardial cells under a myocardial tissue environment. Specifically, the method is characterized in that adipose-tissue-derived multi-lineage/multi-potent progenitor cells are cultured in the presence of a polyamine. The present invention further relates to a cell population comprising the myocardium-committed cells, a cell preparation comprising the cell population, or a cell sheet. The present invention further relates to a method for treating a heart disease, which comprises administering the cell population to a subject.Type: ApplicationFiled: April 25, 2013Publication date: October 15, 2015Applicants: RIKEN, Akifumi MatsuyamaInventors: Akifumi Matsuyama, Hanayuki Okura
-
Patent number: 8784803Abstract: The present invention relates to a therapeutic agent for liver-related diseases, comprising adipose tissue-derived multilineage progenitor cells; and others.Type: GrantFiled: August 27, 2010Date of Patent: July 22, 2014Assignee: Osaka Air Machine Service, Ltd.Inventor: Akifumi Matsuyama
-
Publication number: 20130109092Abstract: A method of obtaining pancreatic endocrine cells from cells originating in an adipose tissue characterized by comprising culturing the adipose tissue-origin cells; the pancreatic endocrine cells that can be obtained thereby; a method of treating or preventing a disease caused by the hypofunction in pancreatic endocrine cells wherein the above-described pancreatic endocrine cells are used; a method of screening a substance capable of promoting or inhibiting the differentiation into pancreatic endocrine cells characterized by comprising adding a candidate substance to a medium in the course of culturing adipose tissue-origin cells to obtain the pancreatic endocrine cells; and so on.Type: ApplicationFiled: June 15, 2012Publication date: May 2, 2013Applicant: OSAKA UNIVERSITYInventors: Akifumi Matsuyama, Hiroshi Komoda, Yoshiki Sawa, Yuzuru Kanakura
-
Publication number: 20130101659Abstract: Provided are a cell sheet and a three-dimensional structure thereof that include at least mesenchymal stem cells and myoblasts isolated from a cell culture support and that are to be applied to heart disease. Use of the cell sheet and the three-dimensional structure thereof including mesenchymal stem cells and myoblasts can notably improve cardiac functions compared with a conventional technology, i.e., use of cell sheets composed of myoblasts only or mesenchymal stem cells only. Furthermore, the cell sheet itself has high strength, and the transplantation procedure is also improved.Type: ApplicationFiled: September 9, 2010Publication date: April 25, 2013Inventors: Yoshiki Sawa, Yasuhiro Shudo, Shigeru Miyagawa, Tatsuya Shimizu, Teruo Okano, Akifumi Matsuyama, Atsuhiro Saito
-
Publication number: 20120156181Abstract: The present invention relates to a therapeutic agent for liver-related diseases, comprising adipose tissue-derived multilineage progenitor cells; and others.Type: ApplicationFiled: August 27, 2010Publication date: June 21, 2012Applicant: FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATIONInventor: Akifumi Matsuyama
-
Publication number: 20100322906Abstract: A method of obtaining pancreatic endocrine cells from cells originating in an adipose tissue characterized by comprising culturing the adipose tissue-origin cells; the pancreatic endocrine cells that can be obtained thereby; a method of treating or preventing a disease caused by the hypofunction in pancreatic endocrine cells wherein the above-described pancreatic endocrine cells are used; a method of screening a substance capable of promoting or inhibiting the differentiation into pancreatic endocrine cells characterized by comprising adding a candidate substance to a medium in the course of culturing adipose tissue-origin cells to obtain the pancreatic endocrine cells; and so on.Type: ApplicationFiled: August 14, 2006Publication date: December 23, 2010Applicant: Osaka UniversityInventors: Akifumi Matsuyama, Hiroshi Komoda, Yoshiki Sawa, Yuzuru Kanakura
-
Publication number: 20100183568Abstract: Disclosed are: a method for producing a hepatic-lobule-like cell mass from an adipose-tissue-derived cell, which is characterized by culturing the adipose-tissue-derived cell; a hepatic-lobule-like cell mass produced by the method; a method for the screening of a substance capable of promoting or inhibiting the formation of a hepatic-lobule-like cell mass, which is characterized by culturing an adipose-tissue-derived cell to produce the hepatic-lobule-like cell mass, wherein a candidate substance is added to a culture medium; and a kit for use in the screening method.Type: ApplicationFiled: June 16, 2008Publication date: July 22, 2010Applicant: FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATIONInventors: Akifumi Matsuyama, Hiroshi Komoda, Yoshiki Sawa
-
Publication number: 20100151574Abstract: Disclosed is a cell mass containing an adipose-tissue-derived multipotent progenitor cell. Also disclosed is a method for producing an adipose-tissue-derived multipotent progenitor cell from an adipose tissue, which comprises the steps of: (a) removing erythrocytes from an adipose-tissue-derived cell mass to produce a preadipose-tissue-derived multipotent progenitor cell mass; and (b) removing cells other than the adipose-tissue-derived multipotent progenitor cell from the preadipose-tissue-derived multipotent progenitor cell mass to produce the desired adipose-tissue-derived multipotent progenitor cell. Further disclosed is an adipose-tissue-derived multipotent progenitor cell produced by the method.Type: ApplicationFiled: June 16, 2008Publication date: June 17, 2010Applicant: FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATIONInventors: Akifumi Matsuyama, Hiroshi Komoda, Hanayuki Ohkura, Yoshiki Sawa
-
Publication number: 20100068188Abstract: An object of the present invention is to provide technology of using a preadipocyte to restore comprehensively bone, cartilage and periodontal ligament, and cause a periodontal hard tissue to regenerate. By culturing a preadipocyte using a culture medium containing (i) at least one member selected from the group consisting of glycerophosphate and salts thereof, and (ii) at least one member selected from the group consisting of ascorbic acid, derivatives thereof and salts thereof and not containing an adrenal cortical hormone in such an amount that promotes differentiation of a preadipocyte into a periodontal hard tissue cell, differentiation of the cell into a periodontal hard tissue cell is induced efficiently. Furthermore, a scaffold is combined with the preadipocyte cultured with the above-mentioned culture medium to be transplanted into a periodontal tissue that requires regeneration.Type: ApplicationFiled: September 20, 2007Publication date: March 18, 2010Inventors: Shinya Murakami, Tomoko Hashikawa, Yoshiki Sawa, Akifumi Matsuyama, Hiroshi Komoda