Patents by Inventor Akihiro KUNISAWA
Akihiro KUNISAWA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240053306Abstract: Provided is a quantitative determination method for sulfur compounds in a target group selected from a plurality of groups, e.g., a group including cysteine and related reactive sulfurs, including the steps of: performing an LC/MS/MS measurement of a standard substance having a known concentration of a base compound, e.g.Type: ApplicationFiled: August 4, 2023Publication date: February 15, 2024Applicants: SHIMADZU CORPORATION, Shimadzu Techno-Research, Inc.Inventors: Akihiro KUNISAWA, Atsuhiko TOYAMA, Takaaki AKAIKE, Tsubasa IBUSHI
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Patent number: 11486866Abstract: When chromatogram data for a target sample have been acquired, a peak position estimator determines an estimated result of the position of the starting and/or ending point of a peak as well as the confidence value representing the reliability of the estimation, using a trained model stored in the trained model storage section. Normally, a plurality of estimated results of the starting point and/or ending point of the peak are acquired for one peak. A peak information correction processor identifies a candidate having the highest confidence as a prime candidate, and superposes a plurality of candidates including the prime candidate, with their respective confidence values, on a displayed chromatogram. An operator referring to the confidence values selects a peak which needs close checking or correction, and corrects the starting point and/or ending point of the selected peak, for example, by selecting and indicating a candidate other than the prime candidate.Type: GrantFiled: November 9, 2017Date of Patent: November 1, 2022Assignee: SHIMADZU CORPORATIONInventors: Takeshi Osoekawa, Yusuke Hida, Yuzi Kanazawa, Shinji Kanazawa, Yohei Yamada, Hiroyuki Yasuda, Akihiro Kunisawa
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Publication number: 20220196615Abstract: An analyzer configured to acquire a chromatogram or spectrum by performing a predetermined analysis of a sample and perform a qualitative or quantitative analysis of components contained in the sample. The analyzer includes: a peak detection unit configured, based on information regarding a plurality of target components that need to be checked whether contained in the sample or that need to be quantified, to detect a peak or peaks in the chromatogram or spectrum acquired by the predetermined analysis of the sample corresponding to one of the target components, configured to acquire peak information regarding each of the peak or peaks, and configured to obtain confidence information for each of the peak or peaks, the confidence information being an indicative value of certainty of detecting a peak; and a display processing unit configured to display on a display unit a list of at least a part of the target components.Type: ApplicationFiled: May 8, 2019Publication date: June 23, 2022Applicants: SHIMADZU CORPORATION, FUJITSU LIMITEDInventors: Yohei YAMADA, Shinji KANAZAWA, Hiroyuki YASUDA, Akihiro KUNISAWA, Yuzi KANAZAWA, Yusuke HIDA
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Patent number: 11302039Abstract: A model constructed by a training process using the technique of deep learning using the training data including images created from a large number of chromatograms and correct peak information is previously stored in a trained model storage section. When chromatogram data for a target sample acquired with an LC measurement unit are inputted, an image creator converts the chromatogram into an image and creates an input image in which one of the two areas divided by the chromatogram curve as the boundary in the image is filled. A peak position estimator inputs the pixel values of the input image into a trained model using a neural network, and obtains the position information of the starting point and/or ending point of the peak and a peak detection confidence as the output. A peak determiner determines the starting point and/or ending point of each peak based on the peak detection confidence.Type: GrantFiled: November 9, 2017Date of Patent: April 12, 2022Assignee: SHIMADZU CORPORATIONInventors: Takeshi Osoekawa, Yusuke Hida, Yuzi Kanazawa, Shinji Kanazawa, Yohei Yamada, Hiroyuki Yasuda, Akihiro Kunisawa, Hidetoshi Terada
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Patent number: 11285458Abstract: A separating medium for hydrophilic interaction chromatography useful in separating hydrophilic compounds. The hydrophilic interaction chromatography separating medium, which is formed from a support and a ligand carried by the support, is a separating medium wherein the ligand is a (meth)acrylic polymer having a constituent unit derived from the compound indicated by formula (I).Type: GrantFiled: July 8, 2014Date of Patent: March 29, 2022Assignees: NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY, DAICEL CORPORATIONInventors: Tohru Ikegami, Yusuke Kawachi, Akihiro Kunisawa
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Publication number: 20200292509Abstract: When chromatogram data for a target sample have been acquired, a peak position estimator determines an estimated result of the position of the starting and/or ending point of a peak as well as the confidence value representing the reliability of the estimation, using a trained model stored in the trained model storage section. Normally, a plurality of estimated results of the starting point and/or ending point of the peak are acquired for one peak. A peak information correction processor identifies a candidate having the highest confidence as a prime candidate, and superposes a plurality of candidates including the prime candidate, with their respective confidence values, on a displayed chromatogram. An operator referring to the confidence values selects a peak which needs close checking or correction, and corrects the starting point and/or ending point of the selected peak, for example, by selecting and indicating a candidate other than the prime candidate.Type: ApplicationFiled: November 9, 2017Publication date: September 17, 2020Applicant: SHIMADZU CORPORATIONInventors: Takeshi OSOEKAWA, Yusuke HIDA, Yuzi KANAZAWA, Shinji KANAZAWA, Yohei YAMADA, Hiroyuki YASUDA, Akihiro KUNISAWA
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Publication number: 20200279408Abstract: A model constructed by a training process using the technique of deep learning using the training data including images created from a large number of chromatograms and correct peak information is previously stored in a trained model storage section. When chromatogram data for a target sample acquired with an LC measurement unit are inputted, an image creator converts the chromatogram into an image and creates an input image in which one of the two areas divided by the chromatogram curve as the boundary in the image is filled. A peak position estimator inputs the pixel values of the input image into a trained model using a neural network, and obtains the position information of the starting point and/or ending point of the peak and a peak detection confidence as the output. A peak determiner determines the starting point and/or ending point of each peak based on the peak detection confidence.Type: ApplicationFiled: November 9, 2017Publication date: September 3, 2020Applicant: SHIMADZU CORPORATIONInventors: Takeshi OSOEKAWA, Yusuke HIDA, Yuzi KANAZAWA, Shinji KANAZAWA, Yohei YAMADA, Hiroyuki YASUDA, Akihiro KUNISAWA, Hidetoshi TERADA
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Publication number: 20160168302Abstract: The problem addressed by the present invention is to provide a novel separating medium for hydrophilic interaction chromatography useful in separating hydrophilic compounds. The hydrophilic interaction chromatography separating medium, which is formed from a support and a ligand carried by the support, is a separating medium wherein the ligand is a (meth)acrylic polymer having a constituent unit derived from the compound indicated by formula (I).Type: ApplicationFiled: July 8, 2014Publication date: June 16, 2016Inventors: Tohru IKEGAMI, Yusuke KAWACHI, Akihiro KUNISAWA