Patents by Inventor Akihiro Nagaya
Akihiro Nagaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11993629Abstract: The invention provides a method for producing a peptide which comprises the following steps (1) and (2): (1) a step of condensing a C-protected amino acid or a C-protected peptide to a C-terminal of an N-protected amino acid or an N-protected peptide represented by the formula (I): wherein Y represents an amino acid in which a C-terminal is unprotected or a peptide in which a C-terminal is unprotected, R1, R2 and R3 each independently represent an aliphatic hydrocarbon group which may have a substituent(s), a total number of the carbon atoms in the R1R2R3Si group is 10 or more, and the R1R2R3SiOC(O) group is bonded to the N-terminal in Y, and (2) a step of removing the protective group at the C-terminal of the peptide obtained in step (1).Type: GrantFiled: February 3, 2020Date of Patent: May 28, 2024Assignees: Nissan Chemical Corporation, PeptiDream Inc.Inventors: Michiharu Handa, Naohiko Yasuda, Akihiro Nagaya, Hiroyuki Kousaka
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Publication number: 20220306682Abstract: The invention provides a method for producing a peptide by (1) removing the N-terminal protective group of an amino acid or peptide compound of formula (I): wherein Y represents a residue of an N-protected amino acid or an N-protected peptide, and each of R1, R2, and R3 independently represents an aliphatic hydrocarbon group which may have a substituent or an aromatic hydrocarbon group which may have a substituent, wherein the total number of carbon atoms in the R1R2R3Si group is 18 to 80, and the R1R2R3SiCH2CH2 group is bonded to the C-terminus of the amino acid or peptide residue in Y; and (2) causing condensation of an N-protected amino acid or an N-protected peptide and the N-terminus of the C-protected amino acid or C-protected peptide obtained in the step (1).Type: ApplicationFiled: August 27, 2020Publication date: September 29, 2022Applicant: NISSAN CHEMICAL CORPORATIONInventors: Akihiro NAGAYA, Michiharu HANDA, Yuji MIMORI
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Publication number: 20220220133Abstract: The invention provides a method for producing a triorganosilane compound which includes (1) a step of reacting a diorganosilane compound represented by the formula (I): with a triflating reagent to obtain a monotriflate compound represented by the formula (III): and (2) a step of reacting the monotriflate compound obtained in the step (1) with a metal reagent represented by R3Li or R3MgX to obtain a triorganosilane compound represented by the formula (II): wherein R1, R2 and R3 are as defined herein.Type: ApplicationFiled: April 23, 2020Publication date: July 14, 2022Applicant: NISSAN CHEMICAL CORPORATIONInventors: Madoka YOSHINO, Kazuya WAKUI, Akihiro NAGAYA
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Publication number: 20220153777Abstract: The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).Type: ApplicationFiled: March 16, 2020Publication date: May 19, 2022Applicants: NISSAN CHEMICAL CORPORATION, PeptiDream Inc.Inventors: Hisayuki TAKEUCHI, Yukio ASAKA, Akihiro NAGAYA, Michiharu HANDA, Keiichi MASUYA, Tomonori TAGURI, Yoshitaka NEMOTO, Yutaka KOBAYASHI, Ayumu MATSUDA, Haruaki KURASAKI, Douglas Robert CARY
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Publication number: 20220106355Abstract: The invention provides a method for producing a peptide which comprises the following steps (1) and (2): (1) a step of condensing a C-protected amino acid or a C-protected peptide to a C-terminal of an N-protected amino acid or an N-protected peptide represented by the formula (I): wherein Y represents an amino acid in which a C-terminal is unprotected or a peptide in which a C-terminal is unprotected, R1, R2 and R3 each independently represent an aliphatic hydrocarbon group which may have a substituent(s), a total number of the carbon atoms in the R1R2R3Si group is 10 or more, and the R1R2R3SiOC(O) group is bonded to the N-terminal in Y, and (2) a step of removing the protective group at the C-terminal of the peptide obtained in step (1).Type: ApplicationFiled: February 3, 2020Publication date: April 7, 2022Applicants: NISSAN CHEMICAL CORPORATION, PeptiDream Inc.Inventors: Michiharu HANDA, Naohiko YASUDA, Akihiro NAGAYA, Hiroyuki KOUSAKA
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Publication number: 20200291061Abstract: A method for producing a peptide by conducting steps (1) condensing an N-protected amino acid or an N-protected peptide to an N-terminus of a C-protected amino acid or a C-protected peptide represented by formula (II): wherein Y represents an amino acid or a peptide with an unprotected N-terminus; R1, R2 and R3 each independently represent an optionally substituted aliphatic hydrocarbon group, an optionally substituted aromatic hydrocarbon group, or —OR4 (wherein R4 represents an optionally substituted aliphatic or aromatic hydrocarbon group; two of R1, R2 and R3 may form a 5- to 7-membered ring together with the Si atom to which they are bonded; and the R1R2R3Si group has 8 or more carbon atoms and is bonded to a C-terminus of an amino acid or a peptide in Y, and (2) removing the protective group at the N-terminus of the peptide obtained in step (1).Type: ApplicationFiled: October 3, 2018Publication date: September 17, 2020Applicants: NISSAN CHEMICAL CORPORATION, PeptiDream Inc.Inventors: Akihiro NAGAYA, Michiharu HANDA, Naohiko YASUDA, Madoka YOSHINO, Yutaka KOBAYASHI, Keiichi MASUYA
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Publication number: 20170267659Abstract: To provide a method for producing a compound represented by the formula (1) which is a 2-pyridone compound useful as a pharmaceutical or an intermediate for a pharmaceutical, etc. at a high yield.Type: ApplicationFiled: May 11, 2015Publication date: September 21, 2017Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Hironobu YOSHINO, Yasuhiro UMEDA, Jun TAKEOKA, Akihiro NAGAYA, Yudai SUGAWARA, Madoka YOSHINO
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Patent number: 9464095Abstract: A method for producing a high-purity nitrogen-containing heterocyclic compound includes: a process (a) and a process (b): (a) a process of mixing a mixture containing a compound and as an impurity compound with a solvent and a metal salt, and (b) a process of obtaining a mixture in a solution state in which the content of the compound has decreased compared to that in the mixture in the process (a) by filtering a mixed solution obtained in the process (a), or a process of obtaining a mixture in which the content of the compound has decreased compared to that in the mixture in the process (a) by further evaporating the solvent or crystallizing following the filtering; (where R1 and R2 are each independently a hydrogen atom, a C1-6 alkyl group, etc., R3 is a hydrogen atom, a C1-6 alkyl group, etc., X is a hydrogen atom, etc.).Type: GrantFiled: September 27, 2013Date of Patent: October 11, 2016Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Hirohide Kitsuyama, Akihiro Nagaya, Hironobu Yoshino, Ikumasa Hidaka
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Publication number: 20160168161Abstract: There is provided a method for producing with a high efficiency a heterocyclic compound that is useful as a raw material for pharamaceuticals. A novel production method for producing 2,2,7,9-tetramethyl-2H-pyrano[2,3-g]quinoline (compound (6)) that has a quinoline ring and a chromene ring using N-(3-acetyl-4-hydroxyphenyl)butylamide (compound (1?)) that is commercially available as a raw material for pharamaceuticals or the like as a starting raw material; and a method for purifying compound (6), characterized by purifying by subjecting it to conversion into a salt form.Type: ApplicationFiled: July 22, 2014Publication date: June 16, 2016Applicant: NISSAN CHEMICAL INDUSTIES, LTD.Inventors: Akihiro NAGAYA, Madoka YOSHINO, Hironobu YOSHINO
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Publication number: 20150239899Abstract: A method for producing a high-purity nitrogen-containing heterocyclic compound includes: a process (a) and a process (b): (a) a process of mixing a mixture containing a compound and as an impurity compound with a solvent and a metal salt, and (b) a process of obtaining a mixture in a solution state in which the content of the compound has decreased compared to that in the mixture in the process (a) by filtering a mixed solution obtained in the process (a), or a process of obtaining a mixture in which the content of the compound has decreased compared to that in the mixture in the process (a) by further evaporating the solvent or crystallizing following the filtering; (where R1 and R2 are each independently a hydrogen atom, a C1-6 alkyl group, etc., R3 is a hydrogen atom, a C1-6 alkyl group, etc., X is a hydrogen atom, etc.Type: ApplicationFiled: September 27, 2013Publication date: August 27, 2015Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Hirohide Kitsuyama, Akihiro Nagaya, Hironobu Yoshino, Ikumasa Hidaka
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Publication number: 20020009354Abstract: A cable assembler which makes it possible to carry out in a short tact time the assembling of cable terminal which needs a plurality of jigs and tools. A robot delivers a bobbin of cable to various stations in a working area. Processing in accordance with the invention reduces tact time.Type: ApplicationFiled: June 5, 2001Publication date: January 24, 2002Inventors: Akihiro Nagaya, Yasushi Nishi, Morishisa Ishizawa
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Patent number: D491842Type: GrantFiled: May 20, 2003Date of Patent: June 22, 2004Inventors: Machio Nakamura, Kenji Kido, Naoki Hamajima, Akihiro Nagaya