Patents by Inventor Akiko Kuramochi
Akiko Kuramochi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8697369Abstract: Using betaKlotho or a substance that increases or inhibits betaKlotho activity as an agent for controlling the activity of FGF21 mediated by an FGF receptor, the present invention provides a pharmaceutical composition comprising such betaKlotho or such substance as an active ingredient, particularly, a pharmaceutical composition for anti-metabolic syndrome, and further particularly, a pharmaceutical composition for therapeutic or preventive use associated with the control of blood glucose level. In addition, the present invention provides a screening system for each of a substance that enhances or suppresses betaKlotho activity, an FGF21-like active substance, and a betaKlotho-like active substance, which uses a cell system that has expressed an FGF receptor and/or betaKlotho on the surface thereof.Type: GrantFiled: April 7, 2008Date of Patent: April 15, 2014Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Masashi Suzuki, Toru Imamura, Yuriko Uehara, Kaori Motomura, Junko Oki, Syuichi Oka, Masahiro Asada, Akiko Kuramochi, Miho Kimura
-
Publication number: 20120251455Abstract: A hair removing agent or a hair growth inhibiting agent is provided by determining an endogenous factor having a hair growth inhibitory activity, screening for substances having an activity similar to that of the endogenous factor or substances enhancing the activity or expression of the endogenous factor, and utilizing the physiological activities of such substances. It has been found that FGF18 inhibits hair growth. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. Also disclosed is a hair growth inhibiting agent or a hair removing agent comprising, as an active ingredient, FGF18 and/or an FGF18 partial peptide, or an FGF18-like active substance and/or a substance that promotes the activity or expression of FGF18 (e.g., Digenea simplex extract).Type: ApplicationFiled: January 27, 2012Publication date: October 4, 2012Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Toru IMAMURA, Miho KIMURA, Mitsuko KAWANO, Nozomi TSUJINO, Akiko KURAMOCHI, Yuko ODA, Kaori MOTOMURA, Masashi SUZUKI, Masahiro ASADA, Azusa KAMEYAMA, Sumie TOGAYACHI, Syuichi OKA
-
Publication number: 20120214740Abstract: There is provided an FGF2 substitute-containing medicinal composition which comprises, as an active ingredient, a chimeric protein comprising the amino acid sequence of an FGF1 protein in which a partial sequence including a sequence of at least positions 62-83 within a sequence of positions 41-83 is substituted with a partial sequence at the corresponding positions in the amino acid sequence of an FGF2 protein; and the remaining region is formed of the amino acid sequence of FGF1. In particular, this medicinal composition is used for wound healing and for the prevention and treatment of radiation-induced damage, and it exhibits a pharmacological action superior to that of an FGF2 medicinal composition, and further, it can be easily formulated into a preparation.Type: ApplicationFiled: April 4, 2012Publication date: August 23, 2012Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Toru IMAMURA, Kaori MOTOMURA, Akiko KURAMOCHI, Yoshiro HANYU, Masashi SUZUKI, Masahiro ASADA, Akiko HAGIWARA, Fumiaki NAKAYAMA, Makoto AKASHI
-
Publication number: 20100286042Abstract: There is provided an FGF2 substitute containing medicinal composition which comprises, as an active ingredient, a chimeric protein comprising the amino acid sequence of an FGF1 protein in which a partial sequence including a sequence of at least positions 62-83 within a sequence of positions 41-83 is substituted with a partial sequence at the corresponding positions in the amino acid sequence of an FGF2 protein; and the remaining region is formed of the amino acid sequence of FGF1. In particular, this medicinal composition is used for wound healing and for the prevention and treatment of radiation-induced damage, and it exhibits a pharmacological action superior to that of an FGF2 medicinal composition, and further, it can be easily formulated into a preparation.Type: ApplicationFiled: October 10, 2008Publication date: November 11, 2010Applicant: National Institute of advanced Industrial Science and TechnologyInventors: Toru Imamura, Kaori Motomura, Akiko Kuramochi, Yoshiro Hanyu, Masashi Suzuki, Masahiro Asada, Akiko Hagiwara, Fumiaki Nakayama, Makoto Akashi
-
Publication number: 20100203055Abstract: It is intended to provide a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia by determining an endogenous factor that inhibits hair growth and screening for substances that inhibit the activity or expression of the endogenous factor. It has been found that FGF18 inhibits hair growth. A method of screening for substances that inhibit the activity of FGF18 or substances that inhibit the expression of FGF18 to thereby obtain candidates for the hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia is disclosed. Also disclosed is a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia comprising, as an active ingredient(s), a substance that inhibit the activity of FGF18 and/or a substance that inhibits the expression of FGF18 such as a partial peptide of FGF18 or a Momordica charantia hot water extract.Type: ApplicationFiled: February 19, 2008Publication date: August 12, 2010Inventors: Toru Imamura, Miho Kimura, Mitsuko Kawano, Nozomi Tsujino, Akiko Kuramochi, Yuko Oda, Kaori Motomura, Masashi Suzuki, Masahiro Asada, Azusa Kameyama, Sumie Togayachi, Syuichi Oka
-
Publication number: 20100184665Abstract: Using betaKlotho or a substance that increases or inhibits betaKlotho activity as an agent for controlling the activity of FGF21 mediated by an FGF receptor, the present invention provides a pharmaceutical composition comprising such betaKlotho or such substance as an active ingredient, particularly, a pharmaceutical composition for anti-metabolic syndrome, and further particularly, a pharmaceutical composition for therapeutic or preventive use associated with the control of blood glucose level. In addition, the present invention provides a screening system for each of a substance that enhances or suppresses betaKlotho activity, an FGF21-like active substance, and a betaKlotho-like active substance, which uses a cell system that has expressed an FGF receptor and/or betaKlotho on the surface thereof.Type: ApplicationFiled: April 7, 2008Publication date: July 22, 2010Inventors: Masashi Suzuki, Toru Imamura, Yuriko Uehara, Kaori Motomura, Junko Oki, Syuichi Oka, Masahiro Asada, Akiko Kuramochi, Miho Kimura
-
Publication number: 20100183733Abstract: A hair removing agent or a hair growth inhibiting agent is provided by determining an endogenous factor having a hair growth inhibitory activity, screening for substances having an activity similar to that of the endogenous factor or substances enhancing the activity or expression of the endogenous factor, and utilizing the physiological activities of such substances. It has been found that FGF18 inhibits hair growth. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. Also disclosed is a hair growth inhibiting agent or a hair removing agent comprising, as an active ingredient, FGF18 and/or an FGF18 partial peptide, or an FGF18-like active substance and/or a substance that promotes the activity or expression of FGF18 (e.g., Digenea simplex extract).Type: ApplicationFiled: February 19, 2008Publication date: July 22, 2010Inventors: Toru Imamura, Miho Kimura, Mitsuko Kawano, Nazomi Tsujino, Akiko Kuramochi, Yuko Oda, Kaori Motomura, Masashi Suzuki, Masahiro Asada, Azusa Kameyama, Sumie Togayachi, Syuichi Oka
-
Patent number: 7589060Abstract: It is intended to elucidate the effect of promoting hair follicle growth and to provide the following therapeutic agents for hair-related problems (1) to (3): (1) a hair growth promoting agent, comprising as an active ingredient an expression vector incorporating a full-length FGF-18, a partial peptide thereof, or a cDNA encoding the full-length FGF-18 or the partial peptide; (2) a hair regrowth promoting agent, comprising as an active ingredient an expression vector incorporating a full-length FGF-18, a partial peptide thereof, or a cDNA encoding the full-length FGF-18 or the partial peptide; and (3) a therapeutic agent for alopecia, comprising as an active ingredient an expression vector incorporating a full-length FGF-18, a partial peptide thereof, or a cDNA encoding the full-length FGF-18 or the partial peptide.Type: GrantFiled: September 8, 2005Date of Patent: September 15, 2009Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Toru Imamura, Mitsuko Kawano, Akiko Kuramochi, Masashi Suzuki, Masahiro Asada
-
Publication number: 20080139469Abstract: It is intended to elucidate the effect of promoting hair follicle growth and to provide the following therapeutic agents for hair-related problems (1) to (3): (1) a hair growth promoting agent, comprising as an active ingredient an expression vector incorporating a full-length FGF-18, a partial peptide thereof, or a cDNA encoding the full-length FGF-18 or the partial peptide; (2) a hair regrowth promoting agent, comprising as an active ingredient an expression vector incorporating a full-length FGF-18, a partial peptide thereof, or a cDNA encoding the full-length FGF-18 or the partial peptide; and (3) a therapeutic agent for alopecia, comprising as an active ingredient an expression vector incorporating a full-length FGF-18, a partial peptide thereof, or a cDNA encoding the full-length FGF-18 or the partial peptide.Type: ApplicationFiled: September 8, 2005Publication date: June 12, 2008Inventors: Toru Imamura, Mitsuko Kawano, Akiko Kuramochi, Masashi Suzuki, Masahiro Asada
-
Patent number: 6624146Abstract: The present invention relates to a pharmaceutical composition comprising, as an active ingredient, a peptide represented by the following formula (I): MTS-X-NLS (I) wherein MTS represents a membrane-transfer amino acid sequence; X represents a direct bond or a linker sequence; and NLS represents a nuclear localization amino acid sequence, or a pharmaceutically acceptable salt thereof, particularly, a pharmaceutical composition having food and water intake inhibitory effects, and accompanying weight-reducing and obesity-inhibiting effects.Type: GrantFiled: April 4, 2001Date of Patent: September 23, 2003Assignee: Agency of Industrial Science and TechnologyInventors: Toru Imamura, Ai-Jun Li, Akiko Kuramochi, Hiroyuki Tsuboyama