Patents by Inventor Akiko Sano

Akiko Sano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complex chromosome engineering for production of human antibodies in transgenic animals
    Patent number: 9902970
    Abstract: The invention relates to large-scale production of human antibodies by transgenic animals with high production of fully human IgG up to >10 g/L in sera with human IgG1 subclass dominancy. This invention also supports a feasibility of complex chromosome engineering for complicated genetic studies in non-murine mammalian species.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: February 27, 2018
    Assignee: SAB, LLC
    Inventors: Yoshimi Kuroiwa, Hiroaki Matsushita, Akiko Sano
  • Human artificial chromosome vector
    Patent number: 9315824
    Abstract: The present invention provides a human artificial chromosome vector comprising a gene encoding the human antibody heavy chain, a gene encoding the human antibody light chain, and a gene encoding IgM heavy chain constant region derived from a nonhuman animal; and being capable of producing a human antibody with a higher efficiency when the vector is introduced into an animal. By immunizing the animal produced using a human artificial chromosome vector of the present invention with a desired antigen, a large quantity of human polyclonal antibodies can be supplied.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: April 19, 2016
    Assignee: SAB, LLC
    Inventors: Yoshimi Kuroiwa, Hiroaki Matsushita, Akiko Sano
  • COMPLEX CHROMOSOME ENGINEERING FOR PRODUCTION OF HUMAN ANTIBODIES IN TRANSGENIC ANIMALS
    Publication number: 20150211020
    Abstract: The invention relates to large-scale production of human antibodies by transgenic animals with high production of fully human IgG up to >10 g/L in sera with human IgG1 subclass dominancy. This invention also supports a feasibility of complex chromosome engineering for complicated genetic studies in non-murine mammalian species.
    Type: Application
    Filed: August 5, 2013
    Publication date: July 30, 2015
    Inventors: Yoshimi Kuroiwa, Hiroaki Matsushita, Akiko Sano
  • HUMAN ARTIFICIAL CHROMOSOME VECTOR
    Publication number: 20120233715
    Abstract: A human artificial chromosome vector comprising a human antibody heavy chain gene, a human antibody light chain gene, and a human antibody surrogate light chain gene.
    Type: Application
    Filed: November 17, 2010
    Publication date: September 13, 2012
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yoshimi Kuroiwa, Hiroaki Matsushita, Akiko Sano
  • HUMAN ARTIFICIAL CHROMOSOME VECTOR
    Publication number: 20120222140
    Abstract: The present invention provides a human artificial chromosome vector comprising a gene encoding the human antibody heavy chain, a gene encoding the human antibody light chain, and a gene encoding IgM heavy chain constant region derived from a nonhuman animal; and being capable of producing a human antibody with a higher efficiency when the vector is introduced into an animal. By immunizing the animal produced using a human artificial chromosome vector of the present invention with a desired antigen, a large quantity of human polyclonal antibodies can be supplied.
    Type: Application
    Filed: November 17, 2010
    Publication date: August 30, 2012
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Yoshimi Kuroiwa, Hiroaki Matsushita, Akiko Sano