Abstract: A coolant supply mechanism is attachable to a cutting insert. The cutting insert has a first bottom surface, a first upper surface, and a first side surface. The first upper surface includes a corner portion that is located at a corner of the first upper surface when viewed in a plan view and that is contiguous to the first side surface so as to form a cutting edge, and a center portion located adjacent to the corner portion on a side opposite to the cutting edge when viewed in a plan view. The first upper surface is depressed toward the first bottom surface side at the center portion.

Abstract: A joined product according to the present invention is a joined product including a cemented carbide sintered compact serving as a first material to be joined and a cBN sintered compact or a diamond sintered compact serving as a second material to be joined. The first material to be joined and the second material to be joined are joined by a joining material that forms a liquid phase at a temperature exceeding 800° C. and lower than 1000° C. and that is placed between the first material to be joined and the second material to be joined. The first material to be joined and the second material to be joined are joined by resistance heating and pressing at a pressure of 0.1 to 200 MPa.

Abstract: An adsorbent for cardiac glycoside contained in body fluid, comprising a compound having a log P value of at least 6 immobilized on a water-insoluble carrier is provided. A process for adsorbing and removing cardiac glycoside contained in body fluid efficiently, which comprises contacting body fluid with this adsorbent for cardiac glycoside is provided.

Abstract: The present invention relates to a novel protein (MAY-I) which exhibits immunosuppressive activity in allogeneic mixed lymphocyte reaction, and provides a gene encoding that protein, a vector containing said gene, a transformant produced by said vector, a method of manufacturing the said protein with immune activity by culturing said transformant, and a medicinal composition and the like containing the said protein.

Abstract: The present invention relates to a novel protein (MAY-I) which exhibits immunosuppressive activity in allogeneic mixed lymphocyte reaction, and provides a gene encoding that protein, a vector containing said gene, a transformant produced by said vector, a method of manufacturing the said protein with immune activity by culturing said transformant, and a medicinal composition and the like containing the said protein.

Abstract: It is an object of the present invention to provide a protein having a drug transport activity, a method for screening a compound that promotes or inhibits the activity of the drug transporter, a compound obtained by the method, an antibody against the drug transporter, a pharmaceutical composition comprising the same, or the like. The protein with a drug transport activity of the present invention has an amino acid sequence represented by SEQ ID NO: 1.

Abstract: An adsorbent for cardiac glycoside contained in body fluid, comprising a compound having a log P value of at least 6 immobilized on a water-insoluble carrier is provided. A process for adsorbing and removing cardiac glycoside contained in body fluid efficiently, which comprises contacting body fluid with this adsorbent for cardiac glycoside is provided.

Abstract: A method for the production of a glass substrate for magnetic recording mediums is herein provided and this method is characterized in that the final cleaning step is performed in two stages, in which scrubbing and dip-cleaning steps are carried out after the completion of the first cleaning stage and after the growth of needle-like projections comprising an alkali metal carbonate on the surface of the glass substrate. The method for the production of a glass substrate for magnetic recording mediums does not require the use of an expensive device having high resistance to acids. Moreover, in the glass substrate for magnetic recording mediums produced by the foregoing method, any growth of needle-like projections containing an alkali metal carbonate on the surface of the glass substrate is inhibited even during temporal storage of the substrate.

Abstract: A method for the production of a glass substrate for magnetic recording mediums comprises the steps of sandwiching an abrasion board for correction between upper and lower surface tables of a both side-polishing device for polishing the glass substrate, while these upper and lower surface tables are fitted to the polishing device, rotating the upper and lower surface tables in the opposite directions while supplying cooling water to thus polish the surface of these tables to a flatness of the table surface on the order of not more than 30 &mgr;m; then adhering abrasion cloths to the upper and lower surface tables, respectively; thereafter repeatedly polishing the surface of the glass substrate for magnetic recording mediums. The production method permits the efficient production of an excellent glass substrate for magnetic recording mediums.

Abstract: A method for preparing a glass substrate for use in making a magnetic recording medium is herein disclosed and the method is characterized in that an abrasive liquid containing a CeO2-base abrasive having an average particle size, D50, of not more than 0.5 &mgr;m in an amount of not more than 1% by mass and an abrasive cloth are used in a step for final polishing the glass substrate for magnetic recording media. The method permits easy preparation of a glass substrate for use in making a magnetic recording medium, which has a uniform surface, is substantially free of any surface defect and has a smooth surface having an extremely low surface roughness.

Abstract: A method for the production of a glass substrate for magnetic recording mediums comprises the steps of sandwiching an abrasion board for correction between upper and lower surface tables of a both side-polishing device for polishing the glass substrate, while these upper and lower surface tables are fitted to the polishing device, rotating the upper and lower surface tables in the opposite directions while supplying cooling water to thus polish the surface of these tables to a flatness of the table surface on the order of not more than 30 &mgr;m; then adhering abrasion cloths to the upper and lower surface tables, respectively; thereafter repeatedly polishing the surface of the glass substrate for magnetic recording mediums. The production method permits the efficient production of an excellent glass substrate for magnetic recording mediums.

Abstract: A method for the production of a glass substrate for magnetic recording mediums is herein provided and this method is characterized in that the final cleaning step is performed in two stages, in which scrubbing and dip-cleaning steps are carried out after the completion of the first cleaning stage and after the growth of needle-like projections comprising an alkali metal carbonate on the surface of the glass substrate. The method for the production of a glass substrate for magnetic recording mediums does not require the use of an expensive device having high resistance to acids. Moreover, in the glass substrate for magnetic recording mediums produced by the foregoing method, any growth of needle-like projections containing an alkali metal carbonate on the surface of the glass substrate is inhibited even during temporal storage of the substrate.

Abstract: A method for the production of a glass substrate for magnetic recording mediums comprises disk-processing, grinding, polishing and cleaning steps and the method is characterized in that the grinding step is carried out using a cooling liquid and a both side-grinding device for grinding a glass substrate for magnetic recording mediums, in which thin plate-like nonferrous metal-bonded grinding wheels, resin-bonded grinding wheels or vitrified bonded grinding wheels, containing abrasive grains are adhered to the surfaces of the upper and lower surface tables of the device. The method for the production of a glass substrate for magnetic recording mediums permits the easy and efficient production of a glass substrate for magnetic recording mediums, the method does not require the use of any multistage cleaning stage under the application of ultrasonics and any acid-cleaning stage and it can thus eliminate the possibility of any contamination.