Patents by Inventor Akira Shibuya
Akira Shibuya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240052143Abstract: The present invention relates to a polychloroprene latex composition, a dip-molded product, a pressure-sensitive adhesive, an adhesive, and an adhesive product. The polychloroprene latex composition contains a chloroprene (co)polymer (A) and an aromatic compound (B) having 7 to 10 carbon atoms, and the polychloroprene latex composition has a proportion of the aromatic compound (B) having 7 to 10 carbon atoms of 0.0012 to 0.15 parts by mass based on 100 parts by mass of solid content of the polychloroprene latex composition.Type: ApplicationFiled: December 28, 2021Publication date: February 15, 2024Applicant: RESONAC CORPORATIONInventors: Noriko OGAWA, Akira SHIBUYA
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Publication number: 20230407060Abstract: The present invention relates to a chloroprene copolymer latex, a chloroprene copolymer latex composition, a chloroprene copolymer rubber molded article, a dip-molded product, and a method for producing a chloroprene copolymer latex. The method for producing a chloroprene copolymer latex has a step of emulsion polymerizing 2-chloro-1,3-butadiene (A-1) and 2-methyl-1,3-butadiene (A-2) in the presence of sulfur (A-3).Type: ApplicationFiled: November 9, 2021Publication date: December 21, 2023Applicant: Resonac CorporationInventors: Shu KANEKO, Masahiro OGAWA, Noriko OGAWA, Akira SHIBUYA
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Publication number: 20230212284Abstract: An object is to elucidate the immune response mechanism of IL-17-producing cells which causes a pathological condition such as psoriasis, and to provide an immune response suppressant for suppressing the immune response of IL-17-producing cells, a medicament for treating or preventing a disease or a pathological condition involving the immune response of an IL-17-producing cell, a method for inducing immune response in ??T cells, and a method for evaluating a medicament (candidate substance) and a method for producing IL-17 by use of the method.Type: ApplicationFiled: October 22, 2020Publication date: July 6, 2023Inventors: Kazuko Shibuya, Akira Shibuya, Kyoko Hayashi
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Publication number: 20220340659Abstract: The present invention relates to: an activity modulator which is a means for modulating the activity of CD300b-dependent phagocytosis; and medicine for the treatment or prevention of a disease or condition in which the activity is involved. The activity modulator comprises a CD300a-binding substance and modulates CD300b-dependent phagocytosis signals in a macrophage.Type: ApplicationFiled: May 11, 2022Publication date: October 27, 2022Inventors: Akira Shibuya, Chigusa Oda, Fumie Abe, Satoshi Fujiyama
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Patent number: 11453648Abstract: Provided is a method for producing an orotic acid derivative, the method comprising a condensation step of performing, under a basic condition, a condensation reaction between an orotic acid halide represented by General Formula (I) and a compound represented by General Formula (II) to generate an orotic acid derivative represented by General Formula (III); and a neutralization crystallization step of precipitating crystals of orotic acid by neutralization crystallization to separate a liquid containing the orotic acid derivative from the crystals of orotic acid, after the condensation step. In General Formula (I), (II), or (III), X is a halogen atom, and A is a group represented by General Formula (A-1) or (A-2). In General Formula (A-1) or (A-2), R1 is a hydrogen atom or an organic group, and R2 and R3 are each independently an organic group. In a case where R1 is an organic group, R1 and R2 may be bonded to each other to form a ring.Type: GrantFiled: November 7, 2019Date of Patent: September 27, 2022Assignee: SHOWA DENKO K.K.Inventors: Motoki Murai, Akira Shibuya
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Publication number: 20220242987Abstract: The present invention relates to a chloroprene copolymer latex composition, a molded article of chloroprene copolymer rubber, or a dip-molded product, and the chloroprene copolymer latex composition includes a chloroprene copolymer (A) and a vulcanization accelerator (B). The chloroprene copolymer (A) includes monomer units derived from chloroprene and from 2-methyl-1,3-butadiene. The chloroprene copolymer latex composition includes a carbamate-based vulcanization accelerator and a thiazole-based vulcanization accelerator as the vulcanization accelerator (B). The chloroprene copolymer latex composition enables production of a molded article having high flexibility and high tensile strength without use of a vulcanization accelerator that is feared to have skin sensitization.Type: ApplicationFiled: December 24, 2020Publication date: August 4, 2022Applicant: SHOWA DENKO K.K.Inventors: Shu KANEKO, Masahiro OGAWA, Akira SHIBUYA
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Publication number: 20220243101Abstract: There is provided an adhesive agent exhibiting high adhesive strength to polyolefin. An adhesive agent contains a chloroprene copolymer latex containing a chloroprene copolymer (A) and a metal oxide (B). The chloroprene copolymer (A) is a copolymer of a monomer group containing chloroprene (A-1), ?,?-unsaturated carboxylic acid (A-2), and 2,3-dichloro-1,3-butadiene (A-3). The chloroprene copolymer (A) has a tetrahydrofuran-soluble component soluble in tetrahydrofuran and the weight average molecular weight of the tetrahydrofuran-soluble component is 80000 or more and 140000 or less. When the amount of the metal oxide (B) based on 100 parts by mass of the chloroprene copolymer (A) is defined as Y part(s) by mass and the weight average molecular weight of the tetrahydrofuran-soluble component is defined as X, the content of the metal oxide (B) satisfies Formula: ?1.2×X/100000+1.6<Y<?4.2×X/100000+5.7.Type: ApplicationFiled: May 15, 2020Publication date: August 4, 2022Applicant: SHOWA DENKO K.K.Inventors: Naoki SEKIOKA, Akira SHIBUYA, Noriko OGAWA, Ryo MAKIO
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Publication number: 20220227976Abstract: One embodiment of the present invention relates to a chloroprene copolymer latex, a method for producing a chloroprene copolymer latex, a chloroprene copolymer latex composition, and a molded article or dipped product of a chloroprene copolymer rubber. The chloroprene copolymer latex is a latex of a chloroprene copolymer including monomer units derived from 2-chloro-1,3-butadiene (chloroprene) and monomer units derived from 2-methyl-1,3-butadiene, wherein the tetrahydrofuran insoluble content in the chloroprene copolymer is 20% by mass or less, and the proportion of the monomer units derived from 2-methyl-1,3-butadiene is 10 to 27 mol % in the chloroprene copolymer.Type: ApplicationFiled: October 23, 2020Publication date: July 21, 2022Applicant: SHOWA DENKO K.K.Inventors: Shu KANEKO, Masahiro OGAWA, Akira SHIBUYA
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Patent number: 11358927Abstract: A method of producing an N,N-disubstituted amide of the present invention is a method of reacting a nitrile with an alcohol in the presence of a catalyst, wherein the nitrile is a compound represented by R1CN (R1 represents an alkyl group having 10 or less carbon atoms or an aryl group having 10 or less carbon atoms), wherein the alcohol is a compound represented by R2OH (R2 represents an alkyl group having 10 or less carbon atoms), wherein the catalyst is a metal salt represented by MXn (M represents a metal cation having an oxidation number of n, X represents a monovalent anion including a substituted sulfonyl group represented by —S(?O)2—R3 (R3 represents a hydrocarbon group having 10 or less carbon atoms or a group in which some or all of hydrogen atoms in the hydrocarbon group are substituted with fluorine atoms), and n represents an integer of 1 to 4), a substituent bonded to a carbon atom in a carbonyl group of the N,N-disubstituted amide is R1, and two substituents bonded to nitrogen atoms in an amideType: GrantFiled: April 25, 2019Date of Patent: June 14, 2022Assignee: SHOWA DENKO K.K.Inventors: Yasuyuki Ueda, Akira Shibuya, Hideo Miyata, Hiroshi Uchida
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Publication number: 20220153806Abstract: The present invention provides a composition and method for treating an allergic disease. The composition comprises a ligand for asialoglycoprotein receptor 1 (Asgr1). The allergic disease may be atopic dermatitis, allergic rhinitis, urticaria, allergic asthma, allergic conjunctivitis, allergic gastrointestinal inflammation, or anaphylactic shock. The allergic disease may be caused by house dust mites. The present invention also provides a method for determining if a test compound activates human Asgr1.Type: ApplicationFiled: February 28, 2020Publication date: May 19, 2022Applicant: UNIVERSITY OF TSUKUBAInventors: Akira SHIBUYA, Kazumasa KANEMARU
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Patent number: 11319278Abstract: Provided is a method for producing glycine, in which on synthesizing glycine from glycinonitrile, glycine can be obtained in a higher yield than that in the conventional method. The present invention relates to a method for producing glycine, including allowing glycinonitrile and water to react with each other in the presence of a cerium compound, optionally adding ammonia thereto, to obtain glycine.Type: GrantFiled: July 11, 2017Date of Patent: May 3, 2022Assignee: SHOWA DENKO K.K.Inventors: Takanori Aoki, Akira Shibuya, Takamitsu Kobayashi, Hideo Miyata, Shinya Tsukamoto, Manabu Kuwajima, Motoki Murai
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Publication number: 20220002253Abstract: Provided is a method for producing an orotic acid derivative, the method comprising a condensation step of performing, under a basic condition, a condensation reaction between an orotic acid halide represented by General Formula (I) and a compound represented by General Formula (II) to generate an orotic acid derivative represented by General Formula (III); and a neutralization crystallization step of precipitating crystals of orotic acid by neutralization crystallization to separate a liquid containing the orotic acid derivative from the crystals of orotic acid, after the condensation step. In General Formula (I), (II), or (III), X is a halogen atom, and A is a group represented by General Formula (A-1) or (A-2). In General Formula (A-1) or (A-2), R1 is a hydrogen atom or an organic group, and R2 and R3 are each independently an organic group. In a case where R1 is an organic group, R1 and R2 may be bonded to each other to form a ring.Type: ApplicationFiled: November 7, 2019Publication date: January 6, 2022Applicant: SHOWA DENKO K.K.Inventors: Motoki MURAI, Akira SHIBUYA
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Publication number: 20210292273Abstract: Provided is a method for producing glycine, in which on synthesizing glycine from glycinonitrile, glycine can be obtained in a higher yield than that in the conventional method. The present invention relates to a method for producing glycine, including allowing glycinonitrile and water to react with each other in the presence of a cerium compound, optionally adding ammonia thereto, to obtain glycine.Type: ApplicationFiled: July 11, 2017Publication date: September 23, 2021Applicant: SHOWA DENKO K.K.Inventors: Takanori AOKI, Akira SHIBUYA, Takamitsu KOBAYASHI, Hideo MIYATA, Shinya TSUKAMOTO, Manabu KUWAJIMA, Motoki MURAI
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Publication number: 20210238123Abstract: A method of producing an N,N-disubstituted amide of the present invention is a method of reacting a nitrile with an alcohol in the presence of a catalyst, wherein the nitrile is a compound represented by R1CN (R1 represents an alkyl group having 10 or less carbon atoms or an aryl group having 10 or less carbon atoms), wherein the alcohol is a compound represented by R2OH (R2 represents an alkyl group having 10 or less carbon atoms), wherein the catalyst is a metal salt represented by MXn (M represents a metal cation having an oxidation number of n, X represents a monovalent anion including a substituted sulfonyl group represented by —S(?O)2—R3 (R3 represents a hydrocarbon group having 10 or less carbon atoms or a group in which some or all of hydrogen atoms in the hydrocarbon group are substituted with fluorine atoms), and n represents an integer of 1 to 4), a substituent bonded to a carbon atom in a carbonyl group of the N,N-disubstituted amide is R1, and two substituents bonded to nitrogen atoms in an amideType: ApplicationFiled: April 25, 2019Publication date: August 5, 2021Applicant: SHOWA DENKO K.K.Inventors: Yasuyuki UEDA, Akira SHIBUYA, Hideo MIYATA, Hiroshi UCHIDA
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Patent number: 11059888Abstract: A regulatory T cell activator including a substance that inhibits the binding between DNAX accessory molecule-1 (DNAM-1) and CD155.Type: GrantFiled: April 19, 2017Date of Patent: July 13, 2021Assignee: University of TsukubaInventors: Akira Shibuya, Kazuko Shibuya, Fumie Abe, Rei Hirochika, Genki Okumura
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Publication number: 20210188973Abstract: The present invention relates to: an activity modulator which is a means for modulating the activity of CD300b-dependent phagocytosis; and medicine for the treatment or prevention of a disease or condition in which the activity is involved. The activity modulator comprises a CD300a-binding substance and modulates CD300b-dependent phagocytosis signals in a macrophage.Type: ApplicationFiled: November 28, 2018Publication date: June 24, 2021Inventors: Akira Shibuya, Chigusa Oda, Fumie Abe, Satoshi Fujiyama
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Patent number: 10774037Abstract: The present invention relates to a method for producing a specified ?-amino acid, the method including allowing a specified ?-amino acid amide and water to react with each other in the presence of a zirconium compound which contains zirconium and at least one metal element selected from the group consisting of lithium, nickel, copper, zinc, cesium, barium, hafnium, tantalum, cerium, and dysprosium.Type: GrantFiled: July 25, 2017Date of Patent: September 15, 2020Assignee: SHOWA DENKO K.K.Inventors: Takanori Aoki, Akira Shibuya, Takamitsu Kobayashi, Hideo Miyata, Shinya Tsukamoto, Manabu Kuwajima, Motoki Murai
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Publication number: 20200040077Abstract: The present invention aims to provide: an immunostimulant useful for maintaining, enhancing or suppressing an immune function associated with CD300a activation signaling, or an immunomodulator as an immunosuppressant useful for suppressing the immune function; use of a CD300a gene-deficient mouse for pathology analysis and the like; an anti-CD300a antibody; and the like.Type: ApplicationFiled: October 17, 2019Publication date: February 6, 2020Applicant: UNIVERSITY OF TSUKUBAInventors: Akira Shibuya, Chigusa Oda, Satoko Tahara, Tsukasa Nabekura, Udayanga Sanath Kankanam Gamage, Haruka Miki, Syuichi Iino
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Patent number: 10519233Abstract: The present invention aims to provide: an immunostimulant useful for maintaining, enhancing or suppressing an immune function associated with CD300a activation signaling, or an immunomodulator as an immunosuppressant useful for suppressing the immune function; use of a CD300a gene-deficient mouse for pathology analysis and the like; an anti-CD300a antibody; and the like.Type: GrantFiled: November 7, 2012Date of Patent: December 31, 2019Assignee: UNIVERSITY OF TSUKUBAInventors: Akira Shibuya, Chigusa Oda, Satoko Tahara, Tsukasa Nabekura, Udayanga Sanath Kankanam Gamage, Haruka Miki, Syuichi Iino
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Publication number: 20190161434Abstract: The present invention relates to a method for producing a specified ?-amino acid, the method including allowing a specified ?-amino acid amide and water to react with each other in the presence of a zirconium compound which contains zirconium and at least one metal element selected from the group consisting of lithium, nickel, copper, zinc, cesium, barium, hafnium, tantalum, cerium, and dysprosium.Type: ApplicationFiled: July 25, 2017Publication date: May 30, 2019Applicant: SHOWA DENKO K.K.Inventors: Takanori AOKI, Akira SHIBUYA, Takamitsu KOBAYASHI, Hideo MIYATA, Shinya TSUKAMOTO, Manabu KUWAJIMA, Motoki MURAI