Abstract: This invention is intended to discover a novel solvent that can be used as an alternative to toluene in the step of deprotection in the method of solid-phase nucleic acid synthesis. With the use of such novel solvent, various problems caused by the use of toluene are dissolved. This invention is also intended to provide a method of solid-phase nucleic acid synthesis in which protected nucleoside phosphoramidites in which a protective group is bonded to a hydroxyl group at the 5?position or the 3? position of a nucleoside are sequentially bound on a solid phase carrier, where a reaction of removing the protecting group from the protected nucleoside phosphoramidite is carried out in a solution comprising an acid with a pKa of 0.2 to 0.8 and acetonitrile.

Abstract: This invention is intended to discover a novel solvent that can be used as an alternative to toluene in the step of deprotection in the method of solid-phase nucleic acid synthesis. With the use of such novel solvent, various problems caused by the use of toluene are dissolved. This invention is also intended to provide a method of solid-phase nucleic acid synthesis in which protected nucleoside phosphoramidites in which a protective group is bonded to a hydroxyl group at the 5?position or the 3? position of a nucleoside are sequentially bound on a solid phase carrier, where a reaction of removing the protecting group from the protected nucleoside phosphoramidite is carried out in a solution comprising an acid with a pKa of 0.2 to 0.8 and acetonitrile.

Abstract: An adhesive preparation containing bisoprolol includes a backing and a pressure-sensitive adhesive layer formed on one side of the backing. The pressure-sensitive adhesive layer contains a polymer prepared through copolymerization of monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer (component (A)), a polymer prepared through copolymerization of monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer (component (B)), and bisoprolol (component (C)).

Abstract: An adhesive preparation containing bisoprolol includes a backing and a pressure-sensitive adhesive layer formed on one side of the backing. The pressure-sensitive adhesive layer contains a polymer prepared through copolymerization of monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer (component (A)), a polymer prepared through copolymerization of monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer (component (B)), and bisoprolol (component (C)).

Abstract: A patch preparation includes a support and a pressure-sensitive adhesive layer formed on one surface of the support. The pressure-sensitive adhesive layer includes: (A) a polymer prepared by copolymerizing monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer; (B) a polymer prepared by copolymerizing monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer; and (C) a basic drug, provided that bisoprolol and a salt thereof are excluded.

Abstract: A pattern classification system includes a plurality of classification sections. Each of the classification sections includes a device for storing information of N coefficients W representing a reference pattern, a device for calculating an evaluation value V on the basis of N input signals S and the N coefficients W, the N input signals representing an input pattern, the evaluation value V representing a relation between the input pattern and the reference pattern, a device for storing information of a fixed threshold value R, and a device for comparing the evaluation value V and the threshold value R and for outputting an estimation signal depending on a result of the comparing, the estimation signal including a category signal P which represents a category. A selection section is operative for selecting one of categories in response to the category signals outputted from the classification sections and for outputting a signal Px representing the selected one of the categories.

Abstract: A pattern classification system includes a plurality of classification sections. Each of the classification sections includes a device for storing information of N coefficients W representing a reference pattern, a device for calculating an evaluation value V on the basis of N input signals S and the N coefficients W, the N input signals representing an input pattern, the evaluation value V representing a relation between the input pattern and the reference pattern, a device for storing information of a fixed threshold value R, and a device for comparing the evaluation value V and the threshold value R and for outputting an estimation signal depending on a result of the comparing, the estimation signal including a category signal P which represents a category. A selection section is operative for selecting one of categories in response to the category signals outputted from the classification sections and for outputting a signal Px representing the selected one of the categories.

Abstract: In a temperature control system when can be operated as a heat pump, frost deposited onto an outdoor heat exchanger (evaporator) is detected by a change in temperature of the refrigerant which flows into an indoor heat exchanger (condenser), so that a sensor to detect the deposition of the frost need not be attached to the outdoor heat exchanger. The refrigerant temperature is measured at the inlet of the indoor heat exchanger, and the temperature control system is switched to defrosting operation on the basis of this temperature and various elapsed time periods if the actual heat capability of the incoming refrigerant is insufficient, detecting the temperature of the refrigerant on the inlet side of the indoor heat exchanger, namely, by detecting the temeprature at a single position.