Patents by Inventor Alain Ajamian

Alain Ajamian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
    Patent number: 9636298
    Abstract: The invention relates to prodrugs for use in the inhibition of histone deacetylase. The prodrugs of the present invention have good aqueous solubility and good aqueous stability. The prodrugs of the invention advantageously are metabolized to the active ingredient in plasma or in the blood stream of a warm-blooded animal. The invention also provides compositions and, and methods for making the prodrugs, and methods for using the prodrugs to treat fungal infections.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: May 2, 2017
    Inventors: Alain Ajamian, Yves Andre Chantigny, Arkadii Vaisburg, Franck Raeppel, Stephane Raeppel, Robert Deziel
  • Inhibitors of histone deacetylase
    Patent number: 9096565
    Abstract: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: August 4, 2015
    Assignee: MethylGene Inc.
    Inventors: Pierre Tessier, Silvana Leit, David Smil, Robert Deziel, Alain Ajamian, Yves Andre Chantigny, Celia Dominguez
  • Prodrugs of Compounds that Enhance Antifungal Activity and Compositions of Said Prodrugs
    Publication number: 20150203517
    Abstract: The invention relates to prodrugs for use in the inhibition of histone deacetylase. The prodrugs of the present invention have good aqueous solubility and good aqueous stability. The prodrugs of the invention advantageously are metabolized to the active ingredient in plasma or in the blood stream of a warm-blooded animal. The invention also provides compositions and, and methods for making the prodrugs, and methods for using the prodrugs to treat fungal infections.
    Type: Application
    Filed: January 15, 2015
    Publication date: July 23, 2015
    Inventors: Alain Ajamian, Yves Andre Chantigny, Arkadii Vaisburg, Franck Raeppel, Stephane Raeppel, Robert Deziel
  • Inhibitors of histone deacetylase and prodrugs thereof
    Patent number: 8796330
    Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: August 5, 2014
    Assignee: Methylgene Inc.
    Inventors: Robert Déziel, Alain Ajamian
  • Histone deacetylase inhibitors for enhancing activity of antifungal agents
    Patent number: 8759400
    Abstract: The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, this invention relates to compositions and methods for selectively enhancing fungal sensitivity to antifungal compounds.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: June 24, 2014
    Assignee: MethylGene Inc.
    Inventors: Nafsika Georgopapadakou, Wenqi Hu, Nadia Campeol, Jean Bedard, Robert Deziel, Alain Ajamian
  • Inhibitors of histone deacetylase
    Patent number: 8673911
    Abstract: This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: March 18, 2014
    Assignee: MethylGene Inc.
    Inventors: Tammy Mallais, Oscar Moradei, Alain Ajamian, Pierre Tessier, David Smil, Sylvie Frechette, Silvana Leit, Patrick Beaulieu, Robert Deziel, John Mancuso
  • INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF
    Publication number: 20140024608
    Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 23, 2014
    Applicant: METHYLGENE INC.
    Inventors: Robert Deziel, Alain Ajamian
  • INHIBITORS OF HISTONE DEACETYLASE
    Publication number: 20110021771
    Abstract: This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
    Type: Application
    Filed: November 3, 2008
    Publication date: January 27, 2011
    Applicant: METHYLGENE INC.
    Inventors: Tammy Mallais, Oscar Moradei, Alain Ajamian, Pierre Tessier, David Smil, Sylvie Frechette, Roger Machaalani, Silvana Leit, Patrick Beaulieu, Robert Déziel, John Mancuso
  • Inhibitors of Histone Deacetylase
    Publication number: 20090181943
    Abstract: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
    Type: Application
    Filed: April 9, 2008
    Publication date: July 16, 2009
    Applicant: METHYLGENE INC.
    Inventors: Pierre Tessier, Silvana Leit, David Smil, Robert Deziel, Alain Ajamian, Yves Andre Chantigny, Celia Dominguez
  • INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF
    Publication number: 20080146623
    Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
    Type: Application
    Filed: December 18, 2007
    Publication date: June 19, 2008
    Applicant: METHYLGENE INC.
    Inventors: Robert Deziel, Alain Ajamian
  • SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS
    Publication number: 20070293530
    Abstract: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I), and racemic and scalemic mixtures, diastereomers and enantiomers thereof: or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, prodrug or complex thereof, wherein Y, L, Z, W, M, Ra, Rb and Rc are as defined in the specification.
    Type: Application
    Filed: June 14, 2007
    Publication date: December 20, 2007
    Applicant: METHYLGENE INC.
    Inventors: David Smil, Silvana Leit, Alain Ajamian, Martin Allan, Yves Chantigny, Robert Deziel, Eric Therrien, Amal Wahhab, Sukhdev Manku
  • Histone deacetylase inhibitors for enhancing activity of antifungal agents
    Publication number: 20070197550
    Abstract: The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, this invention relates to compositions and methods for selectively enhancing fungal sensitivity to antifungal compounds.
    Type: Application
    Filed: December 19, 2006
    Publication date: August 23, 2007
    Inventors: Nafsika Georgopapadakou, Wenqi Hu, Nadia Campeol, Jean Bedard, Robert Deziel, Alain Ajamian
  • Inhibitors of histone deacetylase
    Publication number: 20060264415
    Abstract: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Y, L, Z, W, X, Q, R1, R2 and R3 are as defined in the specification.
    Type: Application
    Filed: March 31, 2006
    Publication date: November 23, 2006
    Inventors: Silvana Leit de Moradei, Pierre Tessier, David Smil, Amal Wahhab, Robert Deziel, Sukhdev Manku, John Mancuso, Eric Therrien, Martin Allan, Yves Chantigny, Alain Ajamian, Patrick Beaulieu