Abstract: The device for ionophoresis combines a donor electrode assembly, a counter electrode assembly and a generator of electricity. The donor assembly comprises a primary reservoir element containing the active principle and a secondary reservoir element containing a neutral electrolyte, these reservoir elements being separated by a semipermeable membrane in polymer material in contact with each of them, and an electrode in contact with the secondary reservoir element. The polymer material of the membrane consists at least in polyethyerblocamide with an Mn between 10000 and 300000 and containing by weight, 35% to 90% of polyamide sequences. The invention is applicable to the transcutaneous administration of active principles to a subject with improved efficiency.

Abstract: A device comprising a reversible negative electrode in contact with a reservoir element containing an electrolyte which contains an active principle such as an anionic oligosaccharide, particularly a pentasaccharide, in at least partially ionised form, a positive electrode alone or in combination with an electrolyte-containing receptacle, and an electrical signal generator connectable to both electrodes. The generator is arranged to apply electrical signals between the electrodes, which signals have an average voltage such that the average current density generated between the electrodes is 0.05-0.25 mA/cm.sup.2. The amount of active principle in the reservoir element combined with the negative electrode is 0.5-12 mg per cm.sup.2. The amount of active principle in the reservoir element combined with the negative electrode is 0.5-12 mg per cm.sup.2 and per mAh of current through 1 cm.sup.2 of the electrode.

Abstract: The present invention relates to a method of promoting bone repair in human or veterinary medicine; which method comprises the administration of therapeutically effective amounts of bisphosphonic acid derivatives of formula (I): ##STR1## in which: R.sub.1 is a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono-C.sub.1 -C.sub.4 -alkylamino or a di-C.sub.1 -C.sub.4 -alkylamino; andR.sub.2 is a halogen atom or a linear alkyl containing from 1 to 5 carbon atoms which is unsubstituted or substituted by a group selected from a chlorine atom, a hydroxyl, an amino, a mono-C.sub.1 -C.sub.4 -alkylamino, a di- C.sub.1 -C.sub.4 -alkylamino and a C.sub.3 -C.sub.7 -cycloalkylamino, or R.sub.2 is a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridylmethyl, a 1-pyridyl-1-hydroxymethyl, an imidazolylmethyl or a thiomorpholin-4-yl; and of their salts with pharmaceutically acceptable mineral or organic acids.

Abstract: The invention relates to the cosmetic use of an amino acid copolymer of the statistical formula ##STR1## in which: a and b are each independently 1 or 2;A and B are similar or different and are an amino acid selected from: arginine, serine, proline, glycine, histidine, alanine, lysine, ornithine, citrulline, urocanic acid, asparagine or tyrosine;m, n, p and q are integers such that the ratio (n+q)/(m+p) is between 0.5 and 4; andz is an integer such that the average molecular weight is between 1000 and 100,000; and/or one of its salts.Application: cosmetic products.

Abstract: The invention relates to methylenediphosphonic acid derivatives of the formula: ##STR1## in which: R.sub.1 represents:a C.sub.1 -C.sub.6 alkyl group,a C.sub.5 -C.sub.7 cycloalkyl group,a phenyl group optionally monosubstituted or polysubstituted by a halogen, a C.sub.1 -C.sub.6 alkyl group or a trifluoromethyl group, ora 5-membered or 6-membered heterocycle containing 1 or 2 heteroatoms chosen from nitrogen and sulfur,Alk denotes a linear or branched C.sub.1 -C.sub.6 alkylene group,R.sub.2 represents hydrogen, a C.sub.1 -C.sub.6 alkyl group or a --CONH.sub.2 group,R.sub.3 represents hydrogen, a C.sub.1 -C.sub.6 alkyl group, a benzyl group or a phenyl group optionally substituted by chlorine or methyl groups; or alternativelyR.sub.2 and R.sub.3, taken together, represent a (CH.sub.2).sub.m group, in which m=4 or 5, and finallyn represents 0 or the integer 1 or 2.These derivatives possess antirheumatic properties.