Patents by Inventor Alain Colige

Alain Colige has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHITOSAN BIOMIMETIC SCAFFOLDS AND METHODS FOR PREPARING THE SAME
    Publication number: 20140046236
    Abstract: The present invention relates to a layered chitosan scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one of the fused layers comprises a chitosan nanofiber membrane and the other fused layer comprises a porous chitosan support layer. Moreover, the present invention provides a layered chitosan scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan scaffold. The present invention also provides a process for the preparation of the layered chitosan scaffold.
    Type: Application
    Filed: May 24, 2011
    Publication date: February 13, 2014
    Applicant: UNIVERSITY OF LIEGE
    Inventors: Patrice Filée, Astrid Freichels, Christine Jéröme, Abdelhafid Aquil, Alain Colige, Victor Tchemtchoua Tateu
  • VEGF VARIANTS
    Publication number: 20100287625
    Abstract: This invention relates to a Vascular Endothelial Growth Factor (VEGF) polypeptide, which polypeptide lacks an amino acid sequence encoded by exon 5 of the VEGF gene. This variant of VEGF is capable of eliciting activities associated with VEGF whilst showing resistance to proteolytic degradation. The invention provides uses of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
    Type: Application
    Filed: January 18, 2007
    Publication date: November 11, 2010
    Applicant: UNIVERSITE DE LIEGE
    Inventors: Alain Colige, Pierre Mineur, Charles Lambert
  • Recombinant N-proteinase and methods and uses thereof
    Patent number: 6428998
    Abstract: The present invention relates to novel polynucleotide sequences encoding human N-proteinase, and the polypeptides encoded by such polynucleotide sequences. The present invention further relates to methods for using the polynucleotides encoding human N-proteinase to produce the protein.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: August 6, 2002
    Assignee: University of Liege
    Inventors: Alain Colige, Charles M. Lapiere, Darwin J. Prockop
  • Compositions and methods for detecting altered COL1A1 gene sequences
    Patent number: 6265157
    Abstract: Compositions and methods useful for determining whether a subject has an alteration in a gene encoding a protein chain of Type I or Type IX collagen are described. Novel intronic sequences of five human genes, COL1A1, COL1A2, COL9A1, COL9A2, and COL9A3 are described. Methods of determining the existence in a subject of a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided, wherein such pathological conditions include diseases and disorders which are known to be associated with an altered gene encoding a Type I or Type IX collagen protein chain. Primers, probes, and methods of detecting a genetic predisposition of a subject for a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: July 24, 2001
    Assignees: Allegheny University of the Health Sciences, Thomas Jefferson University, University of Oulu
    Inventors: Darwin J. Prockop, Loretta D. Spotila, Constantinos D. Deltas, Larisa Sereda, Andrea Westerhausen Larson, Michael Pack, Alain Colige, James Early, Jarmo Körkkö, Leena Ala-Kokko, Susanna Annunen, Tero Pihlajamaa, Mirko Vuoristo, Petteri Paassilta
  • Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen
    Patent number: 5861502
    Abstract: The present invention is directed to oligonucleotides that inhibit mutant COL1A1 and/or wild type COL1A1 gene expression. The present invention is further directed to methods of inhibiting mutant and/or wild type collagen gene expression using the disclosed inhibitory oligonucleotides. The oligonucleotides and methods of the present invention are useful for the treatment of mammals having diseases related to inappropriate mutant or wild type COL1A1 gene expression.
    Type: Grant
    Filed: June 30, 1995
    Date of Patent: January 19, 1999
    Assignee: Thomas Jefferson University
    Inventors: Darwin Prockop, Alain Colige, Renato Baserga, Paul Nugent