Patents by Inventor Alain De Mesmaeker

Alain De Mesmaeker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Backbone-modified oligonucleotide analogs and methods for using same
    Publication number: 20020183502
    Abstract: Therapeutic oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. Replacement of phosphorodiester inter-sugar linkages found in wild type oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
    Type: Application
    Filed: May 24, 2002
    Publication date: December 5, 2002
    Inventors: Alain De Mesmaeker, Jacques Lebreton, Adrian Waldner, Phillip Dan Cook
  • Novel herbicides
    Publication number: 20020165096
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: June 21, 2001
    Publication date: November 7, 2002
    Inventors: Juergen Schaetzer, Alain De Mesmaeker, Shy-Fuh Lee
  • Pyrazole derivatives as herbicides
    Publication number: 20020055639
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: June 14, 2001
    Publication date: May 9, 2002
    Inventors: Kurt Nebel, Alain De Mesmaeker, Jurgen Schaetzer
  • Pyridine ketones useful as herbicides
    Publication number: 20020016345
    Abstract: Compounds of formula (I) in which the substituents are as defined in claim 1 are suitable for use as herbicides.
    Type: Application
    Filed: March 12, 2001
    Publication date: February 7, 2002
    Inventors: Andrew Edmunds, Karl Seckinger, Christoph Luthy, Walter Kunz, Alain De Mesmaeker, Jurgen Schaetzer
  • Pyrazole derivatives as herbicides
    Patent number: 6274536
    Abstract: Compounds of the following formula I wherein wherein all variables are as defined in the specification and the pyrazoleN-oxides, agrochemically acceptable salts and stereisomers thereof useful as herbisdes.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: August 14, 2001
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Kurt Nebel, Alain De Mesmaeker, Jürgen Schaetzer
  • Isoxazole derivatives and their use as herbicides
    Patent number: 6255251
    Abstract: Compounds of formula 1 wherein R1 and R2 are independently C1-C8alkyl, are suitable for use as herbicides.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: July 3, 2001
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Alain De Mesmaeker, Jürgen Schaetzer, Walter Kunz
  • Modified oligonucleotides
    Patent number: 6066447
    Abstract: Oligonucleotides of the formula: 5'(U).sub.n -3' in which U is an identical or different radical of a natural or a synthetic nucleoside and n is a number from 2 to 200 comprising at least one structural unit of two consecutive nucleosides wherein one of the nucleotides is substituted in the 2'-position or wherein the nucleotides are substituted differently in their 2'-position and wherein the backbone is modified.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: May 23, 2000
    Assignee: Novartis Corporation
    Inventors: Alain De Mesmaeker, Adrian Waldner, Jacques Lebreton, Marc-Olivier Bevierre, Catherine Lesueur
  • Oligonucleotide analogues
    Patent number: 5670489
    Abstract: A dinucleotide analogue of formula ##STR1## where B.sup.1 and B.sup.2 are each independently a monovalent nucleoside base radical;R.sup.1 is R.sup.1.sub.a or Z;R.sup.1.sub.a, R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, halogen or hydroxy;R.sup.5 is R.sup.5.sub.a or Z;R.sup.6 is hydrogen or R.sup.6.sub.a ;R.sup.7 is hydrogen, alkyl-N,N-dialkylphosphoramidyl or R.sup.7.sub.a, R.sup.8 is R.sup.8.sub.a or Z, or the indicated R.sup.7 O and R.sup.8 together denote an isopropylidenedioxy group;R.sup.5.sub.a and R.sup.8.sub.a are each independently hydrogen, halogen, hydroxy, --OR.sup.10, --OCOR.sup.10 or silyloxy substituted by three C.sub.1 -C.sub.5 hydrocarbyl groups;R.sup.6.sub.a and R.sup.7.sub.a are each independently a C.sub.1 -C.sub.10 aliphatic radical, a C.sub.6 -C.sub.15 aromatic radical, a C.sub.7 -C.sub.30 araliphatic radical, --COR.sup.11, --SO.sub.2 R.sup.11 or silyl substituted by three C.sub.1 -C.sub.15 hydrocarbyl groups;R.sup.9 is hydrogen, a C.sub.1 -C.sub.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 23, 1997
    Assignee: Novartis Corporation
    Inventors: Anthony David Baxter, Eric Keith Baylis, Stephen Paul Collingwood, Roger John Taylor, Alain De Mesmaeker, Chantal Schmit
  • Backbone modified oligonucleotide analogs
    Patent number: 5602240
    Abstract: Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH.sub.2 --CH.sub.2, NR--C(S)--CH.sub.2 --CH.sub.2, CH.sub.2 --NR--C(O)--CH.sub.2, CH.sub.2 --NR--C(S)--CH.sub.2, CH.sub.2 --CH.sub.2 --NR--C(O)--R--CH.sub.2, and CH.sub.2 --C(S)--NR--CH.sub.2. Methods for preparing and using these oligonucleotide analogs are also provided.
    Type: Grant
    Filed: April 25, 1994
    Date of Patent: February 11, 1997
    Assignees: Ciba Geigy AG., Isis Pharmaceuticals, Inc.
    Inventors: Alain De Mesmaeker, Jacques Lebreton, Adrian Waldner, Phillip D. Cook
  • Dinucleoside phosphinates and their pharmaceutical compositions
    Patent number: 5466677
    Abstract: A dinucleotide analogue of formula ##STR1## where B.sup.1 and B.sup.2 are each independently a monovalent nucleoside base radical;R.sup.1 is R.sup.1.sub.a or Z;R.sup.1.sub.a, R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, halogen or hydroxy;R.sup.5 is R.sup.5.sub.a or Z;R.sup.6 is hydrogen or R.sup.6.sub.a ;R.sup.7 is hydrogen, alkyl-N,N-dialkylphosphoramidyl or R.sup.7.sub.a, R.sup.8 is R.sup.8.sub.a or Z, or the indicated R.sup.7 O and R.sup.8 together denote an isopropylidenedioxy group;R.sup.5.sub.a and R.sup.8.sub.a are each independently hydrogen, halogen, hydroxy, --OR.sup.10, --OCOR.sup.10 or silyloxy substituted by three C.sub.1 -C.sub.15 hydrocarbyl groups;R.sup.6.sub.a and R.sup.7.sub.a are each independently a C.sub.1 -C.sub.10 aliphatic radical, a C.sub.6 -C.sub.15 aromatic radical, a C.sub.7 -C.sub.30 araliphatic radical, --COR.sup.11, --SO.sub.2 R.sup.11 or silyl substituted by three C.sub.1 -C.sub.15 hydrocarbyl groups;R.sup.9 is hydrogen, a C.sub.1 -C.sub.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: November 14, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Anthony D. Baxter, Eric K. Baylis, Stephen P. Collingwood, Roger J. Taylor, Alain De Mesmaeker, Chantal Schmit