Patents by Inventor Alain Debrabant

Alain Debrabant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Live attenuated vaccines
    Patent number: 8877213
    Abstract: Targeted disruption of the centrin gene leads to attenuation of growth in the Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulent Leishmania strain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of Leishmania.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: November 4, 2014
    Assignees: The United States of America as Represented by the Secretary of the Department of Health and Human Services, Indian Council of Medical Research
    Inventors: Hira L. Nakhasi, Angamuthu Selvapandiyan, Alain Debrabant, Robert C. Duncan, Poonam Salotra, Gannavaram Sreenivas
  • LIVE ATTENUATED LEISHMANIA VACCINES
    Publication number: 20110081383
    Abstract: Targeted disruption of the centrin gene leads to attenuation of growth in the Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulent Leishmania strain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of Leishmania.
    Type: Application
    Filed: November 15, 2010
    Publication date: April 7, 2011
    Applicants: The Gov. of the United States as Represented by the Secretary, Dept. of Health and Human Services, Institute of Pathology (ICMR)
    Inventors: Hira L. Nakhasi, Angamuthu Selvapandiyan, Alain Debrabant, Robert C. Duncan, Poonam Salotra, Gannavaram Sreenivas
  • Live attenuated vaccines
    Patent number: 7887812
    Abstract: Targeted disruption of the centrin gene leads to attenuation of growth in Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulent Leishmania strain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of Leishmania.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: February 15, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Hira L. Nakhasi, Angamuthu Selvapandiyan, Alain Debrabant, Robert C. Duncan, Poonam Salotra, Gannavaram Sreenivas
  • Live attenuated Leishmania vaccines
    Publication number: 20060240046
    Abstract: Targeted disruption of the centrin gene leads to attenuation of growth in Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulent Leishmania strain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of Leishmania.
    Type: Application
    Filed: February 28, 2006
    Publication date: October 26, 2006
    Inventors: Hira Nakhasi, Angamuthu Selvapandiyan, Alain Debrabant, Robert Duncan, Poonam Salotra, Gannavaram Sreenivas